Zobrazeno 1 - 4
of 4
pro vyhledávání: '"genetics, Caspase 1"'
Autor:
Sabine J. Wölfle, Julia S. Frick, Andre Fischer, Sarah Menz, Melanie R. Shakespear, Judith Knievel, Julian David Langer, Liliana Schaefer, Dominik Stammler, Konrad A. Bode, Jonathan Jantsch, Klaus Heeg, Ina Oehme, Tatjana Eigenbrod, Isabel Siegert, Alexander H. Dalpke, Matthew J. Sweet
Publikováno v:
The journal of immunology 195(11), 5421-5431 (2015). doi:10.4049/jimmunol.1501195
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and muri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d790a8a880fbfadefa2bda86ca77cda
https://doi.org/10.4049/jimmunol.1501195
https://doi.org/10.4049/jimmunol.1501195
Autor:
Simone Hornemann, Gudrun Engels, Philip M. Hansbro, Matthew Mangan, Christoph Brenker, Terje Espevik, Martin Fricke, Ashraf Al-Amoudi, Bernardo S. Franklin, Andrew G. Jarnicki, Dominic De Nardo, Adriano Aguzzi, Bernadette Jones, Ann Marshak-Rothstein, Patricia Busto, Eicke Latz, Brian G. Monks, Sandra R Mirandola, Lukas Bossaller, Sebastian Zimmer, Andrea Stutz, Mark Nordhoff, Wolfgang Kastenmüller, Jacqueline M Ratter, Reinhold E. Schmidt
Publikováno v:
NATURE IMMUNOLOGY
Nature Immunology
Nature immunology 15(8), 727-737 (2014). doi:10.1038/ni.2913
Nature Immunology
Nature immunology 15(8), 727-737 (2014). doi:10.1038/ni.2913
Microbes or danger signals trigger inflammasome sensors, which induce polymerization of the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-1, which induces maturation of the cytokine interleukin 1β (IL-1β) and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c0f177a0bc33d6a2dafccc3a4f5880
https://doi.org/10.1038/ni.2913
https://doi.org/10.1038/ni.2913
Autor:
Anselmo Jiro Kamada, Telma Miyuki Oshiro, Alberto José da Silva Duarte, Sergio Crovella, Alessandra Pontillo, Martina Girardelli
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 59:121-125
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c11610794e55a268a9283a3cc19e3a0
https://doi.org/10.1097/qai.0b013e3182392ebe
https://doi.org/10.1097/qai.0b013e3182392ebe
Autor:
Ellen Gelpi, Annett Halle, Markus P. Kummer, Daisy Axt, Andrea Delekate, Anita Remus, Douglas T. Golenbock, Te-Chen Tzeng, Andrea Stutz, Eicke Latz, Martin Korte, Stephanie Schwartz, Ana Vieira-Saecker, Michael T. Heneka, Angelika Griep
Publikováno v:
Nature 493(7434), 674-678 (2012). doi:10.1038/nature11729
Nature
Nature
Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-beta peptide drives cerebral neuroinflammation by activating microglia. Indeed, amyloid-beta activation of the NLRP3 inflammasome in microglia is fundamental for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f0acc3be46a195a5da2f36c54b2d1b
https://pub.dzne.de/record/136774
https://pub.dzne.de/record/136774
