The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients

Autor: Roman Goetzke, Herdit M. Schüler, Marc Rogers, Ellen Jørum, Angelika Lampert, Martin Hampl, Elisangela Bressan, Anthony M. Rush, Martin Zenke, Zacharias Kohl, Clara M. Kerth, Thi Kim Chi Le, Barbara Namer, Alec Foerster, Petra Hautvast, Martin Schmelz, Corinna Rösseler, Wolfgang Wagner, Kim Le Cann, Inge Petter Kleggetveit, Beate Winner, Jannis E. Meents, Stephanie Sontag

Publikováno v: Pain
Pain : the journal of the International Association for the Study of Pain 160(6), 1327-1341 (2019). doi:10.1097/j.pain.0000000000001511
Pain 160(6), 1327-1341 (2019). doi:10.1097/j.pain.0000000000001511

Supplemental Digital Content is Available in the Text. Human sodium channel NaV1.7 in induced pluripotent stem cell–derived sensory neurons sets the action potential threshold but does not support subthreshold depolarizations.
The chronic pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80927ffc3692702b91e7f7a576388aec
https://pubmed.ncbi.nlm.nih.gov/30720580