Zobrazeno 1 - 10
of 69
pro vyhledávání: '"genome design"'
Publikováno v:
iMeta, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Over the past few decades, there has been a significant interest in the study of essential genes, which are crucial for the survival of an organism under specific environmental conditions and thus have practical applications in the fields of
Externí odkaz:
https://doaj.org/article/51c62d967c78433282fecd6ca1081081
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jean‐Christophe Lachance, Dominick Matteau, Joëlle Brodeur, Colton J Lloyd, Nathan Mih, Zachary A King, Thomas F Knight, Adam M Feist, Jonathan M Monk, Bernhard O Palsson, Pierre‐Étienne Jacques, Sébastien Rodrigue
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 7, Pp n/a-n/a (2021)
Abstract Mesoplasma florum, a fast‐growing near‐minimal organism, is a compelling model to explore rational genome designs. Using sequence and structural homology, the set of metabolic functions its genome encodes was identified, allowing the rec
Externí odkaz:
https://doaj.org/article/ffd50eb1a2234bef84adfb826296e9f3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Oliver Purcell, Joshua Rees, Oliver Chalkley, Sophie Landon, Claire S. Grierson, Lucia Marucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
In the future, entire genomes tailored to specific functions and environments could be designed using computational tools. However, computational tools for genome design are currently scarce. Here we present algorithms that enable the use of design-s
Autor:
Sébastien Rodrigue, Bernhard O. Palsson, Dominick Matteau, Jean-Christophe Lachance, Joëlle Brodeur, Adam M. Feist, Zachary A. King, Thomas F. Knight, Colton J. Lloyd, Nathan Mih, Jonathan M. Monk, Pierre-Étienne Jacques
Publikováno v:
Lachance, JC, Matteau, D, Brodeur, J, Lloyd, C J, Mih, N, King, Z A, Knight, T F, Feist, A M, Monk, J M, Palsson, B O, Jacques, PÉ & Rodrigue, S 2021, ' Genome-scale metabolic modeling reveals key features of a minimal gene set ', Molecular Systems Biology, vol. 17, no. 7, e10099 . https://doi.org/10.15252/msb.202010099
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 7, Pp n/a-n/a (2021)
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 7, Pp n/a-n/a (2021)
Mesoplasma florum, a fast‐growing near‐minimal organism, is a compelling model to explore rational genome designs. Using sequence and structural homology, the set of metabolic functions its genome encodes was identified, allowing the reconstructi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efe59c4f39bd5f147ed48a859da769d
https://orbit.dtu.dk/en/publications/6c5fb099-d5ce-4372-8b47-e669ebfea949
https://orbit.dtu.dk/en/publications/6c5fb099-d5ce-4372-8b47-e669ebfea949
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Lachance, Jean-Christophe, Matteau, Dominick, Brodeur, Joëlle, Lloyd, Colton J, Mih, Nathan, King, Zachary A, Knight, Thomas F, Feist, Adam M, Monk, Jonathan M, Palsson, Bernhard O, Jacques, Pierre-Étienne, Rodrigue, Sébastien
Publikováno v:
Molecular systems biology, vol 17, iss 7
Mesoplasma florum, a fast-growing near-minimal organism, is a compelling model to explore rational genome designs. Using sequence and structural homology, the set of metabolic functions its genome encodes was identified, allowing the reconstruction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::98c2872c9c90597741862f4a041007c3
https://escholarship.org/uc/item/24g8t7mg
https://escholarship.org/uc/item/24g8t7mg
Publikováno v:
Landon, S, Rees, J, Marucci, L & Grierson, C 2019, ' Genome-driven cell engineering review : In vivo and in silico metabolic and genome engineering ', Essays in Biochemistry, vol. 63, no. 2, pp. 267-284 . https://doi.org/10.1042/EBC20180045
Producing ‘designer cells’ with specific functions is potentially feasible in the near future. Recent developments, including whole-cell models, genome design algorithms and gene editing tools, have advanced the possibility of combining biologica
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 70-81 (2019)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Plasmids are genetic parasites of microorganisms. The genomes of naturally occurring plasmids are expected to be polished via natural selection to achieve long-term persistence in the microbial cell population. However, plasmid genomes are extremely