Výsledky vyhledávání - "genetics [Cell Survival]"

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

Autor: Sylvia Bolz, Simon J. Clark, Michela Deleidi, Inga Sonntag, Vasiliki Panagiotakopoulou, Anke Jacob, Sabina Honisch, Ellen Kilger, Marius Ueffing, Angela Armento

Publikováno v: Scientific Reports
Scientific reports 10(1), 10320 (2020). doi:10.1038/s41598-020-67292-z
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to compleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b7a6a57d9bcee7f8d8cf617090f2b6
https://pubmed.ncbi.nlm.nih.gov/32587311

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TIP60/KAT5 is required for neuronal viability in hippocampal CA1

Autor: Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban

Publikováno v: Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444ec66987556cb4c7f6b85293f7171
https://doi.org/10.1038/s41598-019-50927-1

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CRELD1 modulates homeostasis of the immune system in mice and humans

Publikováno v: Nature immunology 21(12), 1517-1527 (2020). doi:10.1038/s41590-020-00811-2
Nature Immunology, 21, 1517-1527
Nature Immunology, 21, 12, pp. 1517-1527

CRELD1 is a pivotal factor for heart development, the function of which is unknown in adult life. We here provide evidence that CRELD1 is an important gatekeeper of immune system homeostasis. Exploiting expression variance in large human cohorts cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319f1f62a673e1027e6e8f96e5250f7f
https://pubmed.ncbi.nlm.nih.gov/33169012

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Shedding of BAFF/APRIL Receptors Controls B Cells

Autor: Franziska S. Thaler, Stefan F. Lichtenthaler, Edgar Meinl

Publikováno v: Trends in immunology 39(9), 673-676 (2018). doi:10.1016/j.it.2018.07.002

Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe29343467b0898fbc68ba092415e1ff
https://pubmed.ncbi.nlm.nih.gov/30072119

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Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA

Autor: Bastian Dislich, Stefan F. Lichtenthaler, Shuai Li, Thomas Brocker, Cord Brakebusch

Publikováno v: The journal of immunology 195(9), 4244-4256 (2015). doi:10.4049/jimmunol.1500676

Tissues accommodate defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and environmental stimuli control DC life span and numbers. DC homeostasis in tissues is important, because experimental changes in DC nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062533a50ce7aa260bb62a1f7060ab96
https://doi.org/10.4049/jimmunol.1500676

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EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons

Autor: John D. Murdoch, Siona Freytag, Katja Burk, Ronja Markworth, Camin Dean, Melanie Koenig, Susanne Burkhardt, Andre Fischer, Vinita Bharat

Publikováno v: Scientific reports 7(1), 2149 (2017). doi:10.1038/s41598-017-02202-4
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
Scientific Reports

The sorting of activated receptors into distinct endosomal compartments is essential to activate specific signaling cascades and cellular events including growth and survival. However, the proteins involved in this sorting are not well understood. We

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Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons

Autor: Wolfgang Wurst, Karina Müller-Brown, Thomas Weber, Ralf Kühn, Reinhard W. Köster, Barbara Winter, Kazuhiko Namikawa

Publikováno v: Development 143, 4279-4287 (2016)
Development 143(22), 4279-4287 (2016). doi:10.1242/dev.122721

The zebrafish is a well-established model organism to study in vivo mechanisms of cell communication, differentiation and function. Existing cell ablation methods are either invasive thereby creating additional tissue damage and potential infection s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc47d4925ce3340a842384dbcfe2c0df
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49715

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PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy

Autor: Chantal A. Mutsaers, Ellen J. Bennett, Basil Sharrack, Ke Ning, Chiara F. Valori, Pamela J. Shaw, Thomas H. Gillingwater, Daniel Little, Matthew Wyles, Mimoun Azzouz

Publikováno v: Molecular therapy 23(2), 270-277 (2015). doi:10.1038/mt.2014.209
Molecular Therapy

Spinal muscular atrophy (SMA) is the second most common genetic cause of death in childhood. However, no effective treatment is available to halt disease progression. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene. We previousl

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Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms

Autor: Nicole Wächter, Alexander Storch, Andreas Hermann

Publikováno v: Amyotrophic lateral sclerosis & frontotemporal degeneration 16(7-8), 431-441 (2015). doi:10.3109/21678421.2015.1055275

TAR DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) were recently found to cause familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms by which mutations within these genes cause ALS are not understood. We established m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01c2623b0d27e3783ea1c973dd844e4
https://pub.dzne.de/record/138215

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Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse

Autor: Ernest Arenas, Christof Niehrs, Johannes Beckers, Nilima Prakash, Martin Irmler, Elisabet Andersson, Yoshiyasu Fukusumi, Friederike Matheus, Antonio Simeone, Jingzhong Zhang, Eleonora Minina, Benedict Rauser, Wolfgang Wurst, Sebastian Götz, Ruth Beckervordersandforth, Theresa Faus-Kessler, Florian Meier

Publikováno v: The Journal of neuroscience 35 (2015): 13385–13401. doi:10.1523/JNEUROSCI.1722-15.2015
info:cnr-pdr/source/autori:Fukusumi Y.; Meier F.; Gotz S.; Matheus F.; Irmler M.; Beckervordersandforth R.; Faus-Kessler T.; Minina E.; Rauser B.; Zhang J.; Arenas E.; Andersson E.; Niehrs C.; Beckers J.; Simeone A.; Wurst W.; Prakash N./titolo:Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse/doi:10.1523%2FJNEUROSCI.1722-15.2015/rivista:The Journal of neuroscience/anno:2015/pagina_da:13385/pagina_a:13401/intervallo_pagine:13385–13401/volume:35
J. Neurosci. 35, 13385-13401 (2015)
The journal of neuroscience 35(39), 13385-13401 (2015). doi:10.1523/JNEUROSCI.1722-15.2015
Europe PubMed Central

Wingless-related MMTV integration site 1 (WNT1)/β-catenin signaling plays a crucial role in the generation of mesodiencephalic dopaminergic (mdDA) neurons, including the substantia nigra pars compacta (SNc) subpopulation that preferentially degenera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d349b8e2571e4b6ce5ac7ab2eea3f26a
https://www.jneurosci.org/content/35/39/13385

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