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Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells

Autor: Hongyu Shi, Marc J. Williams, Gryte Satas, Adam C. Weiner, Andrew McPherson, Sohrab P. Shah

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal instability and result in heterogeneous cancer cell populations with distinct phenotypes. However, the extent to which subclonal copy number alteration

Externí odkaz: https://doaj.org/article/016f0a9687414f4ba21344c902418beb

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

Autor: Kyratzi P; School of Veterinary Medicine and Science, University of Nottingham, College Road, Sutton Bonington, LE12 5RD, UK.; École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, 34 rue Crozatier, 75012 Paris, France., Matika O; Div. Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK., Brassington AH; Agriculture and Horticulture Development Board, Middlemarch Business Park Siskin Parkway, East Coventry CV3 4PE, UK., Clare CE; School of Biosciences, University of Nottingham, College Road, Sutton Bonington, LE12 5RD, UK., Xu J; Shanghai Leadingtac Pharmaceutical Co., Ltd, 781 Cailun Road, China (Shanghai) Pilot Free Trade Zone, Pudong, Shanghai 201203, China., Barrett DA; Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Emes RD; Nottingham Trent University, 50 Shakespeare Street, Nottingham NG1 4FQ, UK., Archibald AL; Div. Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK., Paldi A; École Pratique des Hautes Études, PSL Research University, St-Antoine Research Center, Inserm U938, 34 rue Crozatier, 75012 Paris, France., Sinclair KD; Agriculture and Horticulture Development Board, Middlemarch Business Park Siskin Parkway, East Coventry CV3 4PE, UK., Wattis J; Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Rauch C; School of Veterinary Medicine and Science, University of Nottingham, College Road, Sutton Bonington, LE12 5RD, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 13. Date of Electronic Publication: 2024 Aug 13.

Genotype-Phenotype Mapping for Applied Evolutionary Multi-Objective and Multi-Physics Topology Optimization

Autor: Felix Schleifer, Kevin Deese

Publikováno v: Applied Mechanics, Vol 3, Iss 4, Pp 1399-1416 (2022)

We present a multi-objective topology optimization method based on the Non-Sorting Genetic Algorithm II (NSGA-II). The presented approach is a tool for early-stage engineering applications capable of providing insights into the complex relationship b

Externí odkaz: https://doaj.org/article/5aeae719204b469988c5636547dc78d9

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Autor: Kawasaki, Kenta, Toshimitsu, Kohta, Matano, Mami, Fujita, Masashi, Fujii, Masayuki, Togasaki, Kazuhiro, Ebisudani, Toshiki, Shimokawa, Mariko, Takano, Ai, Takahashi, Sirirat, Ohta, Yuki, Nanki, Kosaku, Igarashi, Ryo, Ishimaru, Kazuhiro, Ishida, Hiroki, Sukawa, Yasutaka, Sugimoto, Shinya, Saito, Yoshimasa, Maejima, Kazuhiro, Sasagawa, Shota, Lee, Hwajin, Kim, Hong-Gee, Ha, Kyungsik, Hamamoto, Junko, Fukunaga, Koichi, Maekawa, Aya, Tanabe, Minoru, Ishihara, Soichiro, Hamamoto, Yasuo, Yasuda, Hiroyuki, Sekine, Shigeki, Kudo, Atsushi, Kitagawa, Yuko, Kanai, Takanori, Nakagawa, Hidewaki, Sato, Toshiro

Publikováno v: In Cell 25 November 2020 183(5):1420-1435