Výsledky vyhledávání - "genetics [Adaptor Proteins, Vesicular Transport]"

Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis

Autor: Markus Zweckstetter, King Faisal Yambire, Niels Denkert, Claudia Steinem, Nelli Teske, Daryna Tarasenko, Michael Meinecke, Ira Milosevic, Indrani Mukherjee, Garima Jaipuria, Benjamin Kroppen

Publikováno v: Cellular and Molecular Life Sciences
Cellular and molecular life sciences 78(5), 2355-2370 (2021). doi:10.1007/s00018-020-03647-z

Membrane remodeling is a critical process for many membrane trafficking events, including clathrin-mediated endocytosis. Several molecular mechanisms for protein-induced membrane curvature have been described in some detail. Contrary, the effect that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299604b0231580d1487db82e8f61580b
https://doi.org/10.1007/s00018-020-03647-z

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A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

Autor: Jana Enderes, Shilpashree Mallesh, Reiner Schneider, Kristof J. Hupa, Mariola Lysson, Bianca Schneiker, Kristian Händler, Balthasar Schlotmann, Patrick Günther, Joachim L. Schultze, Jörg C. Kalff, Sven Wehner

Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Frontiers in immunology 11, 581111 (2021). doi:10.3389/fimmu.2020.581111

Postoperative ileus (POI) is triggered by an innate immune response in the muscularis externa (ME) and is accompanied by bacterial translocation. Bacteria can trigger an innate immune response via toll-like receptor (TLR) activation, but the latter�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d7e5b71452e66799627b2f4a685bb3
https://doi.org/10.3389/fimmu.2020.581111

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Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

Autor: Antonino Asaro, Joerg Heeren, Thomas E. Willnow, Oliver Peters, Anne-Sophie Carlo-Spiewok, Michael Rothe, Carola G. Schipke, Anna R. Malik

Publikováno v: Asaro, A, Carlo-Spiewok, A-S, Malik, A R, Rothe, M, Schipke, C G, Peters, O, Heeren, J & Willnow, T E 2020, ' Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling ', Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 16, no. 9, pp. 1248-1258 . https://doi.org/10.1002/alz.12121
Alzheimer's and dementia 16(9), 1248-1258 (2020). doi:10.1002/alz.12121

INTRODUCTIONApoE is a carrier for brain lipids and the most important genetic risk factor for Alzheimer’s disease (AD). ApoE binds the receptor sortilin which mediates uptake of apoE-bound cargo into neurons. The significance of this uptake route f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9f366d18c18c60415907d0840e76a4
https://pure.au.dk/portal/da/publications/apolipoprotein-e4-disrupts-the-neuroprotective-action-of-sortilin-in-neuronal-lipid-metabolism-and-endocannabinoid-signaling(3eab6895-ace1-4c85-9e04-b34207a00d19).html

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Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

Autor: Jasmin E. Hanke, Karsten Hiller, Jan Gehlen, Eicke Latz, Axel Imhof, Maike Kreutzenbeck, Gudrun Engels, Florian Hoss, Magdalini Serefidou, Carl-Christian Kolbe, Matthew Mangan, Anette Christ, Romina Kaiser, Maximilian Rothe, Timo Hess, Mario A. Lauterbach, Susanne V. Schmidt

Publikováno v: Immunity 51(6), 997-1011.e7 (2019). doi:10.1016/j.immuni.2019.11.009

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades. Whether concurrent changes in the cellular metabolism that occur upon TLR activation influence the quality of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32b618b93858d63644dcd091845898c
https://pubmed.ncbi.nlm.nih.gov/31948874

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S100-alarmin-induced innate immune programming protects newborn infants from sepsis

Publikováno v: Nature immunology 18(6), 622-632 (2017). doi:10.1038/ni.3745

The high risk of neonatal death from sepsis is thought to result from impaired responses by innate immune cells; however, the clinical observation of hyperinflammatory courses of neonatal sepsis contradicts this concept. Using transcriptomic, epigene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4ecad34f573f2d5802aeb8933f93fc
https://pubmed.ncbi.nlm.nih.gov/28926540

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Ubiquitin-specific protease USP36 knockdown impairs Parkin-dependent mitophagy via downregulation of Beclin-1-associated autophagy-related ATG14L

Autor: Anna Lechado Terradas, Friederike Hans, Sonia Golombek, Sven Geisler, Caren Linnemann, Etsuro Nakanishi, Lea Jäger, Nicolas Casadei, Philipp J. Kahle

Publikováno v: Experimental cell research 384(2), 111641 (2019). doi:10.1016/j.yexcr.2019.111641

Parkin is an ubiquitin ligase regulating mitochondrial quality control reactions, including the autophagic removal of depolarized mitochondria (mitophagy). Parkin-mediated protein ubiquitinations may be counteracted by deubiquitinating enzymes (DUBs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9699e494c46184a2a3abb8b9e13a1c01
https://doi.org/10.1016/j.yexcr.2019.111641

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Mutations in ap1b1 Cause Mistargeting of the Na+/K+-ATPase Pump in Sensory Hair Cells

Autor: Bettina Schmid, Karin Finger-Baier, Katie S. Kindt, Teresa Nicolson, Rachel Clemens Grisham

Publikováno v: PLoS ONE
PLoS One
PLoS ONE, Vol 8, Iss 4, p e60866 (2013)
PLOS ONE 8(4), e60866 (2013). doi:10.1371/journal.pone.0060866

The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle. Mechanotransduction occurs within the hair bundle, whereas synaptic transmission takes place at the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e429ea408b62e14e8f7ee90d8b168873
https://doi.org/10.1371/journal.pone.0060866

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