Výsledky vyhledávání - "genetics [Microtubules]"

The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure

Autor: Adriana Savastano, Adam G. Hendricks, Markus Zweckstetter, Alisa Cario, Z. Liu, Christopher L. Berger, Neil B. Wood, Michael J. Previs

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 119(7), e2114215119 (2022). doi:10.1073/pnas.2114215119

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15064374896c20d2c164af1747b0ba20

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Tea2p Is a Kinesin-like Protein Required to Generate Polarized Growth in Fission Yeast

Autor: Lauren Aveline, Juan Mata, Heidi Browning, J. Richard McIntosh, Jacqueline Hayles, Paul Nurse

Publikováno v: The Journal of Cell Biology

Cytoplasmic microtubules are critical for establishing and maintaining cell shape and polarity. Our investigations of kinesin-like proteins (klps) and morphological mutants in the fission yeast Schizosaccharomyces pombe have identified a kinesin-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29ff1d0807ec9642316f112e3403928
https://doi.org/10.1083/jcb.151.1.15

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DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis

Autor: Joel N. Meyer, Michael O. Hengartner, Simona Maida, Xue Zheng, Markus G. Manz, Carlo-Alberto Rossi, Daniele Bano, Moyin Shi, Jason M. Kinchen, Sérgio Morgado Pinto, Steffen Boettcher, Deni Subasic, Youjin Teo, Ataman Sendoel, Lilli Stergiou

Publikováno v: Nature cell biology 16(8), 812-820 (2014). doi:10.1038/ncb3010
Nat Cell Biol
Nature cell biology

Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1. The signalling cascade linking microtubule disruption to MCL1 degradation remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2626d3ab16720f8f2742ab80da1bef7
https://pub.dzne.de/record/137485

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Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model

Autor: Petra Füger, Kathrin N. Karle, Doychin T. Stanchev, Carola D. Schneider, Matthias Flötenmeyer, Jeannine V. Kern, Vrinda Sreekumar, Katharina J. Daub, Vera K. Siegert, Rebecca Schüle, Tobias M. Rasse, Ludger Schöls, Heinz Schwarz

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 8, Iss 11, p e1003066 (2012)
PLoS Genetics 8(11), e1003066 (2012). doi:10.1371/journal.pgen.1003066

Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities. We have generated a Drosophila model for HSP type 10 (SPG10), caused by mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e98242ad78e8afd6297ab0e2066f6ad
https://pubmed.ncbi.nlm.nih.gov/23209432

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Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential

Autor: Timm, T., von Kries, J., Li, X., Zempel, H., Mandelkow, E.

Publikováno v: The journal of biological chemistry, 286(48): 41711–41722
The journal of biological chemistry 286(48), 41711-41722 (2011). doi:10.1074/jbc.M111.257865
Journal of Biological Chemistry

BACKGROUND: Deregulation of the protein kinase MARK has been linked to Alzheimer disease. - RESULTS: Mark-specific inhibitors and a biosensor are identified. - CONCLUSION: The inhibitors and the biosensor are tools to provide new insights into the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::81090cd9da31aad357a3ef6cd9421d44
https://repository.publisso.de/resource/frl:6406519

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Dynamic recruitment of Cdc2 to specific microtubule structures during mitosis

Autor: Jean-Pierre David, Pavla Binarová, László Bögre, Magdalena Weingartner, Erwin Heberle-Bors, Denisa Drykova, John H. Doonan, Alois Schweighofer

Publikováno v: Plant Cell, 13 (8)

A-type cyclin-dependent kinases (CDKs), also known as cdc2, are central to the orderly progression of the cell cycle. We made a functional Green Fluorescent Protein (GFP) fusion with CDK-A (Cdc2-GFP) and followed its subcellular localization during t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ae68b18a5ac7e16ad907729d60e185
https://repository.royalholloway.ac.uk/items/62ed69d5-8495-faa8-19c5-978d3ff7534f/5/

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