Zobrazeno 1 - 10
of 321
pro vyhledávání: '"germinal center B cell"'
Publikováno v:
Advances in Rheumatology, Vol 63, Iss 1, Pp 1-9 (2023)
Abstract Introduction/objectives Systemic lupus erythematosus (SLE) is a classic prototype of the multisystem autoimmune disease and follows a relapsing and remitting course. Triptolide is a diterpene triepoxide extracted from Chinese medicine Tripte
Externí odkaz:
https://doaj.org/article/f6c83f9340ce4b2c8b5fd1fc7ad638e6
Autor:
Shu Horiuchi, Takuya Koike, Hirofumi Takebuchi, Katsuaki Hoshino, Izumi Sasaki, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Daisuke Kitamura
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Generation of memory B cells is one of the key features of adaptive immunity as they respond rapidly to re-exposure to the antigen and generate functional antibodies. Although the functions of memory B cells are becoming clearer, the regulation of me
Externí odkaz:
https://doaj.org/article/b6035da134f149289bcc8ae857600063
Autor:
Sofia Bin, Chiara Cantarelli, Julian K. Horwitz, Micaela Gentile, Manuel Alfredo Podestà, Gaetano La Manna, Peter S. Heeger, Paolo Cravedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAdministration of recombinant erythropoietin (EPO), a kidney-produced hormone with erythropoietic functions, has been shown to have multiple immunoregulatory effects in mice and humans, but whether physiological levels of EPO regulate immun
Externí odkaz:
https://doaj.org/article/c8f23f4f142d45d783bbc302d4349977
Akademický článek
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Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Gammaherpesviruses establish lifelong infections in most vertebrate species, including humans and rodents, and are associated with cancers, including B cell lymphomas. While type I and II interferon (IFN) systems of the host are critical for
Externí odkaz:
https://doaj.org/article/3e446d44ee6d433188a7516382f60df1
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background The pathogenesis of germinal center B-cell type diffuse large B-cell lymphoma (GCB-DLBCL) is not fully elucidated. This study aims to explore the regulation of super enhancers (SEs) on GCB-DLBCL by identifying specific SE-target g
Externí odkaz:
https://doaj.org/article/e7c4db9fa1c843f28c3a0931523b64dc
Publikováno v:
Avicenna Journal of Medicine, Vol 10, Iss 04, Pp 241-248 (2020)
Background: CD10, BCL6, and MUM1 are commonly used immunohistochemical stains for classifying diffuse large B-cell lymphoma (DLBCL), which is useful in predicting outcome. Conflicting reports of the prognostic value of other markers such as BCL2, CD2
Externí odkaz:
https://doaj.org/article/21e69264957a45539c6717acbbe9b2d7
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Both acute and chronic antibody-mediated allograft rejection (AMR), which are directly mediated by B cells, remain difficult to treat. Long-lived plasma cells (LLPCs) in bone marrow (BM) play a crucial role in the production of the antibodies that in
Externí odkaz:
https://doaj.org/article/c5fa4e1a34a54619aec0b2780aaa5909
Autor:
Nathalie Faumont, Oussama Taoui, Davi Collares, Jean-Philippe Jais, Karen Leroy, Léa Prévaud, Fabrice Jardin, Thierry J. Molina, Christiane Copie-Bergman, Barbara Petit, Marie-Pierre Gourin, Dominique Bordessoule, Danielle Troutaud, Véronique Baud, Jean Feuillard
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activ
Externí odkaz:
https://doaj.org/article/cc5e9e2c17bf4d2bb3dc4179c7dae410