Výsledky vyhledávání - "george R. Dakwar"

Akademický článek

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Autor: Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H. pylori

Externí odkaz: https://doaj.org/article/c2573389785b4b008350aa1ac492161f

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PEGylated and functionalized aliphatic polycarbonate polyplex nanoparticles for intravenous administration of HDAC5 siRNA in cancer therapy

Autor: Denis Mottet, Alexandra Baroni, Elodie Hendrick, Géraldine Piel, Julie Laloy, Georges Feller, George R. Dakwar, François Orange, Olivier Peulen, Antoine Frère, Philippe Dubois, Brigitte Evrard, Laetitia Mespouille, Stefaan C. De Smedt, Jérôme Diricq, Katrien Remaut, Kevin Braeckmans, Jean-Michel Dogné, Anne Sophie Delvigne

Publikováno v: ACS APPLIED MATERIALS & INTERFACES

Guanidine and morpholine functionalized aliphatic polycarbonate polymers are able to deliver efficiently histone deacetylase 5 (HDAC5) siRNA into the cytoplasm of cancer cells in vitro leading to a decrease of cell proliferation were previously devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbd8bad7d33e23fd026ac641ea49f11
https://researchportal.unamur.be/en/publications/dfc94075-f476-4765-9362-67079ea1cf01

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In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions

Autor: Wim E. Hennink, Twan Lammers, Yinan Chen, George R. Dakwar, Josbert M. Metselaar, Kevin Braeckmans

Publikováno v: Macromolecular Bioscience, 18(1). Wiley-VCH Verlag
MACROMOLECULAR BIOSCIENCE
Macromolecular bioscience, 18(1):1700127. Wiley-VCH Verlag

The in vivo stability and biodegradability of nanocarriers crucially determine therapeutic efficacy as well as safety when used for drug delivery. This study aims to evaluate optimized in vitro techniques predictive for in vivo nanocarrier behavior.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541c8259b2877abff3d793cb8aafe7da
https://dspace.library.uu.nl/handle/1874/374654

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Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

Autor: Bo Lou, Wim E. Hennink, Cornelus F. van Nostrum, Kevin Braeckmans, Wilhelm Jahnen-Dechent, Luís Novo, Twan Lammers, Katrien Remaut, Susanne K. Golombek, Enrico Mastrobattista, George R. Dakwar, Larissa Y. Rizzo, Fabian Kiessling

Publikováno v: JOURNAL OF CONTROLLED RELEASE
Journal of controlled release, 195, 162-175. Elsevier

Many polycation-based gene delivery vectors show high transfection in vitro, but their cationic nature generally leads to significant toxicity and poor in vivo performance which significantly hampers their clinical applicability. Unlike conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8044a8030eaa4785532b84847136bb
https://doi.org/10.1016/j.jconrel.2014.08.028

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Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

Autor: Nuno F. Azevedo, Ceu Figueiredo, George R. Dakwar, Koen Raemdonck, Rita S. Santos, Toon Brans, Kevin Braeckmans, Stefaan C. De Smedt, Elisa Zagato

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
BIOMATERIALS
Biomaterials

The rising antimicrobial resistance contributes to 25000 annual deaths in Europe. This threat to the public health can only be tackled if novel antimicrobials are developed, combined with a more precise use of the currently available antibiotics thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fe9bd22fd1a51b2ebafb0f350d560f
https://hdl.handle.net/10216/116013

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Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

Autor: Molood Shariati, Katrien Remaut, George R. Dakwar, Wim Ceelen, Stefaan C. De Smedt, Wouter Willaert

Publikováno v: Advanced Drug Delivery Reviews
ADVANCED DRUG DELIVERY REVIEWS

Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal carcinomatosis (PC). Over the past decade, a lot of effort has been put both in the academia and clinic in developing IP therapeutic approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7988c1097405c0ce1f101fc0e0c0a9

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