Zobrazeno 1 - 10
of 14
pro vyhledávání: '"genetics [Phosphorylation]"'
Autor:
Yoon A. Kim, Tohid Siddiqui, Jennifer Blaze, Mehmet Ilyas Cosacak, Tristan Winters, Atul Kumar, Ellen Tein, Andrew A. Sproul, Andrew F. Teich, Francesca Bartolini, Schahram Akbarian, Caghan Kizil, Gunnar Hargus, Ismael Santa-Maria
Publikováno v:
Acta neuropathologica 145(1), 29-48 (2023). doi:10.1007/s00401-022-02511-7
Epitranscriptomic regulation adds a layer of post-transcriptional control to brain function during development and adulthood. The identification of RNA-modifying enzymes has opened the possibility of investigating the role epitranscriptomic changes p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc04e0b9f4a77b5dd84b2ebfaa319f4
Autor:
Kathrin Steib, Birgit Heim, Felix von Zweydorf, Elli-Anna Balta, Marius Ueffing, Benjamin M. Häberle, Iris Schäffner, Elisabeth Sock, Julia von Wittgenstein, Elisabeth Kremmer, Dieter Chichung Lie, Marie-Theres Wittmann, Christian Johannes Gloeckner
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific reports 8(1), 16196 (2018). doi:10.1038/s41598-018-34480-x
Scientific Reports
Scientific reports 8(1), 16196 (2018). doi:10.1038/s41598-018-34480-x
The intellectual disability gene, Sox11, encodes for a critical neurodevelopmental transcription factor with functions in precursor survival, neuronal fate determination, migration and morphogenesis. The mechanisms regulating SOX11’s activity remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb253d1add91d4a72df311b82f91e3bf
http://link.springer.com/article/10.1038/s41598-018-34480-x
http://link.springer.com/article/10.1038/s41598-018-34480-x
Autor:
Martin Heni, Annette Feuchtinger, Oana V. Amarie, Annemarie Zimprich, Peter Baumann, Axel Walch, Matthias H. Tschöp, Sonja C. Schriever, Wolfgang Wurst, Andreas Peter, Valerie Gailus-Durner, Martin Hrabě de Angelis, Helmut Fuchs, Stephanie Kullmann, Sabine M. Hölter, Paul T. Pfluger
Publikováno v:
Sci. Rep. 9:19483 (2019)
Scientific reports 9(1), 19483 (2019). doi:10.1038/s41598-019-55527-7
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific reports 9(1), 19483 (2019). doi:10.1038/s41598-019-55527-7
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Dual-specificity phosphatase 8 (Dusp8) acts as physiological inhibitor for the MAPKs Jnk, Erk and p38 which are involved in regulating multiple CNS processes. While Dusp8 expression levels are high in limbic areas such as the hippocampus, the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7e527649b82b72162c2b5cb44529e6
https://doi.org/10.1038/s41598-019-55527-7
https://doi.org/10.1038/s41598-019-55527-7
Autor:
Michael T. Heneka, Lily Keane, Ignazio Antignano, Ai Nagano, Jun Wang, Claude Chelala, Sean-Patrick Riechers, Patrick Neil McCormick, Raphael Zollinger, Paolo Salomoni, Yvonne Biederbick, Anaelle A Dumas, Dario Tejera, Melania Capasso, Frederike Graelmann, Maria Eugenia Bernis, Nina Offermann, Julia Esser, Annett Halle, Jenny Russ
Publikováno v:
J Clin Invest
The journal of clinical investigation 131(1), e132727 (2021). doi:10.1172/JCI132727
The journal of clinical investigation 131(1), e132727 (2021). doi:10.1172/JCI132727
Microglia maintain homeostasis in the brain. However, with age, they become primed and respond more strongly to inflammatory stimuli. We show here that microglia from aged mice had upregulated mTOR complex 1 signaling controlling translation, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05f392a7037319ea89ea4e19e111086
https://pubmed.ncbi.nlm.nih.gov/34651589
https://pubmed.ncbi.nlm.nih.gov/34651589
Autor:
Alan R. Prescott, Graeme Ball, Kyle Fears, Miratul M. K. Muqit, Pentti J. Tienari, Axel Knebel, Johanna Eerola-Rautio, Riccardo Brambilla, Sophie Burel, Lambert Montava-Garriga, Simon Philip Brooks, Odetta Antico, Anu Suomalainen, Ayse Ulusoy, Rachel Hills, Olga Corti, François Mouton-Liger, Eino Palin, Ian G. Ganley, Donato A. Di Monte, Kristin Balk, Jevgenia Tamjar, Thomas G. McWilliams, Laura Smith, François Singh, Stephen B. Dunnett, Risto Pohjolan-Pirhonen, Atul Kumar, Sidi Mohamed Hassoun, Erica Barini, Miko Valori
Publikováno v:
Open Biology
'Open Biology ', vol: 8, pages: 180108-1-180108-18 (2018)
Open biology 8(11), 180108 (2018). doi:10.1098/rsob.180108
Open Biology, Vol 8, Iss 11 (2018)
'Open Biology ', vol: 8, pages: 180108-1-180108-18 (2018)
Open biology 8(11), 180108 (2018). doi:10.1098/rsob.180108
Open Biology, Vol 8, Iss 11 (2018)
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and defined how this dyad orchestrates the elimination of damaged mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baefaa2863884eb308aad3466aa3ab2
http://europepmc.org/articles/PMC6282074
http://europepmc.org/articles/PMC6282074
Autor:
Wolfgang H. Oertel, Bertrand Friguet, Gesine Respondek, Günter U. Höglinger, Matthias Höllerhage, Agathe Tarze, Stefanie Müssner, Mohamed Salama, Christel Depienne, Agnès Rastetter, Anderson de Andrade, Pierre Champy, Elizabeth Sumi Yamada
Publikováno v:
Experimental neurology 253, 113-125 (2014). doi:10.1016/j.expneurol.2013.12.017
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
International audience; Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d266254b13d0c257ddcb9aa3dafadd08
https://doi.org/10.1016/j.expneurol.2013.12.017
https://doi.org/10.1016/j.expneurol.2013.12.017
Autor:
Markus Zweckstetter, Nasrollah Rezaei-Ghaleh, Patrick Wunderlich, Dietmar Rudolf Thal, Jochen Walter, Thomas A. Bayer, Sathish Kumar, Kathrin Stüber, Sandra Theil, Philipp Koch, Oliver Brüstle, Oliver Wirths
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0728842bd419776cad0530d485f5eb0
https://lirias.kuleuven.be/handle/123456789/545197
https://lirias.kuleuven.be/handle/123456789/545197
Autor:
Eckhard Mandelkow, Yipeng Wang
Publikováno v:
Nature reviews / Neuroscience 17(1), 22-35 (2015). doi:10.1038/nrn.2015.1
Nature Reviews Neuroscience
Nature Reviews Neuroscience
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is highly soluble and shows little tendency for aggregation. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea4983b363d30b2b723cdb2ab1f279e
https://pub.dzne.de/record/138272
https://pub.dzne.de/record/138272
Autor:
Giuseppe Viglietto, Alfredo Fusco, Angelo Boccia, Massimo Santoro, Gustavo Baldassarre, Paola Bruni, Gennaro Chiappetta, Francesco Trapasso
Publikováno v:
Scopus-Elsevier
The dual-specificity phosphatase PTEN/MMAC1/TEP1 has recently been identified as the tumor suppressor gene most frequently mutated and/or deleted in human tumors. Germline mutations of PTEN give rise to Cowden Disease (CD), an autosomal dominantly-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34619d2487e600e44105552b7a80de85
https://doi.org/10.1038/sj.onc.1203633
https://doi.org/10.1038/sj.onc.1203633
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22143 (2011)
PLoS ONE
PLoS one 6, e22143 (2011). doi:10.1371/journal.pone.0022143
online available
PLoS ONE
PLoS one 6, e22143 (2011). doi:10.1371/journal.pone.0022143
online available
Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu(2+) was studied using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80187e376dec51f5f8fd8bbc0c18c674
http://europepmc.org/articles/PMC3140484?pdf=render
http://europepmc.org/articles/PMC3140484?pdf=render