Zobrazeno 1 - 7
of 7
pro vyhledávání: '"genetics [Ubiquitination]"'
Publikováno v:
The journal of biological chemistry 295(3), 673-689 (2019). doi:10.1074/jbc.RA119.010617
J Biol Chem
J Biol Chem
Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. The causes for neuropathological TDP-43 ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeb0acdf72640fe456c545974eb3808
https://doi.org/10.1016/s0021-9258(17)49926-1
https://doi.org/10.1016/s0021-9258(17)49926-1
Autor:
Annika Meinander, Meike Broemer, Christa Kietz, Anna L. Aalto, Aravind K. Mohan, Henning Walczak, Lukas Schwintzer, Sebastian Kupka
Publikováno v:
Cell Death and Differentiation
Cell death and differentiation 26(5), 860-876 (2018). doi:10.1038/s41418-018-0164-x
Cell death and differentiation 26(5), 860-876 (2018). doi:10.1038/s41418-018-0164-x
Post-translational modifications such as ubiquitination play a key role in regulation of inflammatory nuclear factor-κB (NF-κB) signalling. The Drosophila IκB kinase γ (IKKγ) Kenny is a central regulator of the Drosophila Imd pathway responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d552b465c1bb317d7b591f7e64c90c16
https://doi.org/10.1038/s41418-018-0164-x
https://doi.org/10.1038/s41418-018-0164-x
Akademický článek
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Autor:
Anna Lechado Terradas, Friederike Hans, Sonia Golombek, Sven Geisler, Caren Linnemann, Etsuro Nakanishi, Lea Jäger, Nicolas Casadei, Philipp J. Kahle
Publikováno v:
Experimental cell research 384(2), 111641 (2019). doi:10.1016/j.yexcr.2019.111641
Parkin is an ubiquitin ligase regulating mitochondrial quality control reactions, including the autophagic removal of depolarized mitochondria (mitophagy). Parkin-mediated protein ubiquitinations may be counteracted by deubiquitinating enzymes (DUBs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9699e494c46184a2a3abb8b9e13a1c01
https://doi.org/10.1016/j.yexcr.2019.111641
https://doi.org/10.1016/j.yexcr.2019.111641
Publikováno v:
Journal of cell science 127(15), 3280-3293 (2014). doi:10.1242/jcs.146035
Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles of E2 ubiquitin-conjugating e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::966a0427a0c799f754fe29e70d446109
https://pubmed.ncbi.nlm.nih.gov/24906799
https://pubmed.ncbi.nlm.nih.gov/24906799
Autor:
Anna Pilsl, Jörg Tatzelt, Daniel Krappmann, Silvana Hrelia, Wolfgang Wurst, Maria Patra, Anne Kathrin Müller-Rischart, Carolin Schweimer, Thomas Langer, Dietrich Trümbach, Gunnar Dittmar, Maria Funke, Alexandra Deinlein, Regina Peis, Patrick Beaudette, Elisa Motori, Konstanze F. Winklhofer, Peer-Hendrik Kuhn, Kamyar Hadian, Stefan F. Lichtenthaler
Publikováno v:
Mol Cell
Molecular cell 49(5), 908-921 (2013). doi:10.1016/j.molcel.2013.01.036
Mol. Cell 49, 908-921 (2013)
Molecular cell 49(5), 908-921 (2013). doi:10.1016/j.molcel.2013.01.036
Mol. Cell 49, 908-921 (2013)
Parkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease, has a wide neuroprotective activity, preventing cell death in various stress paradigms. We identified a stress-protective pathway regulated by parkin that links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f741d75d3bc8ba3566b658fa6f4fc23e
https://hdl.handle.net/21.11116/0000-000B-7ABD-8
https://hdl.handle.net/21.11116/0000-000B-7ABD-8
Autor:
Susanne Dieringer, Stephanie Dorn, Sybille Krauss, Thomas Klockgether, Katrin Zimmermann, Bernd O. Evert, Ullrich Wuellner, Alexander Pfeifer, Peter Breuer, Julieta Araujo
Publikováno v:
Human molecular genetics 20(15), 2928-2941 (2011). doi:10.1093/hmg/ddr197
Ataxin-3 (ATXN3), the disease protein in spinocerebellar ataxia type 3 (SCA3), binds to target gene promoters and modulates transcription by interaction with transcriptional regulators. Here, we show that ATXN3 interacts with the forkhead box O (FOXO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc645678b79cd2b3bcdb0981f471e059
https://pubmed.ncbi.nlm.nih.gov/21536589
https://pubmed.ncbi.nlm.nih.gov/21536589