Molecular diagnosis of bovine tuberculosis on postmortem carcasses during routine meat inspection in Benin: GeneXpert® testing to improve diagnostic scheme

Autor: Cyrille K. Boko, Ange-Régis Zoclanclounon, Camus M. Adoligbe, Hebert Dedehouanou, Marguéritte M'Po, Samuel Mantip, Souaïbou Farougou

Publikováno v: Veterinary World, Vol 15, Iss 10, Pp 2506-2510 (2022)

Background and Aim: Bovine tuberculosis (TB) is a zoonotic disease of major public health importance, particularly in African countries, where control measures are limited or largely not applied. This study aimed to determine the accuracy of the curr

Externí odkaz: https://doaj.org/article/6130a06443424160beeaac57e66696da

Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway

Autor: Xiaodong Xu, Yan Yu, Ke Zong, Pengwei Lv, Yuantin Gu

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)

Abstract Background The survival of pancreatic cancer patients remains poor. However, the underlying molecular mechanism and new therapeutic target of pancreatic cancer are still needed to be found. Many studies have shown that the IGF2 mRNA-binding

Externí odkaz: https://doaj.org/article/acbf0bbe4e9f447fb633e80f803f1a67

A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: From genomic characterization to high‐throughput field detection

Autor: Jean-Marc Bonneville, Frederic Laporte, Ian W. Sutherland, Benedicte Fustec, Jeffrey C. Hertz, Tristan Cumer, Sébastien Marcombe, Julien Renaud, Thierry Gaude, Jean-Philippe David, Sébastien Boyer, Camille Noûs, Victor Arnaud, Chloé Haberkorn, Julien Cattel

Publikováno v: Evolutionary Applications, Vol 14, Iss 4, Pp 1009-1022 (2021)
Evolutionary Applications
Evolutionary Applications, Blackwell, 2021, 14 (4), pp.1009-1022. ⟨10.1111/eva.13177⟩
Evolutionary Applications, 2021, 14 (4), pp.1009-1022. ⟨10.1111/eva.13177⟩

By altering gene expression and creating paralogs, genomic amplifications represent a key component of short-term adaptive processes. In insects, the use of insecticides can select gene amplifications causing an increased expression of detoxification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270925fc9a895eb33458a2d82072739e
https://doaj.org/article/334ae7e857a048d7a90a798545727698

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The Antibiotic Dosage of Fastest Resistance Evolution: Gene Amplifications Underpinning the Inverted-U

Autor: Carlos Reding, Robert E. Beardmore, Gunther Jansen, Phillip Rosenstiel, Hinrich Schulenburg, Pablo Catalán, Tobias Bergmiller, Ivana Gudelj, Emily Wood

Publikováno v: Molecular Biology and Evolution
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
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To determine the dosage at which antibiotic resistance evolution is most rapid, we treated Escherichia coli in vitro, deploying the antibiotic erythromycin at dosages ranging from zero to high. Adaptation was fastest just below erythromycin’s minim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6038ee54845978dedda321692c351d
https://pubmed.ncbi.nlm.nih.gov/33693929