Zobrazeno 1 - 10
of 11
pro vyhledávání: '"genetics [Presenilin-2]"'
Autor:
David M. Holtzman, Tammie L.S. Benzinger, Peter R. Schofield, Christian la Fougère, Johannes Levin, Jasmeer P. Chhatwal, Michael M Weiner, Andrew J. Saykin, Clifford R. Jack, Guoqiao Wang, Brian A. Gordon, Chengjie Xiong, Colin L. Masters, Anne M. Fagan, Stephen Salloway, Shaney Flores, Neill R. Graff-Radford, John C. Morris, Randall J. Bateman, Nick C. Fox, Jon Christensen, Daniel S. Marcus, Beau M. Ances, Russ C. Hornbeck, Yi Su, Tyler Blazey, Adam M. Brickman, David M. Cash, Martin N. Rossor, Sarah B. Berman, Stephen Correia, Paul M. Thompson, Stefan Förster, Amrita Hari-Raj, Nigel J. Cairns, Eric McDade, Jason Hassenstab, Marcus E. Raichle, Katrina L. Paumier, Aylin Dincer
Publikováno v:
The Lancet. Neurology, vol 17, iss 3
The Lancet. Neurology
The lancet / Neurology 17(3), 241-250 (2018). doi:10.1016/S1474-4422(18)30028-0
The Lancet. Neurology
The lancet
Summary Background Models of Alzheimer's disease propose a sequence of amyloid β (Aβ) accumulation, hypometabolism, and structural decline that precedes the onset of clinical dementia. These pathological features evolve both temporally and spatiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd9d5eb44c48077889e21729529b40
https://escholarship.org/uc/item/8vb08570
https://escholarship.org/uc/item/8vb08570
Autor:
Josef Priller, Daniel Janowitz, Johannes Levin, Miguel Ángel Araque Caballero, Henning Boecker, Christiana Franke, Anne M. Fagan, Frank Jessen, Martin Dichgans, Jens Wiltfang, Michael T. Heneka, Christian Haass, Michael W. Weiner, Alison Goate, Peter Falkai, Daniel Bittner, Felix Menne, Marc Suárez-Calvet, Anja Schneider, Barbara Kofler, Oliver Peters, Eike Jakob Spruth, Marco Duering, Michael Wagner, Stefan J. Teipel, Colin L. Masters, Oliver Speck, Robert Perneczky, Peter J. Nestor, Tammie L.S. Benzinger, Coraline D. Metzger, Frederic Brosseron, Jae-Hong Lee, Manuel Fuentes, Christine Westerteicher, Jasmeer P. Chhatwal, Cihan Catak, Katrina L. Paumier, Claudia Bartels, Martin N. Rossor, Adrian Danek, Stephen Salloway, Mathias Jucker, Ingo Kilimann, Klaus Fliessbach, Peter R. Schofield, Alfredo Ramirez, Nicolai Franzmeier, Annika Spottke, Emrah Düzel, Steffen Wolfsgruber, Katharina Buerger, Christoph Laske, John C. Morris, Randall J. Bateman, Michael Ewers
Publikováno v:
Franzmeier, N, Düzel, E, Jessen, F, Buerger, K, Levin, J, Duering, M, Dichgans, M, Haass, C, Suárez-Calvet, M, Fagan, A M, Paumier, K, Benzinger, T, Masters, C L, Morris, J C, Perneczky, R, Janowitz, D, Catak, C, Wolfsgruber, S, Wagner, M, Teipel, S, Kilimann, I, Ramirez, A, Rossor, M, Jucker, M, Chhatwal, J, Spottke, A, Boecker, H, Brosseron, F, Falkai, P, Fliessbach, K, Heneka, M T, Laske, C, Nestor, P, Peters, O, Fuentes, M, Menne, F, Priller, J, Spruth, E J, Franke, C, Schneider, A, Kofler, B, Westerteicher, C, Speck, O, Wiltfang, J, Bartels, C, Araque Caballero, M Á, Metzger, C, Bittner, D, Weiner, M, Lee, J-H, Salloway, S, Danek, A, Goate, A, Schofield, P R, Bateman, R J & Ewers, M 2018, ' Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease ', Brain . https://doi.org/10.1093/brain/awy008
Brain 141(4), 1186-1200 (2018). doi:10.1093/brain/awy008
Brain
Brain : a journal of neurology, vol 141, iss 4
Brain 141(4), 1186-1200 (2018). doi:10.1093/brain/awy008
Brain
Brain : a journal of neurology, vol 141, iss 4
The neural basis of reserve capacity in Alzheimer’s disease is yet to be fully determined. Franzmeier et al. show that greater left frontal hub connectivity within the fronto-parietal control network is associated with greater resilience of cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a39beaee80ce97ecdd7994cf07462c2
https://hdl.handle.net/20.500.11820/7d9f815b-48f9-45c1-976f-c83dfa0b4cab
https://hdl.handle.net/20.500.11820/7d9f815b-48f9-45c1-976f-c83dfa0b4cab
Autor:
Kevin Taddei, Michael W. Weiner, Belinda M. Brown, Hamid R. Sohrabi, Jeremiah J. Peiffer, Colin L. Masters, Chengjie Xiong, Tammie L.S. Benzinger, Neill R. Graff-Radford, Christoph Laske, Peter R. Schofield, Virginia Buckles, Stephanie R. Rainey-Smith, James M. Noble, Jonathan Vöglein, Roger Clarnette, Anne M. Fagan, Martin N. Rossor, Ralph N. Martins, Samantha L. Gardener, Stephen Salloway, Nigel J. Cairns, John C. Morris, Randall J. Bateman, Tejal M. Shah, Kirk I. Erickson
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 13, iss 11
Alzheimer's and dementia 13(11), 1197-1206 (2017). doi:10.1016/j.jalz.2017.03.008
Alzheimer's and dementia 13(11), 1197-1206 (2017). doi:10.1016/j.jalz.2017.03.008
Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8b74b9a8256ec014881f56da6ec51c
https://escholarship.org/uc/item/4x05j8kv
https://escholarship.org/uc/item/4x05j8kv
Autor:
McDade, Eric, Wang, Guoqiao, Marcus, Daniel S, Morris, John C, Paumier, Katrina, Xiong, Chengjie, Allegri, Ricardo, Berman, Sarah B, Klunk, William, Noble, James, Ringman, John, Ghetti, Bernardino, Gordon, Brian A, Farlow, Martin, Sperling, Reisa A, Chhatwal, Jasmeer, Salloway, Stephen, Graff-Radford, Neill R, Schofield, Peter R, Masters, Colin, Rossor, Martin N, Fox, Nick C, Levin, Johannes, Hassenstab, Jason, Jucker, Mathias, Bateman, Randall J, Network, Dominantly Inherited Alzheimer, Fague, M Scot, Jack, Clifford, Koeppe, Robert, Benzinger, Tammie L S, Buckles, Virginia, Fagan, Anne M, Holtzman, David M, Cairns, Nigel J, Goate, Alison M
Publikováno v:
Neurology 91(14), e1295-e1306 (2018). doi:10.1212/WNL.0000000000006277
ObjectiveTo assess the onset, sequence, and rate of progression of comprehensive biomarker and clinical measures across the spectrum of Alzheimer disease (AD) using the Dominantly Inherited Alzheimer Network (DIAN) study and compare these to cross-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699d4cdd970e5a75912bf902a26f7b56
https://pubmed.ncbi.nlm.nih.gov/30217935
https://pubmed.ncbi.nlm.nih.gov/30217935
Autor:
Peter Heutink, Benjamin Bender, Florian Metzger, Thomas Gasser, Matthis Synofzik, Walter Maetzler, Iris E. Jansen, Cornelis Blauwendraat, Patrizia Rizzu, Claudia Schulte, Javier Simón-Sánchez, Carlo Wilke
Publikováno v:
Blauwendraat, C, Wilke, C, Jansen, I E, Schulte, C, Simón-Sánchez, J, Metzger, F G, Bender, B, Gasser, T, Maetzler, W, Rizzu, P, Heutink, P & Synofzik, M 2016, ' Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants ', Neurobiology of Aging, vol. 37, pp. 208.e11-208.e18 . https://doi.org/10.1016/j.neurobiolaging.2015.09.016
Neurobiology of Aging, 37, 208.e11-208.e18. Elsevier Inc.
Neurobiology of aging 37, 208.e11-208.e17 (2016). doi:10.1016/j.neurobiolaging.2015.09.016
Neurobiology of Aging, 37, 208.e11-208.e18. Elsevier Inc.
Neurobiology of aging 37, 208.e11-208.e17 (2016). doi:10.1016/j.neurobiolaging.2015.09.016
Early-onset Alzheimer's disease (EOAD) accounts for 1%-2% of all Alzheimer's disease (AD) subjects, with large variation in the reported genetic contribution of known dementia genes. In this pilot study, we genetically characterized a German EOAD coh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcd0aeb7e7b4f16b9e04dec6b64e8cc
https://research.vumc.nl/en/publications/dee9e68f-01b2-47e0-8933-378e6630880b
https://research.vumc.nl/en/publications/dee9e68f-01b2-47e0-8933-378e6630880b
Autor:
Lee, Seonjoo, Viqar, Fawad, Cairns, Nigel J, Holtzman, David M, Buckles, Virginia, Ghetti, Bernardino, McDade, Eric, Martins, Ralph N, Saykin, Andrew J, Masters, Colin L, Ringman, John M, Ryan, Natalie S, Zimmerman, Molly E, Förster, Stefan, Laske, Christoph, Schofield, Peter R, Sperling, Reisa A, Salloway, Stephen, Correia, Stephen, Jack, Clifford, Weiner, Michael, Bateman, Randall J, Morris, John C, Narkhede, Atul, Mayeux, Richard, Brickman, Adam M, Network, Dominantly Inherited Alzheimer, Tosto, Giuseppe, Benzinger, Tammie L S, Marcus, Daniel S, Fagan, Anne M, Goate, Alison, Fox, Nick C
Publikováno v:
Annals of neurology 79(6), 929-939 (2016). doi:10.1002/ana.24647
White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::96e1730828d1f8d0f20aa8e184421ffa
https://pubmed.ncbi.nlm.nih.gov/27016429
https://pubmed.ncbi.nlm.nih.gov/27016429
Autor:
Wang, Fen, Gordon, Brian A, McDade, Eric, Ringman, John M, Graff-Radford, Neill R, Ghetti, Bernardino, Farlow, Martin R, Sperling, Reisa, Salloway, Steve, Schofield, Peter R, Masters, Colin L, Martins, Ralph N, Ryman, Davis C, Rossor, Martin N, Jucker, Mathias, Danek, Adrian, Förster, Stefan, Lane, Christopher A S, Morris, John C, Benzinger, Tammie L S, Bateman, Randall J, Network, Dominantly Inherited Alzheimer, Ma, Shengmei, Xiong, Chengjie, Hassenstab, Jason, Goate, Alison, Fagan, Anne M, Cairns, Nigel J, Marcus, Daniel S
Publikováno v:
Neurology 85(9), 790-798 (2015). doi:10.1212/WNL.0000000000001903
Objective: To investigate the associations of cerebral amyloidosis with concurrent cognitive performance and with longitudinal cognitive decline in asymptomatic and symptomatic stages of autosomal dominant Alzheimer disease (ADAD). Methods: Two hundr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21579dcab61c7838b17acc56b1b42d8
https://pubmed.ncbi.nlm.nih.gov/26245927
https://pubmed.ncbi.nlm.nih.gov/26245927
Autor:
Armin Giese, Kamran Honarnejad, Boris Schmidt, Alexander Daschner, Jacek Kuznicki, Jochen Herms, Aleksandra Szybinska, Andrea Zall
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80645 (2013)
PLoS ONE
PLOS ONE 8(11), e80645 (2013). doi:10.1371/journal.pone.0080645
PLoS ONE
PLOS ONE 8(11), e80645 (2013). doi:10.1371/journal.pone.0080645
Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4702a56faa0fbe5632e22fd2a506f1
http://europepmc.org/articles/PMC3829862?pdf=render
http://europepmc.org/articles/PMC3829862?pdf=render
Publikováno v:
The journal of neuroscience 30(23), 7853-7862 (2010). doi:10.1523/JNEUROSCI.1443-10.2010
Presenilin (PS1 or PS2) is the catalytic component of the gamma-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid beta-peptide. PS is cleaved during complex assembly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc1f3f66749c86766713d61befef006
https://pubmed.ncbi.nlm.nih.gov/20534834
https://pubmed.ncbi.nlm.nih.gov/20534834
Autor:
Sven Lammich, Christian Haass, Akio Fukumori, Harald Steiner, Blanca Isabel Pérez-Revuelta, Aya Yamasaki
Publikováno v:
Journal of neurochemistry 112(4), 940-950 (2010). doi:10.1111/j.1471-4159.2009.06510.x
gamma-Secretase is a pivotal intramembrane-cleaving protease complex and important drug target for Alzheimer's disease. The protease not only releases small peptides, such as the amyloid-beta peptide, which drives Alzheimer's disease pathogenesis, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe207915062443b851f54b28278d6a1
https://pubmed.ncbi.nlm.nih.gov/20021564
https://pubmed.ncbi.nlm.nih.gov/20021564