Zobrazeno 1 - 10
of 770
pro vyhledávání: '"genomic profile"'
Autor:
Elham Aida Farshadi, Wenya Wang, Farzana Mohammad, Elise van der Oost, Michail Doukas, Casper H. J. van Eijck, Harmen J. G. van de Werken, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhan
Externí odkaz:
https://doaj.org/article/77ac9a8ef4ef4a1b84739b3ddce172bb
Autor:
Laura Andersen, Ditte S. Christensen, Asbjørn Kjær, Michael Knudsen, Andreas K. Andersen, Maria B. Laursen, Johanne Ahrenfeldt, Britt E. Laursen, Nicolai J. Birkbak
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2393-2406 (2024)
Cancer of unknown primary (CUP) tumors are biologically very heterogeneous, which complicates stratification of patients for treatment. Consequently, these patients face limited treatment options and a poor prognosis. With this study, we aim to expan
Externí odkaz:
https://doaj.org/article/7243d7b50f8045679e26cd6e21614f9f
Autor:
Stefania Tommasi, Leonarda Maurmo, Alessandro Rizzo, Claudia Carella, Girolamo Ranieri, Simona De Summa, Francesco Mannavola, Vincenzo Emanuele Chiurì, Michele Guida, Claudia Nisi, Michele Montrone, Francesco Giotta, Margherita Patruno, Rosanna Lacalamita, Brunella Pilato, Francesco Alfredo Zito, Livia Fucci, Claudio Antonio Coppola, Paolo Ditonno, Patrizia Nardulli, Davide Quaresmini, Sabino Strippoli
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/1c58613e298c493da74ca2ff9aa2a01d
Autor:
Stefania Tommasi, Leonarda Maurmo, Alessandro Rizzo, Claudia Carella, Girolamo Ranieri, Simona De Summa, Francesco Mannavola, Vincenzo Emanuele Chiurì, Michele Guida, Claudia Nisi, Michele Montrone, Francesco Giotta, Margherita Patruno, Rosanna Lacalamita, Brunella Pilato, Francesco Alfredo Zito, Livia Fucci, Claudio Antonio Coppola, Paolo Ditonno, Patrizia Nardulli, Davide Quaresmini, Sabino Strippoli
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe management of cancer patients follows a Diagnostic Therapeutic and Care Pathway (PDTA) approach, aimed at achieving the optimal balance between care and quality of life. To support this process, precision medicine and innovative techn
Externí odkaz:
https://doaj.org/article/2824a801b9c443929b2a0c033b56eab4
Publikováno v:
Breast, Vol 76, Iss , Pp 103752- (2024)
Introduction: The financial impact of breast cancer has been discussed due to its high incidence and the increased costs of systemic therapy and is even more relevant in countries with low and medium socioeconomic development. Objective: To evaluate
Externí odkaz:
https://doaj.org/article/7db95704765d48258e378cc16211701c
Autor:
Vlad Bogdan Varzaru, Tania Vlad, Roxana Popescu, Cristian Sebastian Vlad, Aurica Elisabeta Moatar, Ionut Marcel Cobec
Publikováno v:
Diagnostics, Vol 14, Iss 17, p 1875 (2024)
Worldwide, breast cancer (BC) is one of the most common cancers in women and is responsible for the highest number of cancer-related deaths among women, with a special clinical behavior and therapy response. Triple-negative breast cancer (TNBC) is se
Externí odkaz:
https://doaj.org/article/6cea1c44b17d4247983b4e053345341d
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Backgrounds Endometrial carcinoma (EC) is one of the most commonly diagnosed gynecologic malignancy in China. However, the genetic profile of Chinese EC patients has not been well established yet. Methods In current study, 158 Chinese EC pat
Externí odkaz:
https://doaj.org/article/7ac149d7b3e245a1b0523010a5284dca
Autor:
Namsoo Kim, Yu Jeong Choi, Seung-Tae Lee, Jong Rak Choi, Chuhl Joo Lyu, Saeam Shin, June-Won Cheong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAplastic anemia (AA), characterized by hematopoietic stem cell deficiency, can evolve into different hematologic malignancies. Our understanding of the genetic basis and mechanisms of this progression remains limited.MethodsWe retrospective
Externí odkaz:
https://doaj.org/article/3f637380a45a42bf99f382d6d6143550
Autor:
Yeon Hee Park, Seock-Ah Im, Kyunghee Park, Ji Wen, Kyung-Hun Lee, Yoon-La Choi, Won-Chul Lee, Ahrum Min, Vinicius Bonato, Seri Park, Sripad Ram, Dae-Won Lee, Ji-Yeon Kim, Su Kyeong Lee, Won-Woo Lee, Jisook Lee, Miso Kim, Hyun Seon Kim, Scott L. Weinrich, Han Suk Ryu, Tae Yong Kim, Stephen Dann, Yu-Jin Kim, Diane R. Fernandez, Jiwon Koh, Shuoguo Wang, Song Yi Park, Shibing Deng, Eric Powell, Rupesh Kanchi Ravi, Jadwiga Bienkowska, Paul A. Rejto, Woong-Yang Park, Zhengyan Kan
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine therapy (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast cancer (HR+/HER2− MBC
Externí odkaz:
https://doaj.org/article/e43bea5e36154033b3975c0ba6d40d38
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