Zobrazeno 1 - 10
of 31
pro vyhledávání: '"genetics [Lysine]"'
Autor:
Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban
Publikováno v:
Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444ec66987556cb4c7f6b85293f7171
https://doi.org/10.1038/s41598-019-50927-1
https://doi.org/10.1038/s41598-019-50927-1
Autor:
Dorothee Dormann, Maria-Sol Cima-Omori, Tina Ukmar-Godec, Saskia Hutten, Eckhard Mandelkow, Jacek Biernat, Nasrollah Rezaei-Ghaleh, Matthew P. Grieshop, Johannes Söding, Markus Zweckstetter
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications 10(1), 2909 (2019). doi:10.1038/s41467-019-10792-y
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications 10(1), 2909 (2019). doi:10.1038/s41467-019-10792-y
Cells form and use biomolecular condensates to execute biochemical reactions. The molecular properties of non-membrane-bound condensates are directly connected to the amino acid content of disordered protein regions. Lysine plays an important role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b801486d8ee6de8474773052015ac0
https://pubmed.ncbi.nlm.nih.gov/31266957
https://pubmed.ncbi.nlm.nih.gov/31266957
Autor:
Gael Cagnone, Siddhant U. Jain, Warren A. Cheung, Jacek Majewski, Simon Papillon-Cavanagh, Shriya Deshmukh, Hamid Nikbakht, Jad I. Belle, Haifen Chen, Damien Faury, Benjamin Ellezam, Peter W. Lewis, Carol C.L. Chen, Nicolas De Jay, Abdulshakour Mohammadnia, Bo Hu, Melissa K. McConechy, Brian Krug, Dylan M. Marchione, Claudia L. Kleinman, Michele Zeinieh, Chao Lu, Ashot S. Harutyunyan, Tomi Pastinen, Leonie G. Mikael, Benjamin A. Garcia, Manav Pathania, Alexander G. Weil, Nada Jabado, Rui Li, Alexandre Montpetit, Denise Bechet, Paolo Salomoni
Publikováno v:
Nature Communications
Nature Communications 10(1), 1262 (2019). doi:10.1038/s41467-019-09140-x
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications 10(1), 1262 (2019). doi:10.1038/s41467-019-09140-x
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8009a4766e296bb95581ac15a67e41
https://pubmed.ncbi.nlm.nih.gov/30890717
https://pubmed.ncbi.nlm.nih.gov/30890717
Autor:
Sven Geisler, Emiko Miura, Takafumi Hasegawa, Masashi Aoki, Masashi Konno, Mitsunori Fukuda, Atsushi Takeda, Nobuyuki Tanaka, Akio Kikuchi, Tadashi Anan, Toru Baba, Koichi Wakabayashi, Mitsuyoshi Nakao, Naoto Sugeno, Ryuji Oshima
Publikováno v:
The journal of biological chemistry 289(26), 18137-18151 (2014). doi:10.1074/jbc.M113.529461
α-Synuclein (aS) is a major constituent of Lewy bodies, which are not only a pathological marker for Parkinson disease but also a trigger for neurodegeneration. Cumulative evidence suggests that aS spreads from cell to cell and thereby propagates ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f3d074b9cdb1cdffae904559c3d761
https://pubmed.ncbi.nlm.nih.gov/24831002
https://pubmed.ncbi.nlm.nih.gov/24831002
Autor:
Law, Bernard M. H., Spain, Victoria A., Leinster, Veronica H. L., Chia, Ruth, Beilina, Alexandra, Cho, Hyun J., Taymans, Jean-Marc, Urban, Mary K., Sancho, Rosa M., Blanca Ramírez, Marian, Biskup, Saskia, Baekelandt, Veerle, Cai, Huaibin, Cookson, Mark R., Berwick, Daniel C., Harvey, Kirsten
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry 289(2), 895-908 (2013). doi:10.1074/jbc.M113.507913
The journal of biological chemistry 289(2), 895-908 (2013). doi:10.1074/jbc.M113.507913
Background: Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause Parkinson disease. Results: LRRK2 binds directly to three β-tubulin isoforms at the luminal face of microtubules and suppresses α-tubulin acetylation. Interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5e43307ee30a1a341d03175088b47a73
http://oro.open.ac.uk/44279/1/__userdata_documents2_rfw62_Desktop_895.full.pdf
http://oro.open.ac.uk/44279/1/__userdata_documents2_rfw62_Desktop_895.full.pdf
Publikováno v:
Gene Therapy Weekly; 10/17/2023, p948-948, 1p
Publikováno v:
Gene Therapy Weekly; 10/6/2023, p1150-1150, 1p
Publikováno v:
Cytogenetic and Genome Research
Cytogenetic and Genome Research, Karger, 2002, 99 (1-4), pp.66--74. ⟨10.1159/000071576⟩
Cytogenetic and Genome Research, Karger, 2002, 99 (1-4), pp.66--74. ⟨10.1159/000071576⟩
In female mammals, one of the two X chromosomes is inactivated to compensate for the difference in dosage of X-linked genes between males and females. X inactivation involves sequential alterations to the chromatin that ultimately lead to the transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2da660bc5463864dad64e0271d741
https://hal.archives-ouvertes.fr/hal-02197545
https://hal.archives-ouvertes.fr/hal-02197545
Publikováno v:
Gene Therapy Weekly; 7/3/2023, p1225-1225, 1p
Publikováno v:
Obesity, Fitness & Wellness Week; 6/26/2023, p1137-1137, 1p