Zobrazeno 1 - 10 of 11 pro vyhledávání: '"genetics [Plaque, Amyloid]"'
1
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease
Autor: Bernardino Ghetti, Erik Portelius, Kaj Blennow, Adrian L. Oblak, Jasmin Mahler, Nick C. Fox, Lisa M. Häsler, Per Hammarström, Natalie Beschorner, K. Peter R. Nilsson, Stephan A. Kaeser, Tammaryn Lashley, Lary C. Walker, Jay Rasmussen, Diego Sepulveda-Falla, Matthias Staufenbiel, Sofie Nyström, Mathias Jucker, Markus Glatzel, Frank Baumann
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 114(49), 13018-13023 (2017). doi:10.1073/pnas.1713215114
The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes. When bound to amyloid, LCOs yield fluorescence emission spectra that reflect the 3D structu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3d0e8d1f9bf7f7e58a153b9ac589d6
https://doi.org/10.1073/pnas.1713215114
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2
Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis
Autor: Javier Rueda-Carrasco, Paula Garcia-Esparcia, Inmaculada Crespo, José A. Esteban, Juan Fortea, Pilar Esteve, José M. Valpuesta, Alberto Lleó, Guadalupe Pereyra, Estrella Gómez-Tortosa, María Jesús Martín-Bermejo, Isidro Ferrer, Mercedes Domínguez, Jonathan E. Draffin, Paola Bovolenta, Inmaculada Moreno, Daniel Alcolea, Alberto Rábano, Ester Aso, África Sandonís, Michael T. Heneka, María Inés Mateo
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature reviews / Neuroscience 22(8), 1258-1268 (2019). doi:10.1038/s41593-019-0432-1
NATURE NEUROSCIENCE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer’s disease (AD). Alternative APP processing v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a0f9a5692c67f30d39b2f9105c61ff
http://hdl.handle.net/10261/193936
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3
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Autor: Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass
Publikováno v: Nature neuroscience
Nature reviews / Neuroscience 22(2), 191-204 (2019). doi:10.1038/s41593-018-0296-9
Nature Neuroscience
Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2929e7ee4be3f4b3dce88ea33ff4c0a
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4
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
Autor: Bradley T. Hyman, Naomi Klickstein, Marc Aurel Busche, George A. Carlson, Tarun V. Kamath, Julia Schiantarelli, Israel Nelken, Susanne Wegmann, Simon Dujardin, Caitlin Commins
Publikováno v: Nature reviews / Neuroscience 22(1), 57-64 (2018). doi:10.1038/s41593-018-0289-8
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer’s disease. However, the underlying neuronal mechanisms are unknown. By employing in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29983d3e8c01d73ef951fcb7d2301504
https://pubmed.ncbi.nlm.nih.gov/30559471
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5
Label-Free Imaging of Cerebral Beta-Amyloidosis with Extended-Focus Optical Coherence Microscopy
Autor: Mitko Dimitrov, Patrick C. Fraering, Bettina M. Wegenast-Braun, Corinne Berclaz, Theo Lasser, Christophe Pache, Martin Villiger, Tristan Bolmont, Arno Bouwens
Publikováno v: The Journal of Neuroscience
The journal of neuroscience 32(42), 14548-14556 (2012). doi:10.1523/JNEUROSCI.0925-12.2012
Journal of Neuroscience; Vol 32
We demonstrate label-free imaging of cerebral β-amyloidosisex vivoand in a living mouse model of Alzheimer's disease using extended-focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3079e34b20b95ca5d6e2de730c302f28
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6
Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits
Autor: Stephanie Schwartz, Markus P. Kummer, Dean W. Hum, Rafael Schwarzenberger, Robert Walczak, Mathieu Dubernet, Sakina Sayah-Jeanne, Michael T. Heneka, Daisy Axt
Publikováno v: Molecular neurobiology 51(2), 661-671 (2014). doi:10.1007/s12035-014-8743-4
Molecular Neurobiology
Mol Neurobiol. 51(2) 661-71 (2014)
ZENODO
Europe PubMed Central
Alzheimer's disease (AD) is a neurodegenerative condition that leads to neuronal death and memory dysfunction. In the past, specific peroxisome proliferator-activated receptor (PPAR)γ-agonists, such as pioglitazone, have been tested with limited suc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b703943fe60c8df808570875635a7a9
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7
Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death
Autor: Henning Scheich, Holger Lison, H.-U. Demuth, Ulrich H. Schröder, B. Seelbinder, Max F. K. Happel, J. Schneeberg, M. Zappe, Klaus G. Reymann, Frank W. Ohl, F. Schneider, Kathrin Baldauf, Jürgen Goldschmidt, S. Kerbstat, Eike Budinger, S. Schilling, R. Rönicke
Publikováno v: Neurobiology of disease 63, 62-73 (2014). doi:10.1016/j.nbd.2013.11.014
Neurobiology of Disease, Vol 63, Iss, Pp 62-73 (2014)
Disruption of neuronal networks in the Alzheimer-afflicted brain is increasingly recognized as a key correlate of cognitive and memory decline in Alzheimer patients. We hypothesized that functional synaptic disconnections within cortical columnar mic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb553c032fa5ac358ddea5076c3c666
https://pubmed.ncbi.nlm.nih.gov/24291517
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8
Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease
Autor: Claudia Abou-Ajram, Melanie Meyer-Luehmann, Sabine Liebscher, Bradley T. Hyman, Joanna F. McCarter, Christian Haass, Mark Hübener, Teresa Bachhuber
Publikováno v: Acta neuropathologica 126(2), 179-188 (2013). doi:10.1007/s00401-013-1137-2
Acta Neuropathologica
Amyloid-β (Aβ) plaque deposition plays a central role in the pathogenesis of Alzheimer’s disease (AD). Post-mortem analysis of plaque development in mouse models of AD revealed that plaques are initially small, but then increase in size and becom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7267f8a3701ced4edaa1c1595171036c
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9
Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice
Autor: Bettina M. Wegenast-Braun, Michael E. Calhoun, Niels J. Rupp, Mathias Jucker, Rebecca Radde
Publikováno v: Neurobiology of aging 32(12), 2324.e1-2324.e6 (2011). doi:10.1016/j.neurobiolaging.2010.08.014
APPPS1 transgenic mice develop amyloid-β 42 (Aβ42)-driven early-onset cerebral β-amyloidosis. Stereological analysis of neocortical neuron number in groups of 2-, 10-, and 17-month-old APPPS1 mice did not reveal any changes compared with wild-type
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53609c8546cce15d875922b2ef4e9c34
https://pub.dzne.de/record/136333
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10
Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI
Autor: Martin Lotze, Stefan J. Teipel, Lary C. Walker, Alexandra Bauer, Anne-Sophie Plath, Evangelia Kaza, Jens Pahnke, Stefan Hadlich, Thomas Brüning, Katja Scheffler, Markus Krohn
Publikováno v: Journal of Alzheimer's disease 23(2), 221-237 (2011). doi:10.3233/JAD-2010-101035
In vivo imaging of amyloid-β (Aβ) load as a biomarker of Alzheimer's disease (AD) would be of considerable clinical relevance for the early diagnosis and monitoring of treatment effects. Here, we investigated automated quantification of in vivo T2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0f75bb728ecdbfd63fe6ee2f820cc0
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