Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Autor: Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F. Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Felix Meissner, Rubén Fernández‐Busnadiego, Dieter Edbauer

Publikováno v: Embo Reports, 23(6):e53890. Wiley
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩

International audience; Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f47f8b65554198f2de3cc8266a570e
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78

Alpha-synuclein fragments trigger distinct aggregation pathways

Autor: Wolfgang Wurst, Frits Kamp, Günter U. Höglinger, Valentin Evsyukov, Viktoria Ruf, Tasnim Chakroun, Matthias Höllerhage, Thomas W. Rösler, Andreas Schmidt, Niko-Petteri Nykänen

Publikováno v: Cell Death & Disease
Cell Death Dis. 11:84 (2020)
Cell death & disease 11(2), 84 (2020). doi:10.1038/s41419-020-2285-7
Cell Death and Disease, Vol 11, Iss 2, Pp 1-16 (2020)

Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e5ab334ca0ac21d68406a128f81050
http://europepmc.org/articles/PMC6997403

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

Autor: Wiesje M. van der Flier, Eckart Rüther, Henne Holstege, Johannes Kornhuber, Jens Wiltfang, Charlotte E. Teunissen, Alison Goate, Piotr Lewczuk, Carlos Cruchaga, David Ramonet, Frank Jessen, Markus M. Nöthen, Oliver Peters, Michael T. Heneka, Adam C. Naj, Markus P. Kummer, Christine Herold, Heike Kölsch, R. Heun, Wolfgang Maier, Philip Scheltens, Lutz Frölich, Amy Gerrish, Julius Popp, Vincent Chouraki, Céline Bellenguez, Alzheimer's Disease Neuroimaging Initiative, Dmitriy Drichel, Tim Becker, Lara Buscemi, André Lacour, Monique M.B. Breteler, Stefan Herms, Michael Hüll, Stefanie Heilmann, Alfredo Ramirez, Per Hoffmann, Eva Louwersheimer

Publikováno v: Human Molecular Genetics, Vol. 23, No 24 (2014) pp. 6644-6658
Ramirez, A, van der Flier, W M, Herold, C, Ramonet, D, Heilmann, S, Lewczuk, P, Popp, J, Lacour, A, Drichel, D, Louwersheimer, E, Kummer, M P, Cruchaga, C, Hoffmann, P, Teunissen, C E, Holstege, H, Kornhuber, J, Peters, O, Naj, A C, Chouraki, V, Bellenguez, C, Gerrish, A, Heun, R, Frolich, L, Hull, M, Buscemi, L, Herms, S, Kolsch, H, Scheltens, P, Breteler, M M, Ruther, E, Wiltfang, J, Goate, A, Jessen, F, Maier, W, Heneka, M T, Becker, T & Nothen, M M 2014, ' SUCLG2 identified as both a determinator of CSF Abeta1-42 levels and an attenuator of cognitive decline in Alzheimer's disease ', Human Molecular Genetics, vol. 23, no. 24, pp. 6644-6658 . https://doi.org/10.1093/hmg/ddu372
Human molecular genetics 23(24), 6644-6658 (2014). doi:10.1093/hmg/ddu372
Human Molecular Genetics, 23(24), 6644-6658. Oxford University Press

Cerebrospinal fluid amyloid-beta 1-42 (Aβ1-42) and phosphorylated Tau at position 181 (pTau181) are biomarkers of Alzheimer's disease (AD). We performed an analysis and meta-analysis of genome-wide association study data on Aβ1-42 and pTau181 in AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0346a024e4af22aa36d41fa2a4beaf
http://doc.rero.ch/record/296237/files/ddu372.pdf

Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction

Autor: Stephan Schilling, Michael R. Kreutz, Julia Bär, Michaela Schweizer, Hans-Ulrich Demuth, PingAn Yuanxiang, Gemma Navarro Brugal, Katarzyna M. Grochowska, Arthur Bikbaev, Rajeev Raman, Giriraj Sahu

Publikováno v: EMBO reports
EMBO reports 18(6), 962-981 (2017). doi:10.15252/embr.201643519

Oligomeric amyloid-β (Aβ) 1-42 disrupts synaptic function at an early stage of Alzheimer's disease (AD). Multiple posttranslational modifications of Aβ have been identified, among which N-terminally truncated forms are the most abundant. It is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959dc10d01783fecc14a64114ea1e46

Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells

Autor: Ingo Müller, Bernd Schröder, Regina Fluhrer, Paul Saftig, Anne Kruchen, Reinhard Schneppenheim, Susann Hüttl, Christa Lese Martin, Janna Schneppenheim

Publikováno v: Biochemical and biophysical research communications 451(1), 48-53 (2014). doi:10.1016/j.bbrc.2014.07.051

The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7485d071f2d2fd389276f42f5e4eebd1
https://pubmed.ncbi.nlm.nih.gov/25035924