Zobrazeno 1 - 10
of 754
pro vyhledávání: '"genomic aberrations"'
Autor:
Jia Huang, Dong Wu, Jia-Huan He, Jing-Yuan Wang, Xi Li, Zheng-Yuan Wang, Yue Wang, Hong-Yan Liu
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectivesRegarding increased nuchal translucency (NT), the cutoff values used are heterogeneous in clinical practice, this study aims to assess the efficacy of prenatal detection for chromosomal abnormalities and pregnancy outcomes in fetuses with v
Externí odkaz:
https://doaj.org/article/4be3772da8414e71a189c0a2e2731df6
Autor:
Fatemah Rezayee, Jesper Eisfeldt, Aron Skaftason, Ingegerd Öfverholm, Shumaila Sayyab, Ann Christine Syvänen, Khurram Maqbool, Henrik Lilljebjörn, Bertil Johansson, Linda Olsson-Arvidsson, Christina Orsmark Pietras, Anna Staffas, Lars Palmqvist, Thoas Fioretos, Lucia Cavelier, Linda Fogelstrand, Jessica Nordlund, Valtteri Wirta, Richard Rosenquist, Gisela Barbany
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic methods.Metho
Externí odkaz:
https://doaj.org/article/40bdae45ba894ef6ae31e5164ee7f34f
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Purpose To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population in real-world. Methods We analyzed PIK3CA mutation status in sequencing data of cell-free DNA from plasma and genomic DNA from mat
Externí odkaz:
https://doaj.org/article/1dfa552c1b99410aadccb3eda1d6f3d8
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Genetic diagnostics of hematological malignancies has evolved dramatically over the years, from chromosomal banding analysis to next-generation sequencing, with a corresponding increased capacity to detect clinically relevant prognostic and predictiv
Externí odkaz:
https://doaj.org/article/0e7be72c8b4347f98a4f40b698e54f36
Autor:
Elisavet Vlachonikola, Nikolaos Pechlivanis, Georgios Karakatsoulis, Electra Sofou, Glykeria Gkoliou, Sabine Jeromin, Niki Stavroyianni, Pamela Ranghetti, Lydia Scarfo, Cecilia Österholm, Larry Mansouri, Sofia Notopoulou, Alexandra Siorenta, Achilles Anagnostopoulos, Paolo Ghia, Claudia Haferlach, Richard Rosenquist, Fotis Psomopoulos, Anastasia Kouvatsi, Panagiotis Baliakas, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMicroenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL pa
Externí odkaz:
https://doaj.org/article/f6260cb340aa4912a28e943471aebbb0
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract It is recognized that the tumor microenvironment (TME) plays a critical role in the biology of cancer. To better understand the role of immune cell components in CNS tumors, we applied a deconvolution approach to bulk DNA methylation array d
Externí odkaz:
https://doaj.org/article/86582e409d6644af891545d54645e268
Gender differences in molecular‐guided therapy recommendations for metastatic malignant mesothelioma
Autor:
Hossein Taghizadeh, Sabine Zöchbauer‐Müller, Robert M. Mader, Leonhard Müllauer, Thomas Klikovits, Thomas Bachleitner‐Hofmann, Mir A. Hoda, Gerald W. Prager
Publikováno v:
Thoracic Cancer, Vol 11, Iss 7, Pp 1979-1988 (2020)
Abstract Background Malignant mesothelioma is an aggressive cancer and has a poor prognosis. Here, we analyzed the feasibility, molecular and gender aspects of targeted therapy recommendations for malignant mesothelioma based on the individual molecu
Externí odkaz:
https://doaj.org/article/a04bb54214904b2682b9ee2765ed5071
Autor:
Jianghua Wu, Wei Sun, Haiyue Wang, Xiaozheng Huang, Xinyu Wang, Weiyang Jiang, Ling Jia, Ping Wang, Qin Feng, Dongmei Lin
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 4, Pp 811-821 (2019)
ObjectiveTo investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma (LADC) patients.MethodsWe reviewed 428 consecutive, surgically resected cases of LADC from October 2015 to
Externí odkaz:
https://doaj.org/article/0be04177778d4bdd9a571c82aaa26d45
Akademický článek
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Autor:
Kosuke Mochida, Shingo Nakahata, Yutaka Suzuki, Kentaro Inoue, Sayaka Moriguchi, Atsushi Yamashita, Masahiro Amano, Kazuhiro Morishita
Publikováno v:
Journal of Dermatological Science. 109:80-88
BackgroundPatients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d48d8c7d2ae1832e2fe768f4adc30b9
https://doi.org/10.1016/j.jdermsci.2023.02.001
https://doi.org/10.1016/j.jdermsci.2023.02.001