TIP60/KAT5 is required for neuronal viability in hippocampal CA1

Autor: Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban

Publikováno v: Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444ec66987556cb4c7f6b85293f7171
https://doi.org/10.1038/s41598-019-50927-1

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Autor: George Dedoussis, Rui Li, Elaine G.Y. Chew, George Papanikolaou, Tim D. Spector, David A. Hinds, Susanne Moebus, Asif Javed, Dale R. Nyholt, Axel M. Hillmer, Gérard Waeber, Zoltán Kutalik, Nicholas G. Martin, Michael P. Philpott, Lara M. Hochfeld, Tessel E. Galesloot, Xiu Ting Heng, Rico Rueedi, Thomas Anhalt, Markus M. Nöthen, Dmitriy Drichel, Michael Nothnagel, Stavroula Kanoni, Ralf Paus, Lambertus A. Kiemeney, Christine Herold, Stefanie Heilmann-Heimbach, J. Brent Richards, Tim Becker, Panos Deloukas, Peter Vollenweider, Julian Hecker, Sonali Pechlivanis, Ricardo C.H. del Rosario, Heide Loehlein Fier, Shyam Prabhakar

Publikováno v: Heilmann-Heimbach, S, Herold, C, Hochfeld, L M, Hillmer, A M, Nyholt, D R, Hecker, J, Javed, A, Chew, E G Y, Pechlivanis, S, Drichel, D, Heng, X T, Del Rosario, R C H, Fier, H L, Paus, R, Rueedi, R, Galesloot, T E, Moebus, S, Anhalt, T, Prabhakar, S, Li, R, Kanoni, S, Papanikolaou, G, Kutalik, Z, Deloukas, P, Philpott, M P, Waeber, G, Spector, T D, Vollenweider, P, Kiemeney, L A L M, Dedoussis, G, Richards, J B, Nothnagel, M, Martin, N G, Becker, T, Hinds, D A & Nöthen, M M 2017, ' Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness ', Nature Communications, vol. 8, 14694 . https://doi.org/10.1038/ncomms14694
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications 8(1), 14694 (2017). doi:10.1038/ncomms14694
Nature Communications
Nature Communications, 8, 14694
Nature Communications, 8, pp. 14694
Nature communications, vol. 8, pp. 14694

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c457dad93623b5473179a9e54aca6e3
https://doi.org/10.1038/ncomms14694

Inhibition of p63 Transcriptional Activity by p14ARF: Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

Autor: Antonio Gentilella, Raffaela Santoro, Girolama La Mantia, Gelsomina Mansueto, Luisa Guerrini, Alessandra Pollice, Viola Calabrò, Pamela Ghioni

Publikováno v: Molecular and Cellular Biology. 24:8529-8540

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts with and inhibits the ubiquitin ligase MDM2, resulting in p53 stabilization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac5d074e324426699a49c6af498bd27
https://doi.org/10.1128/mcb.24.19.8529-8540.2004

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