Zobrazeno 1 - 6
of 6
pro vyhledávání: '"genetics [Protein Aggregates]"'
Autor:
Stefan Becker, Marija Rankovic, Filippo Favretto, Alain Ibáñez de Opakua, Markus Zweckstetter, Maria Babu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature Communications
Nature Communications 12(1), 3396 (2021). doi:10.1038/s41467-021-23691-y
Nature Communications
Nature Communications 12(1), 3396 (2021). doi:10.1038/s41467-021-23691-y
Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with overlapping clinical features and the pathological hallmark of cytoplasmic deposits of misfolded proteins. The most frequent cause of familial forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b336ce3b4dc83b67e1949bd86c1b9a41
https://hdl.handle.net/11562/1060678
https://hdl.handle.net/11562/1060678
Autor:
Haenig, C., Atias, N., Taylor, A.K., Mazza, A., Schaefer, M.H., Russ, J., Riechers, S.P., Jain, S., Coughlin, M., Fontaine, J.F., Freibaum, B.D., Brusendorf, L., Zenkner, M., Porras, P., Stroedicke, M., Schnoegl, S., Arnsburg, K., Boeddrich, A., Pigazzini, L., Heutink, P., Taylor, J.P., Kirstein, J., Andrade-Navarro, M.A., Sharan, R., Wanker, E.E.
Publikováno v:
Cell reports 32(7), 108050-(2020). doi:10.1016/j.celrep.2020.108050
Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fb105c60f1c4affce2edd06e689d182
https://pubmed.ncbi.nlm.nih.gov/32814053
https://pubmed.ncbi.nlm.nih.gov/32814053
Autor:
Romina Bester, Peer-Hendrik Kuhn, Katrin Riemschoss, Ina Vorberg, Yvonne Duernberger, Shu Liu, Manuel Schölling, Lydia Paulsen, Stefan F. Lichtenthaler
Publikováno v:
Molecular and cellular biology 38(15), e00111-18/mcb/38/15/e00111-18.atom (2018). doi:10.1128/MCB.00111-18
Molecular and Cellular Biology
Molecular and Cellular Biology
Prions of lower eukaryotes are transmissible protein particles that propagate by converting homotypic soluble proteins into growing protein assemblies. Prion activity is conferred by so-called prion domains, regions of low complexity that are often e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbf420e5df9adf24dccf7fed0d4ab1f
https://mediatum.ub.tum.de/doc/1525805/document.pdf
https://mediatum.ub.tum.de/doc/1525805/document.pdf
Autor:
Florian Wegner, Arun Pal, Xenia Lojewski, Peter Reinhardt, Susanne Petri, Jared Sterneckert, Philippe Corcia, Andreas Hermann, Nicole Kreiter, Maximilian Naujock, Alexander Storch
Publikováno v:
Neurobiology of Disease, Vol 115, Iss, Pp 167-181 (2018)
Neurobiology of disease 115, 167-181 (2018). doi:10.1016/j.nbd.2018.03.010
Neurobiology of disease 115, 167-181 (2018). doi:10.1016/j.nbd.2018.03.010
TAR DNA-binding protein 43 (TDP43) is a cause of familiar and sporadic amyotrophic lateral sclerosis (ALS). The diverse postulated mechanisms by which TDP43 mutations cause the disease are not fully understood. Human wildtype and TDP43 S393L and G294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f38608e9ff35eea6064a5849b323060
https://doi.org/10.1101/218610
https://doi.org/10.1101/218610
Autor:
Tatenhorst, Lars, Eckermann, Katrin, Outeiro, Tiago F, Zweckstetter, Markus, Lingor, Paul, Dambeck, Vivian, Fonseca-Ornelas, Luis, Walle, Hagen, Lopes da Fonseca, Tomás, Koch, Jan C, Becker, Stefan, Tönges, Lars, Bähr, Mathias
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. Since alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e25ac157886f125890f1f46489256178
https://pubmed.ncbi.nlm.nih.gov/27101974
https://pubmed.ncbi.nlm.nih.gov/27101974
Autor:
Markus Zweckstetter, Nasrollah Rezaei-Ghaleh, Patrick Wunderlich, Dietmar Rudolf Thal, Jochen Walter, Thomas A. Bayer, Sathish Kumar, Kathrin Stüber, Sandra Theil, Philipp Koch, Oliver Brüstle, Oliver Wirths
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0728842bd419776cad0530d485f5eb0
https://lirias.kuleuven.be/handle/123456789/545197
https://lirias.kuleuven.be/handle/123456789/545197