Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease

Autor: Mehmet Ilyas Cosacak, Prabesh Bhattarai, Philip L. De Jager, Vilas Menon, Giuseppe Tosto, Caghan Kizil

Publikováno v: Cells; Volume 11; Issue 11; Pages: 1807
Cells 11(11), 1807 (2022). doi:10.3390/cells11111807 special issue: "Neurogenesis and Regeneration in Teleost Central Nervous System"

Neurogenesis is significantly reduced in Alzheimer’s disease (AD) and is a potential therapeutic target. Contrary to humans, a zebrafish can regenerate its diseased brain, and thus is ideal for studying neurogenesis. To compare the AD-related molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3063827335ab9ac17bfb55300d804eb

KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer’s Disease

Autor: Stanislava Popova, Prabesh Bhattarai, Richard Mayeux, Caghan Kizil, Sanjeev Sariya, Yixin Zhang, Mehmet Ilyas Cosacak, Giuseppe Tosto, Tohid Siddiqui

Publikováno v: Cells
Volume 10
Issue 10
Cells 10(10), 2748 (2021). doi:10.3390/cells10102748 special issue: "Neurogenesis and Regeneration in Teleost Central Nervous System"
Cells, Vol 10, Iss 2748, p 2748 (2021)

Neurogenesis decreases in Alzheimer’s disease (AD) patients, suggesting that restoring the normal neurogenic response could be a disease modifying intervention. To study the mechanisms of pathology-induced neuro-regeneration in vertebrate brains, z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b801af017c4f9f4a0923a0d4a9fc3668

Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain

Autor: Caghan Kizil, Sudipto Roy, Nachiket D. Kashikar, David Liebl, Kazu Kikuchi, Dagmar Wachten, Emre Yaksi, Mehmet Ilyas Cosacak, Benedikt S. Nilges, Christa Ringers, Astha Gupta, Francisca Acuña-Hinrichsen, Nathalie Jurisch-Yaksi, Ahsen Konac, Dheeraj Rayamajhi, Charlton Kang An Lim, Subhra Prakash Hui, Percival P. D’Gama, Jan N. Hansen, Yan Ling Chong, Chee Peng Ng, Tao Qiu, Emilie W. Olstad

Publikováno v: Cell reports 37(1), 109775 (2021). doi:10.1016/j.celrep.2021.109775
Cell Reports, Vol 37, Iss 1, Pp 109775-(2021)
Cell reports
Cell Reports

Summary Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1fd9d411a42424d116a6de37aaa405
https://pub.dzne.de/record/162905

Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients

Autor: Thomas Besnard, Kristian Tveten, Hilary F Kitson, Jennifer A. Lee, Brieana Fregeau, Rachel Schot, Khadija Wilson, Katrin Õunap, Juliane Winkelmann, Anna Lehman, Nicola Longo, Servi J. C. Stevens, Megan T. Cho, Christina G.S. Palmer, Causes Study, Giovanni Battista Ferrero, Joy Dean, Lone W. Laulund, Grazia M.S. Mancini, Matias Wagner, Martin G. Martin, Sabine Lüttgen, Elizabeth J. Bhoj, Amanda J. Yoon, Thomas Klopstock, Janet S. Sinsheimer, Eric Vilain, Sébastien Küry, Francesca Clementina Radio, Jiddeke M. van de Kamp, Cameron Mrokse, Hakon Hakonarson, Samuel G. Cox, Jeanette C. Papp, Margot I. Van Allen, Raymond J. Louie, Constance T. R. M. Stumpel, Evan F. Joiner, Juanita Neira, Arve Vøllo, Amy Pizzino, Kelly Radtke, Celeste Simon, Michelle L. Thompson, Allison Zheng, Omar Sherbini, Marcia C. Willing, Tim M. Strom, Benjamin Garcia, Sara S. Cathey, Theresa A. Grebe, Dong Li, Marjan M. Weiss, Marco Tartaglia, Laura M Bryant, Sandra Mercier, Katherine L. Helbig, Martin Jakob Larsen, Ddd Study, Alexandrea Wadley, Alexander P.A. Stegmann, Sabina Barresi, A. Micheil Innes, Elaine H. Zackai, Gregory Costain, Davor Lessel, Molly Snyder, Heather P. Crawford, Richard Redon, Pearl Lee, Melissa Byler, Holly Dubbs, J. Gage Crump, K. E. Stuurman, Boris Keren, Stéphane Bézieau, Stan F. Nelson, Kristin G. Monaghan, Michael J. Lyons, Jeffrey W. Innis, Anna C.E. Hurst, Elizabeth A. Sellars, Samantha A. Schrier Vergano, Saadet Mercimek-Andrews, Monica H. Wojcik, Alison Ross, Heiko Reutter, Zuo-Fei Yuan, Dylan M. Marchione, Renee Bend, Diana Carli, Zöe Powis, Neil H. Parker, Jennifer Muncy Thomas, Luis A. Umaña, Adeline Vanderver, Julia Hoefele, Linda Manwaring, Christina Fagerberg, Elly Brokamp, M. Stephen Meyn, Pilvi Ilves, Xavier de la Cruz, Nina Powell-Hamilton, Caroline Nava, Garrett Gotway, Karit Reinson, Kristin D. Kernohan, Jennifer Norman, Alexandra Afenjar, Benjamin Cogné, Delphine Héron, Roman Günthner, Alfredo Brusco, John Dean, Kevin A. Janssen, Robert Roger Lebel, Divya Nair, Jijun Wan, Julian A. Martinez-Agosto, Elliott H. Sherr, Kyle Retterer, Claudia B. Catarino, Michael E. March, Natalia Padilla, Elise Brimble, Sylvie Odent, Jane L. Schuette, David Chitayat, Klaas J. Wierenga, Kirsty McWalter, Trine Prescott, Jonas Denecke, Wendy K. Chung

Publikováno v: Science Advances, 6(49):eabc9207. American Association for the Advancement of Science
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
DDD Study, Care4Rare Canada Consortium, CAUSES Study & Undiagnosed Diseases Network 2020, ' Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients ', Science Advances, vol. 6, no. 49, eabc9207 . https://doi.org/10.1126/sciadv.abc9207
Science advances, 6(49):9207. American Association for the Advancement of Science
Science advances, 6(49):eabc9207. American Association for the Advancement of Science
Bryant, L, Li, D, Cox, S G, Marchione, D, Joiner, E F, Wilson, K, Fagerberg, C, Laulund, L W, Larsen, M J & DDD Study 2020, ' Histone H3.3 beyond cancer : Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients ', Science Advances, vol. 6, no. 49, eabc9207 . https://doi.org/10.1126/sciadv.abc9207
Science advances 6(49), eabc9207 (2020). doi:10.1126/sciadv.abc9207
Sci. Adv. 6:106267 (2020)

Germ line mutations in H3F3A and H3F3B cause a previously unidentified neurodevelopmental syndrome. Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c29be398973d47026c90ba29e60cd
https://doi.org/10.1126/sciadv.abc9207

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency

Autor: Michael Orth, Bjarne Udd, Markus Otto, Peter M. Andersen, S.K. Ponna, Kerstin Kojer, Kathrin Muller, Jörg Reinders, Christoph Paone, Peter Lichtner, Petri Kursula, Andreas Hermann, Karin M Danzer, Steffen Just, Anika M. Helferich, Paul Walther, Manu Jokela, Jochen H. Weishaupt, Mari Auranen, Sarah J Brockmann, Axel Freischmidt, Albert C. Ludolph, Patrick Oeckl

Publikováno v: Human molecular genetics 27(4), 706-715 (2018). doi:10.1093/hmg/ddx436
Hum. Mol. Genet. 27, 706-715 (2018)

Mutations in the mitochondrially located protein CHCHD10 cause motoneuron disease by an unknown mechanism. In this study, we investigate the mutations p. R15L and p. G66V in comparison to wild-type CHCHD10 and the non-pathogenic variant p. P34S in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab8a25348673d8f4074e4f547b293a9
https://pubmed.ncbi.nlm.nih.gov/29315381