Výsledky vyhledávání - "glucagon signaling"

Akademický článek

Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes

Autor: Al-Aama JY, Al Mahdi HB, Salama MA, Bakur KH, Alhozali A, Mosli HH, Bahijri SM, Bahieldin A, Willmitzer L, Edris S

Publikováno v: Diabetes, Metabolic Syndrome and Obesity, Vol Volume 12, Pp 2675-2684 (2019)

Jumana Y Al-Aama,1,2 Hadiah B Al Mahdi,1 Mohammed A Salama,1 Khadija H Bakur,1,2 Amani Alhozali,3 Hala H Mosli,3 Suhad M Bahijri,4 Ahmed Bahieldin,5,6 Lothar Willmitzer,7 Sherif Edris1,5,6 1King Abdulaziz University, Princess Al Jawhara Albrahim Cent

Externí odkaz: https://doaj.org/article/79189e4935ce49fea4c9ae4666182588

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Akademický článek

Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7–36) Amide (GLP-1) Secretion by Intestinal L Cell

Autor: Pengzhou Li, Liyong Zhu, Xiangwu Yang, Weizheng Li, Xulong Sun, Bo Yi, Shaihong Zhu

Publikováno v: Cellular Physiology and Biochemistry, Vol 47, Iss 4, Pp 1442-1452 (2018)

Background/Aims: Type II diabetes is a complex, chronic, and progressive disease. Glucagon-like peptide-1 (7–6) amide (GLP-1) is a gut hormone released from the L cells which stimulates insulin secretion, and promotes insulin gene expression and β

Externí odkaz: https://doaj.org/article/c1805ea204d94a55a0abfcad0c5c6dd0

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Purβ promotes hepatic glucose production by increasing Adcy6 transcription

Autor: Xinzhi Li, Yunfeng Jiang, Zheng Chen, Linna Jia

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 31, Iss, Pp 85-97 (2020)

Objective Enhanced glucagon signaling and hepatic glucose production (HGP) can account for hyperglycemia in patients with obesity and type 2 diabetes. However, the detailed molecular mechanisms underlying the enhanced HGP in these patients are not fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa2c903ca6fff7e2ba3595b4eafe721
http://europepmc.org/articles/PMC6920194

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Akademický článek

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Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7–36) Amide (GLP-1) Secretion by Intestinal L Cell

Autor: Zhu Liyong, Bo Yi, Zhu Shaihong, Weizheng Li, Xulong Sun, Xiangwu Yang, Li Pengzhou

Publikováno v: Cellular Physiology and Biochemistry, Vol 47, Iss 4, Pp 1442-1452 (2018)

Background/aims Type II diabetes is a complex, chronic, and progressive disease. Glucagon-like peptide-1 (7-6) amide (GLP-1) is a gut hormone released from the L cells which stimulates insulin secretion, and promotes insulin gene expression and β-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093b9af20852912ce3af1f67ad79c81f
https://doi.org/10.1159/000490836

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Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting

Autor: Almudena Val-Blasco, Marta Cruces-Sande, Daniel Díaz-Rodríguez, Kfir Sharabi, Cristina Murga, Federico Mayor, Rocío Vila-Bedmar, Pere Puigserver, Alba C. Arcones

Publikováno v: FASEB J
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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The liver plays a key role during fasting to maintain energy homeostasis and euglycemia via metabolic processes mainly orchestrated by the insulin/glucagon ratio. We report here that fasting or calorie restriction protocols in C57BL6 mice promote a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3e30fde1be8e1cf547f8526247ec7
http://hdl.handle.net/10261/241169

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Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes

Autor: Jumana Y, Al-Aama, Hadiah B, Al Mahdi, Mohammed A, Salama, Khadija H, Bakur, Amani, Alhozali, Hala H, Mosli, Suhad M, Bahijri, Ahmed, Bahieldin, Lothar, Willmitzer, Sherif, Edris

Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Background Type 2 diabetes, or T2D, is a metabolic disease that results in insulin resistance. In the present study, we hypothesize that metabolomic analysis in blood samples of T2D patients sharing the same ethnic background can recover new metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5779ec04d99f60d4a38f348df33c525
https://pubmed.ncbi.nlm.nih.gov/31908508

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Akademický článek

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Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

Autor: Kohei Kaku, Hideaki Kaneto, Masashi Shimoda, Atsushi Obata, Tomohiko Kimura

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2596, p 2596 (2021)
International Journal of Molecular Sciences

While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine mono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919babc2a28c01c05a37f59eaab887fa
https://doi.org/10.3390/ijms22052596

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