Výsledky vyhledávání - "genetics [Somatostatin]"

Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons

Autor: Susanne, Bauer, Lars, Dittrich, Lech, Kaczmarczyk, Melvin, Schleif, Rui, Benfeitas, Walker S, Jackson

Publikováno v: Life science alliance 5(11), e202201530 (2022). doi:10.26508/lsa.202201530

Selective neuronal vulnerability is common in neurodegenerative diseases but poorly understood. In genetic prion diseases, in-cluding fatal familial insomnia (FFI) and Creutzfeldt-Jakob dis-ease (CJD), different mutations in the Prnp gene manifest as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c4b8a7a346701594a1af39f3bfd1049
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189755

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Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects

Autor: Daniel Müller-Komorowska, Thoralf Opitz, Shehabeldin Elzoheiry, Michaela Schweizer, Eleonora Ambrad Giovannetti, Heinz Beck

Publikováno v: Frontiers in Neural Circuits, Vol 14 (2020)
Frontiers in Neural Circuits
Frontiers in neural circuits 14, 16 (2020). doi:10.3389/fncir.2020.00016

Transgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern neuroscience. The investigation of interneurons in particular has benefitted from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829da04db62026fc47dd5199e0a3666a
https://www.frontiersin.org/article/10.3389/fncir.2020.00016/full

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Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer’s Disease Model

Autor: Manuel Mittag, Jens Wagner, Martin K. Schwarz, Martin Fuhrmann, Julia Steffen, Stefanie Poll, Boris Schmidt, Inna Schwarz, Hans-Rüdiger Geis, Stefan Remy, Lena C. Schmid

Publikováno v: Neuron 92(1), 114-125 (2016). doi:10.1016/j.neuron.2016.08.034

Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network dysfunction, but the underlying mechanisms remain unknown. In the hippocampus, microcircuit activity during learning and memory processes is tightly controlled by O-L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a786719da20288da0170b4830c12de
https://doi.org/10.1016/j.neuron.2016.08.034

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Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

Autor: Lisa Michelle Restelli, Sven Lang, Konstanze F. Winklhofer, Margit Miesbauer, Richard Zimmermann, Daniela Dirndorfer, Natalie V. Pfeiffer, Stephan Frank, Albert Neutzner, Ulrike K. Resenberger, Charles Hemion, Jörg Tatzelt

Publikováno v: The EMBO journal 32(7), 1036-1051 (2013). doi:10.1038/emboj.2013.46
The EMBO journal

Protein targeting to specified cellular compartments is essential to maintain cell function and homeostasis. In eukaryotic cells, two major pathways rely on N-terminal signal peptides to target proteins to either the endoplasmic reticulum (ER) or mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbebae32a3ff94eb819c3f769ccc117
https://pub.dzne.de/record/136864

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