Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Autor: Meng Li, Thomas Frodl, Lyubomir I. Aftanas, Ben J. Harrison, Frank P. MacMaster, Jair C. Soares, Axel Krug, Benson Mwangi, Christopher G. Davey, Sean N. Hatton, Nynke A. Groenewold, Giovana Zunta-Soares, Angela Carballedo, Bonnie Klimes-Dougan, Katharina Wittfeld, Ilya M. Veer, Philipp G. Sämann, Nils Opel, Ramona Leenings, Yuri Milaneschi, Ian B. Hickie, Dominik Grotegerd, Kathryn R. Cullen, Heather C. Whalley, Henry Völzke, Bernhard T. Baune, Maike Richter, Lianne Schmaal, Andrew M. McIntosh, Jim Lagopoulos, Dan J. Stein, Brenda W.J.H. Penninx, Mon-Ju Wu, Ivan V. Brak, Anouk Schrantee, André Aleman, Georg Woditsch, Janik Goltermann, Elena Pozzi, Kang Sim, Norbert Hosten, Liesbeth Reneman, Hans J. Grabe, Bryon A. Mueller, Klaus Berger, Udo Dannlowski, Martin Walter, Anbupalam Thalamuthu, Tim Hahn, Paul M. Thompson, Igor Nenadic, Laura Nawijn, Evgeniy A. Osipov, Claas Flint, Dick J. Veltman, Tilo Kircher, Henrik Walter, Mathew A. Harris, Marco Hermesdorf, Elena Filimonova, Sandra Van der Auwera, Matthew D. Sacchet, Neda Jahanshad, Ian H. Gotlib

Publikováno v: Molecular psychiatry 26(9), 4839-4852 (2021). doi:10.1038/s41380-020-0774-9
Molecular Psychiatry, 26, 4839-4852. Nature Publishing Group
Molecular Psychiatry, 26(9), 4839-4852. Nature Publishing Group
Molecular psychiatry, 26(9), 4839-4852. Nature Publishing Group
2020, ' Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group ', Molecular Psychiatry, vol. N/A, pp. 1-14 . https://doi.org/10.1038/s41380-020-0774-9
Opel, N, Thalamuthu, A, Milaneschi, Y, Grotegerd, D, Flint, C, Leenings, R, Goltermann, J, Richter, M, Hahn, T, Woditsch, G, Berger, K, Hermesdorf, M, McIntosh, A, Whalley, H C, Harris, M A, MacMaster, F P, Walter, H, Veer, I M, Frodl, T, Carballedo, A, Krug, A, Nenadic, I, Kircher, T, Aleman, A, Groenewold, N A, Stein, D J, Soares, J C, Zunta-Soares, G B, Mwangi, B, Wu, M J, Walter, M, Li, M, Harrison, B J, Davey, C G, Cullen, K R, Klimes-Dougan, B, Mueller, B A, Sämann, P G, Penninx, B, Nawijn, L, Veltman, D J, Aftanas, L, Brak, I V, Filimonova, E A, Osipov, E A, Reneman, L, Schrantee, A, Grabe, H J, Van der Auwera, S, Wittfeld, K, Hosten, N, Völzke, H, Sim, K, Gotlib, I H, Sacchet, M D, Lagopoulos, J, Hatton, S N, Hickie, I, Pozzi, E, Thompson, P M, Jahanshad, N, Schmaal, L, Baune, B T & Dannlowski, U 2021, ' Brain structural abnormalities in obesity : relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group ', Molecular Psychiatry, vol. 26, no. 9, pp. 4839-4852 . https://doi.org/10.1038/s41380-020-0774-9

Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580bb280ea15f755e4cc1444f5dce229
https://doi.org/10.1038/s41380-020-0774-9

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1

Autor: Sebastian Dieckmann, Akim Strohmeyer, Monja Willershäuser, Stefanie F. Maurer, Wolfgang Wurst, Susan Marschall, Martin Hrabe de Angelis, Ralf Kühn, Anna Worthmann, Marceline M. Fuh, Joerg Heeren, Nikolai Köhler, Josch K. Pauling, Martin Klingenspor

Publikováno v: American journal of physiology / Endocrinology and metabolism 322(2), E85-E100 (2022). doi:10.1152/ajpendo.00278.2021
Am. J. Physiol. Endocrinol. Metab. 322, E85-E100 (2022)

Activation of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) upon cold stimulation leads to substantial increase in energy expenditure to defend body temperature. Increases in energy expenditure after a high-caloric food intake, termed die

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681164975b8875e028cf800f04c59a5f
https://pub.dzne.de/record/163261

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study

Autor: Rainer Malik, Nidhi Sofat, Ville Karhunen, Martin Dichgans, Dipender Gill

Publikováno v: Osteoarthritis Cartilage
Osteoarthritis and cartilage 29(3), 365-371 (2021). doi:10.1016/j.joca.2020.12.015
Osteoarthritis and Cartilage

Summary Objective To investigate which cardiometabolic factors underlie clustering of osteoarthritis with cardiovascular disease, and the extent to which these mediate an effect of education. Design Genome-wide association study (GWAS) of osteoarthri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56688138c005ca6ab3dd4678f5a703c9

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Autor: Rozman, Jan, Rathkolb, Birgit, Meehan, Terrence F, Codner, Gemma F, Fiegel, Tanja, Ring, Natalie, Westerberg, Henrik, Greenaway, Simon, Sneddon, Duncan, Morgan, Hugh, Loeffler, Jorik, Stewart, Michelle E, Ramirez-Solis, Ramiro, Mason, Jeremy, Bradley, Allan, Skarnes, William C, Steel, Karen P, Maguire, Simon A, Dench, Joshua, Lafont, David, Vancollie, Valerie E, Pearson, Selina A, Gates, Amy S, Sanderson, Mark, Haselimashhadi, Hamed, Shannon, Carl, Anthony, Lauren F E, Sumowski, Maksymilian T, McLaren, Robbie S B, Doe, Brendan, Wardle-Jones, Hannah, Griffiths, Mark N D, Galli, Antonella, Swiatkowska, Agnieszka, Isherwood, Christopher M, Consortium, IMPC, Speak, Anneliese O, Cambridge, Emma L, Wilson, Heather M, Caetano, Susana S, Maguire, Anna Karin B, Adams, David J, Bottomley, Joanna, Ryder, Ed, Gleeson, Diane, Pouilly, Laurent, Hough, Tertius, Rousseau, Stephane, Auburtin, Aurélie, Reilly, Patrick, Ayadi, Abdel, Selloum, Mohammed, Wood, Joshua A, Clary, Dave, Havel, Peter, Tolentino, Todd, Tolentino, Heather, Mallon, Ann-Marie, Schuchbauer, Mike, Pedroia, Sheryl, Trainor, Amanda, Djan, Esi, Pham, Milton, Huynh, Alison, De Vera, Vincent, Seavitt, John, Gallegos, Juan, Garza, Arturo, Wells, Sara, Mangin, Elise, Senderstrom, Joel, Lazo, Iride, Mowrey, Kate, Bohat, Ritu, Samaco, Rodney, Veeraragavan, Surabi, Beeton, Christine, Kalaga, Sowmya, Kelsey, Lois, Santos, Luis, Vukobradovic, Igor, Berberovic, Zorana, Owen, Celeste, Qu, Dawei, Guo, Ruolin, Newbigging, Susan, Morikawa, Lily, Law, Napoleon, Shang, Xueyuan, Feugas, Patricia, Lelliott, Christopher J, Wang, Yanchun, Eskandarian, Mohammad, Zhu, Yingchun, Penton, Patricia, Laurin, Valerie, Clarke, Shannon, Lan, Qing, Sleep, Gillian, Creighton, Amie, Jacob, Elsa, White, Jacqueline K, Danisment, Ozge, Gertsenstein, Marina, Pereira, Monica, MacMaster, Suzanne, Tondat, Sandra, Carroll, Tracy, Cabezas, Jorge, Hunter, Jane, Clark, Greg, Bubshait, Mohammed, Oestereicher, Manuela A, Sorg, Tania, Miller, David, Sohel, Khondoker, Adissu, Hibret, Ganguly, Milan, Bezginov, Alexandr, Chiani, Francesco, Di Pietro, Chiara, Di Segni, Gianfranco, Ermakova, Olga, Ferrara, Filomena, Champy, Marie-France, Fruscoloni, Paolo, Gambadoro, Aalessia, Gastaldi, Serena, Golini, Elisabetta, La Sala, Gina, Mandillo, Silvia, Marazziti, Daniela, Massimi, Marzia, Matteoni, Rafaele, Orsini, Tiziana, Bower, Lynette R, Pasquini, Miriam, Raspa, Marcello, Rauch, Aline, Rossi, Gianfranco, Rossi, Nicoletta, Putti, Sabrina, Scavizzi, Ferdinando, Tocchini-Valentini, Giuseppe D, Wakana, Shigeharu, Suzuki, Tomohiro, Reynolds, Corey L, Tamura, Masaru, Kaneda, Hideki, Furuse, Tamio, Kobayashi, Kimio, Miura, Ikuo, Yamada, Ikuko, Obata, Yuichi, Yoshiki, Atsushi, Ayabe, Shinya, Chambers, J Nicole, Flenniken, Ann M, Chalupsky, Karel, Seisenberger, Claudia, Bürger, Antje, Beig, Joachim, Kühn, Ralf, Hörlein, Andreas, Schick, Joel, Oritz, Oskar, Giesert, Florian, Graw, Jochen, Murray, Stephen A, Ollert, Markus, Schmidt-Weber, Carsten, Stoeger, Tobias, Önder Yildirim, Ali, Eickelberg, Oliver, Klopstock, Thomas, Busch, Dirk H, Bekeredjian, Raffi, Zimmer, Andreas, Jacobsen, Jules O, Nutter, Lauryl M J, Smedley, Damian, Dickinson, Mary E, Benso, Frank, Morse, Iva, Kim, Hyoung-Chin, Lee, Ho, Cho, Soo Young, Svenson, Karen L, West, David, Tocchini-Valentini, Glauco P, Schütt, Christine, Beaudet, Arthur L, Bosch, Fatima, Braun, Robert B, Dobbie, Michael S, Gao, Xiang, Herault, Yann, Moshiri, Ala, Moore, Bret A, Kent Lloyd, K. C., McKerlie, Colin, Ravindranath, Aakash Chavan, Masuya, Hiroshi, Tanaka, Nobuhiko, Flicek, Paul, Parkinson, Helen E, Sedlacek, Radislav, Seong, Je Kyung, Wang, Chi-Kuang Leo, Moore, Mark, Brown, Steve D, Tschöp, Matthias H, Leuchtenberger, Stefanie, Wurst, Wolfgang, Klingenspor, Martin, Wolf, Eckhard, Beckers, Johannes, Machicao, Fausto, Peter, Andreas, Staiger, Harald, Häring, Hans-Ulrich, Grallert, Harald, Campillos, Monica, Sharma, Sapna, Maier, Holger, Fuchs, Helmut, Gailus-Durner, Valerie, Werner, Thomas, Hrabe de Angelis, Martin, Aguilar-Pimentel, Antonio, Becker, Lore, Treise, Irina, Moreth, Kristin, Garrett, Lillian, Kistler, Martin, Hölter, Sabine M, Zimprich, Annemarie, Marschall, Susan, Amarie, Oana V, Calzada-Wack, Julia, Neff, Frauke, Brachthäuser, Laura, Lengger, Christoph, Stoeger, Claudia, Zapf, Lilly, Willershäuser, Monja, Cho, Yi-Li, da Silva-Buttkus, Patricia, Kraiger, Markus J, Mayer-Kuckuk, Philipp, Gampe, Karen Kristine, Wu, Moya, Conte, Nathalie, Warren, Jonathan, Chen, Chao-Kung, Tudose, Ilinca, Brommage, Robert, Relac, Mike, Matthews, Peter, Cater, Heather L, Natukunda, Helen P, Cleak, James, Teboul, Lydia M, Clementson-Mobbs, Sharon, Szoke-Kovacs, Zsombor, Walling, Alison P, Johnson, Sara J

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature communications, vol 9, iss 1
Rozman, J, Rathkolb, B, Oestereicher, M A, Schütt, C, Ravindranath, A C, Leuchtenberger, S, Sharma, S, Kistler, M, Willershäuser, M, Brommage, R, Meehan, T F, Mason, J, Haselimashhadi, H, Aguilar-Pimentel, A, Becker, L, Treise, I, Moreth, K, Garrett, L, Hölter, S M, Zimprich, A, Marschall, S, Amarie, O V, Calzada-Wack, J, Neff, F, Brachthäuser, L, Lengger, C, Stoeger, C, Zapf, L, Cho, Y L, Da Silva-Buttkus, P, Kraiger, M J, Mayer-Kuckuk, P, Gampe, K K, Wu, M, Conte, N, Warren, J, Chen, C K, Tudose, I, Relac, M, Matthews, P, Cater, H L, Natukunda, H P, Cleak, J, Teboul, L M, Clementson-Mobbs, S, Szoke-Kovacs, Z, Walling, A P, Johnson, S J, Codner, G F, Fiegel, T, Ring, N, Westerberg, H, Greenaway, S, Sneddon, D, Morgan, H, Loeffler, J, Stewart, M E, Ramirez-Solis, R, Bradley, A, Skarnes, W C, Steel, K P, Maguire, S A, Dench, J, Lafont, D, Vancollie, V E, Pearson, S A, Gates, A S, Sanderson, M, Shannon, C, Anthony, L F E, Sumowski, M T, McLaren, R S B, Doe, B, Wardle-Jones, H, Griffiths, M N D, Galli, A, Swiatkowska, A, Isherwood, C M, Speak, A O, Cambridge, E L, Wilson, H M, Caetano, S S, Maguire, A K B, Adams, D J, Bottomley, J, Ryder, E, Gleeson, D, Pouilly, L, Rousseau, S, Auburtin, A, Reilly, P, Ayadi, A, Selloum, M, Wood, J A, Clary, D, Havel, P, Tolentino, T, Tolentino, H, Schuchbauer, M, Pedroia, S, Trainor, A, Djan, E, Pham, M, Huynh, A, De Vera, V, Seavitt, J, Gallegos, J, Garza, A, Mangin, E, Senderstrom, J, Lazo, I, Mowrey, K, Bohat, R, Samaco, R, Veeraragavan, S, Beeton, C, Kalaga, S, Kelsey, L, Vukobradovic, I, Berberovic, Z, Owen, C, Qu, D, Guo, R, Newbigging, S, Morikawa, L, Law, N, Shang, X, Feugas, P, Wang, Y, Eskandarian, M, Zhu, Y, Penton, P, Laurin, V, Clarke, S, Lan, Q, Sleep, G, Creighton, A, Jacob, E, Danisment, O, Gertsenstein, M, Pereira, M, MacMaster, S, Tondat, S, Carroll, T, Cabezas, J, Hunter, J, Clark, G, Bubshait, M, Miller, D, Sohel, K, Adissu, H, Ganguly, M, Bezginov, A, Chiani, F, Di Pietro, C, Di Segni, G, Ermakova, O, Ferrara, F, Fruscoloni, P, Gambadoro, A, Gastaldi, S, Golini, E, La Sala, G, Mandillo, S, Marazziti, D, Massimi, M, Matteoni, R, Orsini, T, Pasquini, M, Raspa, M, Rauch, A, Rossi, G, Rossi, N, Putti, S, Scavizzi, F, Tocchini-Valentini, G D, Wakana, S, Suzuki, T, Tamura, M, Kaneda, H, Furuse, T, Kobayashi, K, Miura, I, Yamada, I, Obata, Y, Yoshiki, A, Ayabe, S, Chambers, J N, Chalupsky, K, Seisenberger, C, Bürger, A, Beig, J, Kühn, R, Hörlein, A, Schick, J, Oritz, O, Giesert, F, Graw, J, Ollert, M, Schmidt-Weber, C, Stoeger, T, Önder Yildirim, A, Eickelberg, O, Klopstock, T, Busch, D H, Bekeredjian, R, Zimmer, A, Jacobsen, J O, Smedley, D, Dickinson, M E, Benso, F, Morse, I, Kim, H C, Lee, H, Cho, S Y, Hough, T, Mallon, A M, Wells, S, Santos, L, Lelliott, C J, White, J K, Sorg, T, Champy, M F, Bower, L R, Reynolds, C L, Flenniken, A M, Murray, S A, Nutter, L M J, Svenson, K L, West, D, Tocchini-Valentini, G P, Beaudet, A L, Bosch, F, Braun, R B, Dobbie, M S, Gao, X, Herault, Y, Moshiri, A, Moore, B A, Kent Lloyd, K C, McKerlie, C, Masuya, H, Tanaka, N, Flicek, P, Parkinson, H E, Sedlacek, R, Seong, J K, Wang, C K L, Moore, M, Brown, S D, Tschöp, M H, Wurst, W, Klingenspor, M, Wolf, E, Beckers, J, MacHicao, F, Peter, A, Staiger, H, Häring, H U, Grallert, H, Campillos, M, Maier, H, Fuchs, H, Gailus-Durner, V, Werner, T & De Angelis, M H 2018, ' Identification of genetic elements in metabolism by high-throughput mouse phenotyping ', Nature Communications, vol. 9, 288 . https://doi.org/10.1038/s41467-017-01995-2
Nature Communications 9(1), 288 (2018). doi:10.1038/s41467-017-01995-2
Nat. Commun. 9:288 (2018)

Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b0e532914292040e57c2e66d31b14e
http://europepmc.org/articles/PMC5773596

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Autor: P. Eline Slagboom, Massimo Mangino, David J. Porteous, Karin Leander, Nancy L. Heard-Costa, Sharon L.R. Kardia, Jennifer Bragg, Ken K. Ong, Igor Rudan, Blair H. Smith, Mark A. Sarzynski, Torben Hansen, James F. Wilson, Weihua Zhang, Zoltán Kutalik, Karl Gertow, Yii-Der Ida Chen, Daniele Cusi, Lu Qi, Nicholas G. Martin, Peter Vollenweider, Thomas W. Winkler, Graciela E. Delgado, Thorkild I. A. Sørensen, André G. Uitterlinden, J. Wouter Jukema, Rajesh Rawal, Dena G. Hernandez, Amy J. Swift, Naveed Sattar, Ruth J. F. Loos, George Dedoussis, Ani Manichaikul, Henrik Vestergaard, Jian'an Luan, Luting Xue, Charles Kooperberg, Rona J. Strawbridge, John-Olov Jansson, Jian Gong, Martina Müller-Nurasyid, L. Adrienne Cupples, Frida Renström, Stephan J. L. Bakker, Ivana Kolcic, Mathias Gorski, Tamara B. Harris, Sandosh Padmanabhan, Stephanie A. Bien, Arthur W. Musk, Cristina Menni, Steve Buyske, Anubha Mahajan, Claudia Schurmann, John Blangero, Natalia Pervjakova, Inês Barroso, Kristin L. Young, Momoko Horikoshi, Robert A. Scott, Ozren Polasek, Shafqat Ahmad, Jeremiah Perez, Stella Trompet, Claude Bouchard, Claudia Langenberg, Paul M. Ridker, Tuomas O. Kilpeläinen, Oddgeir L. Holmen, Tarunveer S. Ahluwalia, Alan F. Wright, Ulf de Faire, Cecilia M. Lindgren, Misa Graff, Jie Huang, Liesbeth Vandenput, Marcel Bruinenberg, Luigi Ferrucci, Johanne Marie Justesen, Audrey Y. Chu, Melanie Waldenberger, Karen L. Mohlke, Ching-Ti Liu, Barbara Thorand, Joseph Hung, Pim van der Harst, Colin A. McKenzie, Sailaja Vedantam, Gitta H. Lubke, Bruna Gigante, Göran Hallmans, Sara Lupoli, Anja Ludolph-Donislawski, Michael Boehnke, Treva Rice, Lori L. Bonnycastle, Daniele Braga, Mika Kähönen, Joel Eriksson, Gonçalo R. Abecasis, Joseph M. Wu, Niels Grarup, Ilja M. Nolte, Jonathan Marchini, Georg Homuth, Pamela A. F. Madden, John Beilby, Andrew D. Johnson, Nanette R. Lee, Caroline Hayward, Unhee Lim, Bamidele O. Tayo, Peter S. Chines, Lynda M. Rose, Amélie Bonnefond, Elena Tremoli, Serena Sanna, David P. Strachan, Barbara McKnight, Narisu Narisu, Anton J. M. de Craen, David R. Weir, Albertine J. Oldehinkel, Jessica Tyrrell, Beverley Balkau, Kirsti Kvaløy, Marie-Claude Vohl, Jennifer A. Smith, Rainer Rauramaa, Andrew C. Heath, Erwin P. Bottinger, Andrew Wong, Günther Silbernagel, Mattias Lorentzon, Philippe Froguel, Uzma Afzal, Tanja B. Grammer, Dabeeru C. Rao, Charlotta Pisinger, Nicola Glorioso, Najaf Amin, Andrew P. Morris, Tanguy Corre, Alan James, Julius S. Ngwa, Jennifer E. Huffman, Gudny Eiriksdottir, Maija Hassinen, Lenore J. Launer, Marit E. Jørgensen, Dorret I. Boomsma, Harry Campbell, Scott Coggeshall, Timothy M. Frayling, Konstantin Strauch, Johanna Kuusisto, David Hadley, Penny Gordon-Larsen, Xuan Deng, Dorothée Thuillier, Albert V. Smith, Jaakko Tuomilehto, Harald Grallert, Lynne J. Hocking, Dan Mellström, M. Carola Zillikens, Lars Lind, Hester M. den Ruijter, Gemma Cadby, Joanne E. Curran, Richard N. Bergman, David J. Stott, Matthias Olden, Veronique Vitart, Robert Luben, Cinzia Sarti, Gert J. de Borst, Lyle J. Palmer, Sven Bergmann, Alexander Teumer, John D. Eicher, Marcus E. Kleber, Marie Loh, Genovefa Kolovou, Iris M. Heid, Gonneke Willemsen, Marie Neergaard Harder, David J. Hunter, Stefania Bandinelli, Francis S. Collins, Hans J. Grabe, Virginia Fisher, John Whitfield, Leo-Pekka Lyytikäinen, Salome Scholtens, Tamuno Alfred, Richard S. Cooper, Jouke-Jan Hottenga, Martina Chittani, Jan A. Staessen, Bernhard K. Krämer, Markku Laakso, Min A. Jhun, Marjo-Riitta Järvelin, Saima Afaq, Rita P. S. Middelberg, Jing Hua Zhao, Toshiko Tanaka, Kent D. Taylor, Rudi G. J. Westendorp, Panagiotis Deloukas, Nina Hutri-Kähönen, Reiner Biffar, Krista Fischer, Leena Kinnunen, Diana Kuh, Jaspal S. Kooner, Caroline S. Fox, Harold Snieder, Pau Navarro, Stéphane Lobbens, Tao Huang, Vilmundur Gudnason, Jacqueline M. Vink, Terrence Forrester, Kari E. North, Annette Peters, Mika Kivimäki, David Schlessinger, Ian Ford, Kristian Hveem, Christopher A. Haiman, Lucia A. Hindorff, Oluf Pedersen, Ingrid B. Borecki, Bruce H. R. Wolffenbuttel, Nicholas J. Wareham, Cornelia M. van Duijn, Lawrence F. Bielak, Loic Le Marchand, Linda S. Adair, Tõnu Esko, Anne U. Jackson, Ying Wu, Eco J. C. de Geus, Jana V. van Vliet-Ostaptchouk, Louis Pérusse, Peter J. van der Most, Ulrike Peters, Magnus Karlsson, Anders Hamsten, Anne E. Justice, Alena Stančáková, Henning Tiemeier, Eric Boerwinkle, Catharina A. Hartman, Claes Ohlsson, Grant W. Montgomery, Elise Lim, Traci M. Bartz, Erik Ingelsson, Martina E. Zimmermann, Laura J. Rasmussen-Torvik, Terho Lehtimäki, Heikki A. Koistinen, Pirjo Komulainen, Damiano Baldassarre, Marten A. Siemelink, Niek Verweij, Gerard Pasterkamp, Markus Juonala, Wei Zhao, Andres Metspalu, Sander W. van der Laan, Tuomo Rankinen, Timo A. Lakka, Yun Ju Sung, Heather M. Stringham, Bruce M. Psaty, Niha Zubair, Stavroula Kanoni, Saskia Haitjema, Bengt Sennblad, Llilda Barata, Morris A. Swertz, Mary F. Feitosa, Tim D. Spector, Paul W. Franks, Qibin Qi, Francesco Cucca, Allan Linneberg, Reija Männikkö, Jonathan Marten, Olli T. Raitakari, Mark I. McCarthy, Joel N. Hirschhorn, Winfried März, Sarah H. Wild, Meena Kumari, Nese Direk, Patricia A. Peyser, Jessica D. Faul, John C. Chambers, Nicholas D. Hastie, Mette Hollensted, Jacek Czajkowski, Daniel I. Chasman, Matthias Nauck, Gérard Waeber, Brendan M. Buckley, Kai Savonen, Judith M. Vonk, Carsten A. Böger, Loic Yengo, Anna Eriksson, Henry Völzke, Pedro Marques-Vidal

Publikováno v: Nature communications, vol. 8, pp. 14977
Nature Communications, 8:14977. Nature Publishing Group
Nature communications 8 (2017). doi:10.1038/ncomms14977
info:cnr-pdr/source/autori:Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha; Renstrom, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F.; Bonnefond, Amelie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Harder, Marie Neergaard; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E.; Jackson, Anne U.; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E.; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikainen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P. S.; Mueller-Nurasyid, Martina; Navarro, Pau; Perusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A.; Stancakova, Alena; Strawbridge, Rona J.; Stringham, Heather M.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W.; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Vedantam, Sailaja L.; Verweij, Niek; Vink, Jacqueline M.; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Zhao, Jing Hua; Zimmermann, Martina E.; Zubair, Niha; Abecasis, Goncalo R.; Adair, Linda S.; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J. L.; Bartz, Traci M.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M.; Buyske, Steve; Campbell, Harry; Chambers, John C.; Collins, Francis S.; Curran, Joanne E.; de Borst, Gert J.; de Craen, Anton J. M.; de Geus, Eco J. C.; Dedoussis, George; Delgado, Graciela E.; den Ruijter, Hester M.; Eiriksdottir, Gudny; Eriksson, Anna L.; Esko, Tonu; Faul, Jessica D.; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; Haitjema, Saskia; Hallmans, Goran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas D.; Heath, Andrew C.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Hollensted, Mette; Holmen, Oddgeir L.; Homuth, Georg; Hottenga, Jouke Jan; Huang, Jie; Hung, Joseph; Hutri-Kahonen, Nina; Ingelsson, Erik; James, Alan L.; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A.; Jorgensen, Marit E.; Juonala, Markus; Kahonen, Mika; Karlsson, Magnus; Koistinen, Heikki A.; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Kramer, Bernhard K.; Kuusisto, Johanna; Kvaloy, Kirsti; Lakka, Timo A.; Langenberg, Claudia; Launer, Lenore J.; Leander, Karin; Lee, Nanette R.; Lind, Lars; Lindgren, Cecilia M.; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A. F.; Mannikko, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; McKenzie, Colin A.; McKnight, Barbara; Mellstrom, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, A. W. (Bill); Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Peyser, Patricia A.; Pisinger, Charlotta; Porteous, David J.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Rice, Treva; Ridker, Paul M.; Rose, Lynda M.; Bien, Stephanie A.; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A.; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A.; Sennblad, Bengt; Siemelink, Marten A.; Silbernagel, Gunther; Slagboom, P. Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J.; Swertz, Morris A.; Swift, Amy J.; Taylor, Kent D.; Tayo, Bamidele O.; Thorand, Barbara; Thuillier, Dorothee; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Vandenput, Liesbeth; Vohl, Marie-Claude; Volzke, Henry; Vonk, Judith M.; Waeber, Gerard; Waldenberger, Melanie; Westendorp, R. G. J.; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Wright, Alan F.; Zhao, Wei; Zillikens, M. Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Boger, Carsten A.; Boomsma, Dorret I.; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I.; Chen, Yii-Der Ida; Chines, Peter S.; Cooper, Richard S.; Cucca, Francesco; Cusi, Daniele; de Faire, Ulf; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans-Jorgen; Gudnason, Vilmundur; Haiman, Christopher A.; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D.; Jukema, Wouter; Kardia, Sharon L. R.; Kivimaki, Mika; Kooner, Jaspal S.; Kuh, Diana; Laakso, Markku; Lehtimaki, Terho; Le Marchand, Loic; Marz, Winfried; McCarthy, Mark I.; Metspalu, Andres; Morris, Andrew P.; Ohlsson, Claes; Palmer, Lyle J.; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Smith, Blair H.; Sorensen, Thorkild I. A.; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; Van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J.; Weir, David R.; Whitfield, John B.; Wilson, James F.; Tyrrell, Jessica; Frayling, Timothy M.; Barroso, Ines; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S.; Hirschhorn, Joel N.; Hunter, David J.; Spector, Tim D.; Strachan, David P.; van Duijn, Cornelia M.; Heid, Iris M.; Mohlke, Karen L.; Marchini, Jonathan; Loos, Ruth J. F.; Kilpelainen, Tuomas O.; Liu, Ching-Ti; Borecki, Ingrid B.; North, Kari E.; Cupples, L. Adrienne/titolo:Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits/doi:10.1038%2Fncomms14977/rivista:Nature communications/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, S W, Van Der Most, P J, Van Vliet-ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, De Borst, G J, De Craen, A J M, De Geus, E J C, Dedoussis, G, Delgado, G E, Den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-kähönen, N, Ingelsson, E, James, A L, Jansson, J, Jarvelin, M, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-vidal, P, Martin, N G, Mckenzie, C A, Mcknight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, Mccarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, Van Der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, Van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8 . https://doi.org/10.1038/ncomms14977
Nature Communications, 8
Nature Communications
Nature Communications [E], 8. Nature Publishing Group
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, S W, Van Der Most, P J, Van Vliet-ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, De Borst, G J, De Craen, A J M, De Geus, E J C, Dedoussis, G, Delgado, G E, Den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-kähönen, N, Ingelsson, E, James, A L, Jansson, J, Jarvelin, M, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-vidal, P, Martin, N G, Mckenzie, C A, Mcknight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, Mccarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, Van Der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, Van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977 . https://doi.org/10.1038/ncomms14977
Nature Communications 8(1), 14977 (2017). doi:10.1038/ncomms14977
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K L, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-Costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J C, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg-Gresham, J L, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S W, van der Most, P J, van Vliet-Ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E P, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, de Borst, G J, De Craen, A J M, de Geus, E J C, Dedoussis, G, Delgado, G E, den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L A, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, A L, Jansson, J-O, Jarvelin, M R, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-Vidal, P, Martin, N G, Mckenzie, C A, McKnight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A B, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-Torvik, L J, Rawal, R, Rice, T K, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y-D, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-Larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, McCarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J L, Loos, R J F, Kilpeläinen, T O, Liu, C-T, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977 . https://doi.org/10.1038/ncomms14977
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K L, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-Costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg-Gresham, J L, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S W, van der Most, P J, van Vliet-Ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, de Borst, G J, De Craen, A J M, de Geus, E J C, Dedoussis, G, Delgado, G E, den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D G, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, A L, Jansson, J-O, Jarvelin, M-R, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-Vidal, P M, Martin, N G, McKenzie, C A, McKnight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A B, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-Torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y-D, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-Larsen, P, Grabe, H-J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, McCarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C-T, Borecki, I B, North, K E, Cupples, L A & Hottenga, J J 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977, pp. 14977 . https://doi.org/10.1038/ncomms14977
8:14977
Nat. Commun. 8:14977 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
NATURE COMMUNICATIONS

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2beaf8ea3de784ca0d01a3dcf8ab9d22
https://doi.org/10.1038/ncomms14977