Zobrazeno 1 - 10
of 36
pro vyhledávání: '"genetics [Receptors, Immunologic]"'
Autor:
Morenas-Rodríguez, Estrella, Li, Yan, Hassenstab, Jason, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Feederle, Regina, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Karch, Celeste M, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Schlepckow, Kai, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, Haass, Christian, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Franzmeier, Nicolai, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Xiong, Chengjie, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Suarez-Calvet, Marc, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fagan, Anne M, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Schultz, Stephanie, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Gordon, Brian A, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Benzinger, Tammie L S, Jack, Clifford, Jerome, Gina, Johnson, Erik, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William Bill, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke
Publikováno v:
The lancet / Neurology 21(4), 329-341 (2022). doi:10.1016/S1474-4422(22)00027-8
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its e
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Autor:
Valerie L. Sim, José Eriton Gomes da Cunha, Niels Kruse, Óscar López-Pérez, Katrin Thüne, Enric Vidal, Peter Hermann, Inga Zerr, Miguel Calero, Henrik Zetterberg, Daniela Diaz-Lucena, Matthias Schmitz, Anna Villar-Piqué, Franc Llorens, Hailey Pineau, Alba Marín-Moreno, Raquel Sánchez-Valle, Joachim Riggert, José Antonio del Río, Kaj Blennow, Pol Andrés-Benito, Juan María Torres, Isidre Ferrer, Brit Mollenhauer, Anna Ladogana, Juan Carlos Espinosa
Publikováno v:
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Acta neuropathologica 141(6), 841-859 (2021). doi:10.1007/s00401-021-02296-1
Repisalud
Instituto de Salud Carlos III (ISCIII)
Acta Neuropathologica
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Acta neuropathologica 141(6), 841-859 (2021). doi:10.1007/s00401-021-02296-1
Repisalud
Instituto de Salud Carlos III (ISCIII)
Acta Neuropathologica
19 Pág. Centro de Investigación en Sanidad Animal (CISA)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several ne
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several ne
Autor:
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl‐Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass
Publikováno v:
The EMBO journal 41(4), e109108 (2022). doi:10.15252/embj.2021109108
Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition. To understand the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561d67316e9f278a34f08b959e8dd608
https://pub.dzne.de/record/163471
https://pub.dzne.de/record/163471
Autor:
Annemarie Luise Kühn, Stefan Frenzel, Alexander Teumer, Katharina Wittfeld, Linda Garvert, Antoine Weihs, Georg Homuth, Holger Prokisch, Robin Bülow, Matthias Nauck, Uwe Völker, Henry Völzke, Hans Jörgen Grabe, Sandra Van der Auwera
Publikováno v:
International journal of molecular sciences 23(22), 13764 (2022). doi:10.3390/ijms232213764
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13764
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13764
Although the common pathology of Alzheimer’s disease (AD) and white matter hyperintensities (WMH) is disputed, the gene TREML2 has been implicated in both conditions: its whole-blood gene expression was associated with WMH volume and its missense v
Autor:
Christian Haass
Publikováno v:
Neuron 109(8), 1243-1245 (2021). doi:10.1016/j.neuron.2021.03.029
TREM2 variants increase the risk for Alzheimer's disease. In this issue of Neuron, Lee et al. demonstrate that TREM2-dependent microglial functions prevent accumulation and spreading of tau, but only in the presence of amyloid pathology. This provide
Autor:
Hannah Scheiblich, Peter St George-Hyslop, Jochen Walter, Nàdia Villacampa, Michael T. Heneka, Samira Parhizkar, Pranav Joshi, Seema Qamar, Sandra Theil, Florian Riffel, Kanayo Satoh, Paul E. Fraser, Christian Haass, Masahiro Enomoto, Sathish Kumar
Publikováno v:
Glia
Glia 69(12), 2917-2932 (2021). doi:10.1002/glia.24077
Glia 69(12), 2917-2932 (2021). doi:10.1002/glia.24077
Funder: Canadian Institutes of Health Research; Id: http://dx.doi.org/10.13039/501100000024
Funder: Alzheimer's Association (Zenith Award)
Funder: UK Alzheimer Society and ARUK
Funder: Wellcome Trust Collaborative Award in Science
Funder: Alzheimer's Association (Zenith Award)
Funder: UK Alzheimer Society and ARUK
Funder: Wellcome Trust Collaborative Award in Science
Autor:
Joshi, Pranav, Riffel, Florian, Kumar, Sathish, Villacampa, Nàdia, Theil, Sandra, Parhizkar, Samira, Haass, Christian, Colonna, Marco, Heneka, Michael T., Arzberger, Thomas, Herms, Jochen, Walter, Jochen
Publikováno v:
Acta Neuropathologica Communications 9(1), 168 (2021). doi:10.1186/s40478-021-01263-x
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-22 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-22 (2021)
Acta Neuropathologica Communications
Progressive accumulation of Amyloid-β (Aβ) deposits in the brain is a characteristic neuropathological hallmark of Alzheimer’s disease (AD). During disease progression, extracellular Aβ plaques undergo specific changes in their composition by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b01a4c76673e077f41e325d356a3e378
https://pub.dzne.de/record/162686
https://pub.dzne.de/record/162686
Autor:
Carina C. de Oliveira Mann, Stefan Endres, Stefan F. Lichtenthaler, Max Schnurr, Meino Rohlfs, Simon Rothenfusser, Daniel F. R. Boehmer, Philipp Metzger, Christine Hörth, Karl-Peter Hopfner, Lorenz Kocheise, Caroline C. Friedel, Michael Kluge, Simone Formisano, Lars M. Koenig, Peter Duewell, Stephan Mueller
Publikováno v:
Science immunology 6(61), eabe2550 (2021). doi:10.1126/sciimmunol.abe2550
Cytoplasmic double-stranded RNA is sensed by RIG-I-like receptors (RLRs), leading to induction of type I interferons (IFN-Is), proinflammatory cytokines, and apoptosis. Here, we elucidate signaling mechanisms that lead to cytokine secretion and cell
Autor:
Joseph W. Lewcock, Sabina Tahirovic, Gilbert Di Paolo, Kathryn M. Monroe, Christian Haass, Kai Schlepckow
Publikováno v:
Neuron 108(5), 801-821 (2020). doi:10.1016/j.neuron.2020.09.029
Neuron
Neuron
Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow cognitive decline have not yet been successful. Many of these approaches have targeted the amyloid cascade, indicating that novel treatment strategies are req