Zobrazeno 1 - 10
of 565
pro vyhledávání: '"glial cell biology"'
Autor:
Julius V. Emmrich, Jonas J. Neher, Philipp Boehm-Sturm, Matthias Endres, Ulrich Dirnagl, Christoph Harms
Publikováno v:
F1000Research, Vol 6 (2018)
Stroke is a major cause of death and disability worldwide. In addition to neuronal death resulting directly from energy depletion due to lack of blood supply, inflammation and microglial activation following ischemic brain injury has been increasingl
Externí odkaz:
https://doaj.org/article/38f03292e96f4dae945d9e93fb441b8e
Autor:
Takumi Satoh, Stuart Lipton
Publikováno v:
F1000Research, Vol 6 (2017)
Dimethyl fumarate (DMF) is an electrophilic compound previously called BG-12 and marketed under the name Tecfidera®. It was approved in 2013 by the US Food and Drug Administration and the European Medicines Agency for the treatment of relapsing mult
Externí odkaz:
https://doaj.org/article/a467e014f34f4b0b9d04317a663231e5
Autor:
Roshni A Desai, Kenneth J Smith
Publikováno v:
F1000Research, Vol 6 (2017)
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the m
Externí odkaz:
https://doaj.org/article/1a6bd8ad088d4a4bab95becbfc0fa6b9
Autor:
Tomoko Kitago, Rajiv R. Ratan
Publikováno v:
F1000Research, Vol 6 (2017)
Intracerebral hemorrhage (ICH), a form of brain bleeding and minor subtype of stroke, leads to significant mortality and long-term disability. There are currently no validated approaches to promote functional recovery after ICH. Research in stroke re
Externí odkaz:
https://doaj.org/article/6cd164eca3b744388f0255167d468299
Autor:
Julius V. Emmrich, Jonas J. Neher, Philipp Boehm-Sturm, Matthias Endres, Ulrich Dirnagl, Christoph Harms
Publikováno v:
F1000Research, Vol 6 (2017)
Stroke is a major cause of death and disability worldwide. In addition to neuronal death resulting directly from energy depletion due to lack of blood supply, inflammation and microglial activation following ischemic brain injury has been increasingl
Externí odkaz:
https://doaj.org/article/471e413c2216448fbde8637bcb2973be
Publikováno v:
F1000Research, Vol 6 (2017)
A compelling need in the field of neurodegenerative diseases is the development and validation of biomarkers for early identification and differential diagnosis. The availability of positron emission tomography (PET) neuroimaging tools for the assess
Externí odkaz:
https://doaj.org/article/e600b6f7426d415aa998debc0eb117ab
Publikováno v:
F1000Research, Vol 6 (2017)
Hepatic encephalopathy describes the array of neurological alterations that occur during acute liver failure or chronic liver injury. While key players in the pathogenesis of hepatic encephalopathy, such as increases in brain ammonia, alterations in
Externí odkaz:
https://doaj.org/article/1dce84238be145feb036a531f9579246
Autor:
Alana M. Horowitz, Saul A. Villeda
Publikováno v:
F1000Research, Vol 6 (2017)
Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative diseas
Externí odkaz:
https://doaj.org/article/534eecfeb7c74371b51c5cad60d9db21
Autor:
Tony J. C. Harris
Publikováno v:
F1000Research, Vol 6 (2017)
The scaffold protein Par-3 (Drosophila Bazooka) is a central organizer of cell polarity across animals. This review focuses on how the clustering of Par-3 contributes to cell polarity. It begins with the Par-3 homo-oligomerization mechanism and its r
Externí odkaz:
https://doaj.org/article/9207b6e446a74a42a66badc7b70969ec
Publikováno v:
F1000Research, Vol 6 (2017)
Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised patholog
Externí odkaz:
https://doaj.org/article/dafe9853e11d46fcb466b5601cc69ab4