Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis

Autor: Martin Jastroch, Florencio Porto Freitas, Carsten Berndt, Daniel Lamp, Marcus Conrad, Antonella Roveri, Sabine Schmitt, Ulrich Schweizer, Lisa Mehr, Wolfgang Wurst, Fulvio Ursini, Axel Walch, Katalin Buday, Elias S.J. Arnér, Tobias Seibt, Xiaoxiao Peng, Sebastian Doll, José Pedro Friedmann Angeli, Noelia Fradejas-Villar, Michaela Aichler, Irina Ingold, Gereon Poschmann, Sayuri Miyamoto, Hans Zischka

Publikováno v: Cell 172, 409–422.e21 (2018)
Cell 172(3), 409-422.e21 (2018). doi:10.1016/j.cell.2017.11.048
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35109d677be425e4813bd942813598d
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52658

The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization

Autor: Carla Boitani, Marcus Conrad, Franco Mangia, Rossella Puglisi, Irene Maccari, Simona Pipolo

Publikováno v: Journal of cellular physiology / Supplement 227(4), 1420-1427 (2012). doi:10.1002/jcp.22857

The nuclear isoform of the selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (nGPx4) is expressed in haploid male germ cells, contains several cysteines and is able to oxidize protein thiols, besides glutathione. In this study we have i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d71deed114765a489bf2d03191983e4
https://doi.org/10.1002/jcp.22857

Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice

Autor: Noblanc, Anaïs, Peltier, Manon, Damon-Soubeyrand, Christelle, Kerchkove, Nicolas, Chabory, Eléonore, Vernet, Patrick, Saez, Fabrice, Cadet, Rémi, Janny, Laurent, Pons-Rejraji, Hanae, Conrad, Marcus, Drevet, Joël, Kocer, Ayhan, Bishop, Alexander James Roy

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e38565. ⟨10.1371/journal.pone.0038565⟩
PLoS ONE, 2012, 7 (6), pp.e38565. ⟨10.1371/journal.pone.0038565⟩
PLoS ONE 7:e38565 (2012)
PLOS ONE 7(6), e38565 (2012). doi:10.1371/journal.pone.0038565
PLoS ONE, Vol 7, Iss 6, p e38565 (2012)

We report here that spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2680fb2aef4c23e568eb5b6f0e9ad344
https://hal.archives-ouvertes.fr/hal-02083321

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

Autor: Ulrike Lichti, Andrew Ryscavage, Christophe Cataisson, Stuart H. Yuspa, Dolph L. Hatfield, Marcus Conrad, Susan M. Fischer, Bradley A. Carlson, Carol Mikulec, Aniruddha Sengupta

Publikováno v: The journal of investigative dermatology 133(7), 1731-1741 (2013). doi:10.1038/jid.2013.52
J. Invest. Dermatol. 133, 1731-1741 (2013)

Selenoproteins are essential molecules for the mammalian antioxidant network. We previously demonstrated that targeted loss of all selenoproteins in mouse epidermis disrupted skin and hair development, and caused premature death. In the current study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce2974c5ec2233c64decbb6efbf0dfd