Zobrazeno 1 - 10
of 58
pro vyhledávání: '"genetics [Apolipoproteins E]"'
Autor:
Jansen, Iris, van der Lee, Sven J, Bellenguez, Céline, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Rujescu, Dan, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Schneider, Anja, Selbæk, Geir, Kleineidam, Luca, Selnes, Per, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tárraga, Lluís, Teipel, Stefan, group, GR@ACE study, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Küçükali, Fahri, Van Dongen, Jasper, van Swieten, John C, Vandenberghe, Rik, Vidal, Jean-Sébastien, Visser, Pieter J, Vogelgsang, Jonathan, Waern, Margda, Wagner, Michael, Wiltfang, Jens, Wittens, Mandy M J, Sung, Yun Ju, Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M, Bjerke, Maria, Engelborghs, Sebastiaan, Jessen, Frank, Teunissen, Charlotte E, Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Tesí, Niccolo, Andreassen, Ole A, Clarimón, Jordi, Sleegers, Kristel, Ruiz, Agustín, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles, van der Flier, Wiesje, Vromen, Ellen M, Wightman, Douglas P, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Gomez-Fonseca, Duber, Amouyel, Philippe, Athanasiu, Lavinia, Bahrami, Shahram, Bailly, Henri, Belbin, Olivia, Bergh, Sverre, Bertram, Lars, Biessels, Geert Jan, Blennow, Kaj, Blesa, Rafael, de Rojas, Itziar, Boada, Mercè, Boland, Anne, Bürger, Katharina, Carracedo, Ángel, Cervera-Carles, Laura, Chene, Geneviève, Claassen, Jurgen A H R, Debette, Stephanie, Deleuze, Jean-Francois, de Deyn, Peter Paul, Dalmasso, Maria Carolina, Diehl-Schmid, Janine, Djurovic, Srdjan, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Düzel, Emrah, consortium, EADB, Fladby, Tormod, Fortea, Juan, Frölich, Lutz, Grenier-Boley, Benjamin, García-González, Pablo, Garcia-Martinez, Maria, Giegling, Ina, Goldhardt, Oliver, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Zettergren, Anna, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael, Hernández, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Kern, Silke, Knapskog, Anne-Brita, Koivisto, Anne M, Mishra, Aniket, Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleó, Alberto, de Munain, Adolfo López, Lopez-Garcia, Sara, Maier, Wolfgang, Ali, Muhammad, Marquié, Marta, Mol, Merel O, Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Nöthen, Markus M, Orellana, Adelina, Pålhaugen, Lene, Papma, Janne M, Andrade, Victor, Pasquier, Florence, Perneczky, Robert, Peters, Oliver, Pijnenburg, Yolande A L, Popp, Julius, Posthuma, Danielle, Pozueta, Ana, Priller, Josef, Puerta, Raquel, Quintela, Inés
Publikováno v:
EADB consortium & The GR@ACE study group 2022, ' Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers ', Acta Neuropathologica, vol. 144, no. 5, pp. 821-842 . https://doi.org/10.1007/s00401-022-02454-z
Acta Neuropathologica, 7(11), 2474-2483. SPRINGER
Acta neuropathologica 144(5), 821-842 (2022). doi:10.1007/s00401-022-02454-z
Acta Neuropathologica, 144(5), 821-842. Springer Verlag
Acta Neuropathologica, 144(5), 821-842. Springer, Cham
Acta Neuropathologica. Springer Verlag
European Alzheimer & Dementia BioBank (EADB) 2022, ' Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers ', Acta Neuropathologica, vol. 144, no. 5, pp. 821-842 . https://doi.org/10.1007/s00401-022-02454-z, https://doi.org/10.1007/s00401-022-02454-z
2022, ' Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers ', Acta Neuropathologica . https://doi.org/10.1007/s00401-022-02454-z
ACTA NEUROPATHOLOGICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Acta Neuropathologica
Acta neuropathologica
Acta Neuropathologica, 144(5), 821-842. Springer-Verlag
Acta Neuropathol . 2022 Nov;144(5):821-842
Acta Neuropathologica, 7(11), 2474-2483. SPRINGER
Acta neuropathologica 144(5), 821-842 (2022). doi:10.1007/s00401-022-02454-z
Acta Neuropathologica, 144(5), 821-842. Springer Verlag
Acta Neuropathologica, 144(5), 821-842. Springer, Cham
Acta Neuropathologica. Springer Verlag
European Alzheimer & Dementia BioBank (EADB) 2022, ' Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers ', Acta Neuropathologica, vol. 144, no. 5, pp. 821-842 . https://doi.org/10.1007/s00401-022-02454-z, https://doi.org/10.1007/s00401-022-02454-z
2022, ' Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers ', Acta Neuropathologica . https://doi.org/10.1007/s00401-022-02454-z
ACTA NEUROPATHOLOGICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Acta Neuropathologica
Acta neuropathologica
Acta Neuropathologica, 144(5), 821-842. Springer-Verlag
Acta Neuropathol . 2022 Nov;144(5):821-842
Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Bi
Autor:
Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Piña‐Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia TCW, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C. Carrillo
Publikováno v:
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G M, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity : Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
Alzheimer's and dementia 19(6), 2677-2696 (2023). doi:10.1002/alz.13020
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity: Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
Alzheimer's and dementia 19(6), 2677-2696 (2023). doi:10.1002/alz.13020
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity: Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d9ff92093ab0b6d772041ff569c18f
https://research.vumc.nl/en/publications/823b40ac-c075-4456-8a2d-bdf139906d29
https://research.vumc.nl/en/publications/823b40ac-c075-4456-8a2d-bdf139906d29
Autor:
Luo, Jingqin, Agboola, Folasade, Hassenstab, Jason, Bateman, Randall J, Perrin, Richard J, Wang, Guoqiao, Li, Yan, Gordon, Brian, Cruchaga, Carlos, Day, Gregory S, Levin, Johannes, Vöglein, Jonathan, Grant, Elizabeth, Ikeuchi, Takeshi, Suzuki, Kazushi, Allegri, Ricardo F, Xiong, Chengjie, Network, Dominantly Inherited Alzheimer, Morris, John C, Masters, Colin L, Albert, Marilyn S, Johnson, Sterling C, McDade, Eric M, Fagan, Anne M, Benzinger, Tammie L S
Publikováno v:
Brain 145(12), 4459-4473 (2022). doi:10.1093/brain/awac238
Brain
Brain
The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the molecular imaging of cereb
Autor:
Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Publikováno v:
Brain 145(4), 1473-1485 (2022). doi:10.1093/brain/awab405
We investigated whether the impact of tau-pathology on memory performance and on hippocampal/medial temporal memory function in non-demented individuals depends on the presence of amyloid pathology, irrespective of diagnostic clinical stage. We condu
Autor:
Christos Koros, Kathrin Brockmann, Athina‐Maria Simitsi, Anastasia Bougea, Hui Liu, Ann‐Kathrin Hauser, Claudia Schulte, Stefanie Lerche, Ioanna Pachi, Nikolaos Papagiannakis, Roubina Antonelou, Athina Zahou, Isabel Wurster, Efthymia Efthymiopoulou, Ion Beratis, Matina Maniati, Marina Moraitou, Helen Michelakakis, Georgios Paraskevas, Sokratis G. Papageorgiou, Constantin Potagas, Dimitra Papadimitriou, Maria Bozi, Maria Stamelou, Thomas Gasser, Leonidas Stefanis
Publikováno v:
Movement disorders 38(5), 907-909 (2023). doi:10.1002/mds.29399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead54194927ab5e957b136a2e058c5da
Autor:
Belloy, Michael E, Eger, Sarah J, de Rojas, Itziar, Parveen, Kayenat, Sleegers, Kristel, Ingelsson, Martin, Hiltunen, Mikko, Amin, Najaf, Andreassen, Ole A, Sánchez-Juan, Pascual, Kehoe, Patrick Gavin, Amouyel, Philippe, Le Guen, Yann, Sims, Rebecca, Frikke-Schmidt, Ruth, van der Flier, Wiesje M, Lambert, Jean-Charles, BioBank, European Alzheimer & Dementia, He, Zihuai, Han, Summer S, Napolioni, Valerio, Greicius, Michael D, Damotte, Vincent, Ahmad, Shahzad, Ikram, M Arfan, Ramirez, Alfredo, Tsolaki, Anthoula C, Rossi, Giacomina, Jansen, Iris
Publikováno v:
Alzheimer's Research & Therapy, 14(1):22. BioMed Central
Alzheimer's Research & Therapy
Alzheimer's research & therapy
Belloy, M E, Eger, S J, Le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J C, He, Z, Han, S S, Napolioni, V, Greicius, M D & European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's research & therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Belloy, M E, Eger, S J, le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J-C, He, Z, Han, S S, European Alzheimer & Dementia BioBank (EADB), Napolioni, V & Greicius, M D 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22, pp. 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy, 14(1):22. BioMed Central Ltd.
for the European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research and Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy 14(1), 22 (2022). doi:10.1186/s13195-022-00962-4
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's Research and Therapy, 14(1):22. BioMed Central
Alzheimer's Research & Therapy
Alzheimer's research & therapy
Belloy, M E, Eger, S J, Le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J C, He, Z, Han, S S, Napolioni, V, Greicius, M D & European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's research & therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Belloy, M E, Eger, S J, le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J-C, He, Z, Han, S S, European Alzheimer & Dementia BioBank (EADB), Napolioni, V & Greicius, M D 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22, pp. 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy, 14(1):22. BioMed Central Ltd.
for the European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research and Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy 14(1), 22 (2022). doi:10.1186/s13195-022-00962-4
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's Research and Therapy, 14(1):22. BioMed Central
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of APOE pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a0c24c1a766cc73a83686215b99c5f
https://research.vumc.nl/en/publications/6828c379-3698-4b23-83ed-db73135922c1
https://research.vumc.nl/en/publications/6828c379-3698-4b23-83ed-db73135922c1
Autor:
Fagan, Anne M, Henson, Rachel L, Lai, Florence, Rosas, H Diana, Schupf, Nicole, Krinsky-McHale, Sharon, Silverman, Wayne, Lee, Joseph H, Klunk, William E, Handen, Benjamin L, Allegri, Ricardo F, Chhatwal, Jasmeer P, Li, Yan, Day, Gregory S, Graff-Radford, Neill R, Jucker, Mathias, Levin, Johannes, Martins, Ralph N, Masters, Colin L, Mori, Hiroshi, Mummery, Catherine J, Niimi, Yoshiki, Ringman, John M, Boerwinkle, Anna H, Salloway, Stephen, Schofield, Peter R, Shoji, Mikio, Lott, Ira T, Syndrome, Alzheimer's Biomarker Consortium-Down, Network, Dominantly Inherited Alzheimer, Xiong, Chengjie, Bateman, Randall J, Goate, Alison, Ances, Beau M, Doran, Eric, Christian, Bradley T
Publikováno v:
The lancet / Neurology 20(8), 615-626 (2021). doi:10.1016/S1474-4422(21)00139-3
Lancet Neurol
Lancet Neurol
Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increa
Autor:
Ioannis K Zarkadis, Pavlos Beis, Michail Niforas, Polychronis Economou, Robert Perneczky, Johannes Kornhuber, Aggeliki Kormpaki, Panagiotis Alexopoulos, Theodore G Dassios, Martin Reichel, Philippos Gourzis, Anastasios D Papanastasiou
Publikováno v:
Journal of neural transmission 128(1), 105-114 (2021). doi:10.1007/s00702-020-02280-1
Apolipoprotein E (APOE) ε, catechol-O-methytranferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphisms (SNPs) were shown to affect stress perception and response. The present study explored p
Autor:
Müller, Theresa, Payton, Nicola M., Kalpouzos, Grégoria, Jessen, Frank, Grande, Giulia, Bäckman, Lars, Laukka, Erika J.
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease 77(4), 1443-1453 (2020). doi:10.3233/JAD-200445
Journal of Alzheimer's disease 77(4), 1443-1453 (2020). doi:10.3233/JAD-200445
Background: Although associated with dementia and cognitive impairment, microstructural white matter integrity is a rarely used marker of preclinical dementia. Objective: We aimed to evaluate the individual and combined effects of multiple markers, w
Autor:
Hendrik van den Bussche, Francisca S. Rodriguez, Birgitt Wiese, Christian Brettschneider, Alexander Pabst, Michael Pentzek, Steffen Wolfsgruber, Michael Wagner, Jochen Werle, Hans-Helmut König, Luca Kleineidam, Martin Scherer, Dagmar Lühmann, Steffi G. Riedel-Heller, Horst Bickel, Angela Fuchs, Dagmar Weeg, Siegfried Weyerer, Susanne Roehr, Wolfgang Maier
Publikováno v:
International journal of geriatric psychiatry 36(1), 152-162 (2021). doi:10.1002/gps.5409
Objectives Previous studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's ge