Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization

Autor: Pragya Pathak, Krista K. Alexander, Leah G. Helton, Michalis Kentros, Timothy J. LeClair, Xiaojuan Zhang, Franz Y. Ho, Timothy T. Moore, Scotty Hall, Giambattista Guaitoli, Christian Johannes Gloeckner, Arjan Kortholt, Hardy Rideout, Eileen J. Kennedy

Publikováno v: ACS chemical neuroscience, 14(11):00259, 1971-1980. AMER CHEMICAL SOC
ACS chemical neuroscience 14(11), 1971-1980 (2023). doi:10.1021/acschemneuro.3c00259

Missense mutations along the leucine-rich repeat kinase 2 (LRRK2) protein are a major contributor to Parkinson's Disease (PD), the second most commonly occurring neurodegenerative disorder worldwide. We recently reported the development of allosteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc0614f15090c6912f4e8e56ac13db4
https://research.rug.nl/en/publications/8b0f169c-49a7-4d9a-a76d-669929bf4f40

Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population

Autor: Kevin Kirchner, Linda Garvert, Katharina Wittfeld, Sabine Ameling, Robin Bülow, Henriette Meyer zu Schwabedissen, Matthias Nauck, Henry Völzke, Hans J. Grabe, Sandra Van der Auwera

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1120
International journal of molecular sciences 24(2), 1120 (2023). doi:10.3390/ijms24021120

The aim of this study was to disentangle the effects of various genetic factors on hippocampal subfield volumes using three different approaches: a biologically driven candidate gene approach, a hypothesis-free GWAS approach, and a polygenic approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf420e3302e512e5c4763ec550048802

The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1

Autor: Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang

Publikováno v: Nat Cell Biol
Nature cell biology, vol 24, iss 1

Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and various diseases. Here we show that the Hippo pathway plays a critical role in regulating heavy metal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72fa5595c58c2af5bb74b636342fb0
https://europepmc.org/articles/PMC9022944/

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Autor: W. Samantha N. Jayasekara, Cynthia Louis, Hassan Albargy, Kevin Luu, Katherine A. Fitzgerald, Francis J. Kirby, Finbar Mansell, Jesse J. Balic, Daniel J. Garama, Eicke Latz, Fiachra Humphries, Ashley Mansell, Nikola Baschuk, Daniel J. Gough, Dominic De Nardo

Publikováno v: Nature Communications 11(1), 3816 (2020). doi:10.1038/s41467-020-17669-5
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor (TLR)-4 expressed on macrophages induces a robust pro-inflammatory response which has recently been shown to be dependent on metabolic reprogramming 1, 2, 3, 4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d96f36776d72d1c4575633c91b3361

Comprehensive analysis of the mutation spectrum in 301 German ALS families

Autor: Müller, Kathrin, Brenner, David, Kubisch, Christian, Klopstock, Thomas, Zeller, Daniel, Jablonka, Sibylle, Sendtner, Michael, Klebe, Stephan, Knehr, Antje, Günther, Kornelia, Weis, Joachim, Claeys, Kristl G, Weydt, Patrick, Schrank, Berthold, Sperfeld, Anne-Dorte, Hübers, Annemarie, Otto, Markus, Dorst, Johannes, Meitinger, Thomas, Strom, Tim M, Andersen, Peter M, Ludolph, Albert, Weishaupt, Jochen H, Meyer, Thomas, MND-NET, German ALS network, Weyen, Ute, Hermann, Andreas, Regensburger, Martin, Winkler, Jürgen, Linker, Ralf, Winner, Beate, Hagenacker, Tim, Koch, Jan Christoph, Lingor, Paul, Grehl, Torsten, Göricke, Bettina, Zierz, Stephan, Jordan, Berit, Baum, Petra, Wolf, Joachim, Winkler, Andrea, Young, Peter, Bogdahn, Ulrich, Prudlo, Johannes, Kassubek, Jan, Petri, Susanne, Danzer, Karin M, Grosskreutz, Julian, Schuster, Joachim, Volk, Alexander E, Borck, Guntram

Publikováno v: Journal of neurology, neurosurgery, and psychiatry 89(8), 817-827 (2018). doi:10.1136/jnnp-2017-317611
Journal of Neurology, Neurosurgery, and Psychiatry
J. Neurol. Neurosurg. Psychiatr. 89, 817-827 (2018)

ObjectivesRecent advances in amyotrophic lateral sclerosis (ALS) genetics have revealed that mutations in any of more than 25 genes can cause ALS, mostly as an autosomal-dominant Mendelian trait. Detailed knowledge about the genetic architecture of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbb9591c55245bd90ac99345f5b547b
https://pub.dzne.de/record/140154