Zobrazeno 1 - 10
of 15
pro vyhledávání: '"genetics [Neuronal Plasticity]"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications 12(1), 3892 (2021). doi:10.1038/s41467-021-23993-1
Nature Communications
Nature Communications 12(1), 3892 (2021). doi:10.1038/s41467-021-23993-1
Nature Communications
The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using geno
Publikováno v:
Progress in neuro-psychopharmacology & biological psychiatry 119, 110614-(2022). doi:10.1016/j.pnpbp.2022.110614
Recent genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms affecting depressive disorders. GWAS results support the heterogeneity of depression as a disorder affected by a large number of genetic variants w
Autor:
Georg Köhr, Dušica Briševac, Dan Du, Ralf Scholz, Mohammad Nael Elagabani, Hans-Christian Kornau
Publikováno v:
Journal of neurochemistry 157(3), 666-683 (2021). doi:10.1111/jnc.15230
Journal of Neurochemistry : official journal of the International Society for Neurochemistry
Journal of Neurochemistry : official journal of the International Society for Neurochemistry
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, results from silencing of the fragile X mental retardation gene 1 (FMR1). The analyses of FXS patients’ brain autopsies revealed an increased density of immature
Autor:
Prateep Beed, Saikat Ray, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier, Aarti Swaminathan, Noam Nitzan, Jörg Breustedt, Liora Las, Michael Brecht, Dietmar Schmitz
Publikováno v:
Scientific Reports
Scientific reports 10(1), 16557 (2020). doi:10.1038/s41598-020-73547-6
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific reports 10(1), 16557 (2020). doi:10.1038/s41598-020-73547-6
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Synaptic transmission and plasticity in the hippocampus are integral factors in learning and memory. While there has been intense investigation of these critical mechanisms in the brain of rodents, we lack a broader understanding of the generality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ba977b717ed3f1be7c89c11513a3a1
http://edoc.mdc-berlin.de/19430/1/19430oa.pdf
http://edoc.mdc-berlin.de/19430/1/19430oa.pdf
Autor:
Ivan Lazarevich, Maiya A. Rozhnova, Sergey V. Stasenko, Alexander Dityatev, Victor B. Kazantsev, Evgeniya V. Pankratova
Publikováno v:
PLoS ONE
PLOS ONE 15(1), e0227917 (2020). doi:10.1371/journal.pone.0227917
PLoS ONE, Vol 15, Iss 1, p e0227917 (2020)
PLOS ONE 15(1), e0227917 (2020). doi:10.1371/journal.pone.0227917
PLoS ONE, Vol 15, Iss 1, p e0227917 (2020)
Experimental studies highlight the important role of the extracellular matrix (ECM) in the regulation of neuronal excitability and synaptic connectivity in the nervous system. In its turn, the neural ECM is formed in an activity-dependent manner. Its
Autor:
Andreas Dahl, Prabesh Bhattarai, Andreas Petzold, Susanne Reinhardt, Caghan Kizil, Mehmet Ilyas Cosacak, Yixin Zhang
Publikováno v:
Cell reports 27(4), 1307-1318.e3 (2019). doi:10.1016/j.celrep.2019.03.090
The neural stem cell (NSC) reservoir can be harnessed for stem cell-based regenerative therapies. Zebrafish remarkably regenerate their brain by inducing NSC plasticity in a Amyloid-β-42 (Aβ42)-induced experimental Alzheimer's disease (AD) model. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0697dcfe5d0d0254c22de0ce316e27
https://pub.dzne.de/record/140652
https://pub.dzne.de/record/140652
Autor:
Andrea Schmitt, Nelson Rebola, Susanne Burkhardt, Christophe Mulle, Eva Benito, Ivana Delalle, Roberto Carlos Agis-Balboa, Alexander Jatzko, Gaurav Jain, Patricia A. Zunszain, Sanaz Bahari-Javan, Paulo S. Pinheiro, Julius C. Pape, Markus Dettenhofer, Peter Falkai, Michael Gertig, Farahnaz Sananbenesi, Cemil Kerimoglu, Elisabeth B. Binder, Andre Fischer
Publikováno v:
Agís-Balboa, R C, Pinhero, P, Rebola, N, Kerimoglu, C, Benito, E, Gertig, M, Bahari-Javan, S, Jain, G, Burkhardt, S, Delalle, I, Jatzko, A, Dettenhofer, M, Zunszain, P A, Schmitt, A, Falkai, P, Pape, J C, Binder, E B, Mulle, C, Fischer, A & Sananbenesi, F 2017, ' Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia ', The EMBO journal, vol. 36, no. 19, pp. 2815-2828 . https://doi.org/10.15252/embj.201796821
The EMBO journal 36(19), 2815-2828 (2017). doi:10.15252/embj.201796821
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
EMBO JOURNAL
The EMBO Journal
The EMBO journal 36(19), 2815-2828 (2017). doi:10.15252/embj.201796821
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
EMBO JOURNAL
The EMBO Journal
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c13c908d6e0f860de3484a7771db35
https://kclpure.kcl.ac.uk/ws/files/80023520/Formin_2_links_neuropsychiatric_AGILS_BALBOA_Publishedonline2August2017_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/80023520/Formin_2_links_neuropsychiatric_AGILS_BALBOA_Publishedonline2August2017_GOLD_VoR_CC_BY_.pdf
Autor:
Alexandru Rusu, Ling Zhang, Jakob von Engelhardt, Paul Farrow, Anton Schulmann, Konstantin Khodosevich, Eric Jacobi, Rolf Sprengel, Hannah Monyer
Publikováno v:
Neuron 83(3), 601-615 (2014). doi:10.1016/j.neuron.2014.07.004
Neuron
Neuron
Summary Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 i
Autor:
Frauke van Bebber, Vincenzo Capece, Eva Benito, Magali Hennion, Ramon O. Vidal, Sanaz Bahari Javan, Orr Shomroni, Stefan Bonn, Christian Haass, Susanne Burkhardt, Ashish Rajput, Tonatiuh Pena Centeno, Rashi Halder, Julio C. Garcia Vizcaino, Andre Fischer, Magdalena Navarro Sala, Raza-Ur Rahman, Anna-Lena Schuetz, Bettina Schmid
Publikováno v:
Nature reviews / Neuroscience 19(1), 102-110 (2016). doi:10.1038/nn.4194
The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e9af6097307419096d12871ff24691
https://pub.dzne.de/record/138297
https://pub.dzne.de/record/138297
Autor:
Becker A, Jagla W, Steffen Rossner, von Hörsten S, Raber Ka, Bäuscher C, S. Schilling, Sedlmeier R, Alexander P. Osmand, H.-U. Demuth, Holger Cynis, Alexandru A, Graubner S, Kohlmann S, Hartlage-Rübsamen M, Petrasch-Parwez E, Raik Rönicke, Klaus G. Reymann, Waniek A
Publikováno v:
The journal of neuroscience 31(36), 12790-12801 (2011). doi:10.1523/JNEUROSCI.1794-11.2011
Posttranslational amyloid-β (Aβ) modification is considered to play an important role in Alzheimer's disease (AD) etiology. An N-terminally modified Aβ species, pyroglutamate-amyloid-β (pE3–Aβ), has been described as a major constituent of Aβ