The combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations

Autor: Ryoi Tamura, Satoshi Kuroda, Michiya Sugimori, Yumiko Hayakawa

Publikováno v: Oncotarget

Glioblastoma resists chemotherapy then recurs as a fatal space-occupying lesion. To improve the prognosis, the issues of chemoresistance and tumor size should be addressed. Glioma stem cell (GSC) populations, a heterogeneous power-law coded populatio

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http://europepmc.org/articles/PMC6481323

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Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations.

Autor: Sugimori M; Department of Integrative Neuroscience, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan., Hayakawa Y; Department of Neurosurgery, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan., Koh M; Department of Neurosurgery, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan., Hayashi T; Department of Neurosurgery, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan., Tamura R; Department of Integrative Neuroscience, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan., Kuroda S; Department of Neurosurgery, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.

Publikováno v: Oncotarget [Oncotarget] 2017 Dec 09; Vol. 9 (3), pp. 3043-3059. Date of Electronic Publication: 2017 Dec 09 (Print Publication: 2018).