Alpha-synuclein fragments trigger distinct aggregation pathways

Autor: Wolfgang Wurst, Frits Kamp, Günter U. Höglinger, Valentin Evsyukov, Viktoria Ruf, Tasnim Chakroun, Matthias Höllerhage, Thomas W. Rösler, Andreas Schmidt, Niko-Petteri Nykänen

Publikováno v: Cell Death & Disease
Cell Death Dis. 11:84 (2020)
Cell death & disease 11(2), 84 (2020). doi:10.1038/s41419-020-2285-7
Cell Death and Disease, Vol 11, Iss 2, Pp 1-16 (2020)

Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e5ab334ca0ac21d68406a128f81050
http://europepmc.org/articles/PMC6997403

Tau protein liquid-liquid phase separation can initiate tau aggregation

Autor: Zhanyun Fan, Tarun V. Kamath, Anthony A. Hyman, Charles R. Vanderburg, J. Paul Taylor, Bahareh Eftekharzadeh, Amandine Molliex, Bradley T. Hyman, Katarzyna Marta Zoltowska, Katharina Tepper, Rachel E. Bennett, Allyson D. Roe, Pawel R. Laskowski, Susanne Wegmann, Amayra Hernández-Vega, Daniel J. Müller, Caitlin Commins, Eckhard Mandelkow, Simon Dujardin, Danny MacKenzie

Publikováno v: EMBO Journal
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9167a871aa08aef02aee28352f25acf4
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Autor: Nicole, Groh, Ivan, Gallotta, Marie C, Lechler, Chaolie, Huang, Raimund, Jung, Della C, David

Publikováno v: JoVE journal Biology(129), 56464 (2017). doi:10.3791/56464

In the last decades, the prevalence of neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), has grown. These age-associated disorders are characterized by the appearance of protein aggregates with fibrillary str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f9331a1fe485b30cbb1aa6fa5233d53

Dry entrapment of enzymes by epoxy or polyester resins hardened on different solid supports

Autor: K. Peter Stahmann, Andreas Funke, Andrea Merseburg, Klaus Schnitzlein, Susann Barig

Publikováno v: Enzyme and microbial technology 60, 47-55 (2014). doi:10.1016/j.enzmictec.2014.03.013

Embedding of enzymes was performed with epoxy or polyester resin by mixing in a dried enzyme preparation before polymerization was started. This fast and low-cost immobilization method produced enzymatically active layers on different solid supports.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68853327babaa4643aaf0f0dc73d9385
https://doi.org/10.1016/j.enzmictec.2014.03.013

Horizontal Transmission of Cytosolic Sup35 Prions by Extracellular Vesicles

Autor: Philip Denner, Ina Vorberg, Julia Hofmann, André Hossinger, Shu Liu

Publikováno v: mBio, Vol 7, Iss 4, p e00915-16 (2016)
mBio, Vol 7, Iss 4 (2016)
mBio 7(4), e00915-16/mbio/7/4/e00915-16.atom (2016). doi:10.1128/mBio.00915-16
mBio

Prions are infectious protein particles that replicate by templating their aggregated state onto soluble protein of the same type. Originally identified as the causative agent of transmissible spongiform encephalopathies, prions in yeast (Saccharomyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f17a73127f94bd33a53fd6980a35be
http://mbio.asm.org/cgi/content/full/7/4/e00915-16