Zobrazeno 1 - 10 of 19 pro vyhledávání: '"genetics [RNA, Small Interfering]"'
1
Charcot–Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages
Autor: Bernardo S. Franklin, Christine Schmitt-Mabmunyo, Marco A. Ataide, Wolfgang Kastenmüller, Gudrun Engels, Juan F. Rodriguez-Alcazar, Natalio Garbi, Eicke Latz
Publikováno v: The journal of immunology 202(2), 550-558 (2018). doi:10.4049/jimmunol.1800107
Charcot–Leyden crystals (CLCs) are Galectin-10 protein crystals that can form after eosinophils degranulate. CLCs can appear and persist in tissues from patients with eosinophilic disorders, such as asthma, allergic reactions, and fungal and helmin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ddb9d40b91187427c65411993cfeab
https://doi.org/10.4049/jimmunol.1800107
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2
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Autor: Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publikováno v: Nature Communications 12(1), 4584 (2021). doi:10.1038/s41467-021-24817-y
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc49410437957521bf8a06e7e4be82f2
https://pub.dzne.de/record/162717
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3
A combined miRNA-piRNA signature to detect Alzheimer's disease
Autor: Walter Maetzler, Mathis Synofzik, Claudia Schulte, Pooja Rao, Susanne Burkhardt, Tonatiuh Pena Centeno, Christian Deuschle, Ivana Delalle, Oliver Peters, Gaurav Jain, Andre Fischer, Tea Berulava, Lalit Kaurani, Johannes Kornhuber, Michael Hüll, Brit Mollenhauer, Jens Wiltfang, Anne Stuendl, Wolfgang Maier, Hermann Esselmann, Anja Schneider
Publikováno v: Translational Psychiatry 9(1), 250 (2019). doi:10.1038/s41398-019-0579-2
Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019)
Alzheimer’s disease (AD) is the most common neurodegenerative disorder causing huge emotional and economic burden to our societies. An effective therapy has not been implicated yet, which is in part also due to the fact that pathological changes oc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0090e780013b59264f5ee3fb6ebb7de
https://pub.dzne.de/record/141576
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4
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
Autor: Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric
Publikováno v: Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of Parkinson's disease (PD). However, LRRK2 function and molecular mechanisms causing the parkinsonian phenotype remain widely unknown. Most of LRRK2 k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba353f29c2943ab3f209bd31a5e546
https://doi.org/10.1016/j.bbadis.2013.09.009
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5
Systems genetics analysis of a recombinant inbred mouse cell culture panel reveals Wnt pathway member Lrp6 as a regulator of adult hippocampal precursor cell proliferation
Autor: Gerardo Ramírez-Rodríguez, Gerd Kempermann, Zeina Nicola, Kathrin Saar, Norbert Hubner, Rupert W. Overall, Muhammad Ichwan, Suresh Kannan, Anna N. Grzyb, Giannino Patone
Publikováno v: Stem cells 34(3), 674-684 (2016). doi:10.1002/stem.2313
In much animal research, genetic variation is rather avoided than used as a powerful tool to identify key regulatory genes in complex phenotypes. Adult hippocampal neurogenesis is one such highly complex polygenic trait, for which the understanding o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7617f37822733b41b52128428eef606d
http://edoc.mdc-berlin.de/15457/1/15457oa.pdf
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6
Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network
Autor: Lisaweta Roßmannek, Hernán E. Grecco, Jutta Luig, Philippe I. H. Bastiaens, Rabea Stockert, Amit Mhamane, Pedro Roda-Navarro, Angel Stanoev, Sven Fengler, Klaus C. Schuermann, Wayne Stallaert, Maitreyi S. Joshi, Aneta Koseska, Martin Baumdick, Yannick Brüggemann
Publikováno v: Cell systems 7(3), 295-309.e11 (2018). doi:10.1016/j.cels.2018.06.006
Cell Systems
Summary The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d662ce7859bce68bf67dfe1440ddfe
https://doi.org/10.1016/j.cels.2018.06.006
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7
Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
Autor: Karina Kloos, Christian Haass, Frank Vogel, Kerstin Lämmermann, Andreas S. Reichert, Lena Bouman, Julia S. Schlehe, Bettina Brunner, Wolfgang Wurst, Annerose Kurz-Drexler, A. Kathrin Lutz, Daniela Vogt-Weisenhorn, Mareike E. Fett, Nicole Exner, Konstanze F. Winklhofer, Jörg Tatzelt
Publikováno v: J. Biol. Chem. 284, 2108-2111 (2009)
The journal of biological chemistry 284(34), 22938-22951 (2009). doi:10.1074/jbc.M109.035774
Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to mitochondrial pathology in human cells and Drosophila melanogaster, which can b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c33d1f99c997e4a059702b425b71bd
https://doi.org/10.1074/jbc.m109.035774
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8
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
Autor: Frank Maus, Dominik Sakry, Fabien Binamé, Khalad Karram, Krishnaraj Rajalingam, Colin Watts, Richard Heywood, Rejko Krüger, Judith Stegmüller, Hauke B Werner, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Jacqueline Trotter
Publikováno v: PLOS ONE 10(9), e0137311 (2015). doi:10.1371/journal.pone.0137311
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0137311 (2015)
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a702c46cc767bfcb3d3585e584f35159
https://pub.dzne.de/record/138091
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9
PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy
Autor: Chantal A. Mutsaers, Ellen J. Bennett, Basil Sharrack, Ke Ning, Chiara F. Valori, Pamela J. Shaw, Thomas H. Gillingwater, Daniel Little, Matthew Wyles, Mimoun Azzouz
Publikováno v: Molecular therapy 23(2), 270-277 (2015). doi:10.1038/mt.2014.209
Molecular Therapy
Spinal muscular atrophy (SMA) is the second most common genetic cause of death in childhood. However, no effective treatment is available to halt disease progression. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene. We previousl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c6a58dc4d1cf5585d92ae8ca450a18
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10
The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy
Autor: Geisler, Sven, Vollmer, Stefanie, Golombek, Sonia, Kahle, Philipp J
Publikováno v: Journal of cell science 127(15), 3280-3293 (2014). doi:10.1242/jcs.146035
Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles of E2 ubiquitin-conjugating e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::966a0427a0c799f754fe29e70d446109
https://pubmed.ncbi.nlm.nih.gov/24906799
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