Zobrazeno 1 - 10
of 110
pro vyhledávání: '"genetically modified pigs"'
Autor:
Mengyi CUI, Leijia CHEN, Yuanyuan LI, Kai WANG, Shengfeng CHEN, Boyao YANG, Xiangyu SONG, Zhibo JIA, Haochen ZUO, Wenjing XU, Jiang PENG
Publikováno v:
Zhongguo shuxue zazhi, Vol 37, Iss 5, Pp 607-612 (2024)
Although blood banks based on human blood can provide blood transfusions for the wounded timely and effectively, scientific research has never given up on finding new blood sources due to the restrictions of human blood sources. With the application
Externí odkaz:
https://doaj.org/article/68230e860d334d1eaf12e72da49d6720
Autor:
Yinglin Yuan, Yuanyuan Cui, Dayue Zhao, Yuan Yuan, Yanshuang Zhao, Danni Li, Xiaomei Jiang, Gaoping Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising option due to the greater availability of donor organs. However, significant hurdles such as hype
Externí odkaz:
https://doaj.org/article/652fab7f5c3f4fc1b0af95548f2b5781
Autor:
Juhye Roh, Jeong Ho Hwang, Sangkeun Park, Haneulnari Lee, Eun Mi Park, Hye Won Lee, Ju Young Lee, Joohyun Shim, Kimyung Choi, Hee Jung Kang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDecreasing rates of blood donation and close margins between blood supply and demand pose challenges in healthcare. Genetically engineered pig red blood cells (pRBCs) have been explored as alternatives to human RBCs for transfusion, and t
Externí odkaz:
https://doaj.org/article/0a960c5eac8743d58a906160e83f66aa
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
In the quest to address the critical shortage of donor organs for transplantation, xenotransplantation stands out as a promising solution, offering a more abundant supply of donor organs. Yet, its widespread clinical adoption remains hindered by sign
Externí odkaz:
https://doaj.org/article/7a50bd8a18994a65b83a2f0e6971a053
Autor:
Xiaojian Zhang, Hailian Wang, Qin Xie, Yang Zhang, Yixin Yang, Man Yuan, Yuqi Cui, Si-Yuan Song, Jianzhen Lv, Yi Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Xenotransplantation is emerging as a vital solution to the critical shortage of organs available for transplantation, significantly propelled by advancements in genetic engineering and the development of sophisticated immunosuppressive treatments. Sp
Externí odkaz:
https://doaj.org/article/0aed803885ed45c3bbdd6a233bd1e10f
Autor:
Sangkeun Park, Haneulnari Lee, Eun Mi Park, Juhye Roh, Pul Ip Kang, Joohyun Shim, Kimyung Choi, Hee Jung Kang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The decline in blood donation rates and the ongoing shortage of blood products pose significant challenges to medical societies. One potential solution is to use porcine red blood cells (pRBCs) from genetically modified pigs as an alternative to huma
Externí odkaz:
https://doaj.org/article/1d39a31ae8fa43e29bd45691279f952c
Autor:
Nathalia L. M. Lara, Taylor Goldsmith, Paula Rodriguez-Villamil, Felipe Ongaratto, Staci Solin, Dennis Webster, Uyanga Ganbaatar, Shane Hodgson, Stanislas M. A. S. Corbière, Alla Bondareva, Daniel F. Carlson, Ina Dobrinski
Publikováno v:
Cells, Vol 12, Iss 21, p 2582 (2023)
Spermatogonial stem cell (SSC) transplantation into the testis of a germ cell (GC)-depleted surrogate allows transmission of donor genotype via donor-derived sperm produced by the recipient. Transplantation of gene-edited SSCs provides an approach to
Externí odkaz:
https://doaj.org/article/4b9227e67f8848e5932898ad4a095fa8
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Xenotransplantation has the potential to solve the shortfall of human organ donors. Genetically modified pigs have been considered as potential animal donors for human xenotransplantation and have been widely used in preclinical research. The genetic
Externí odkaz:
https://doaj.org/article/4318d21f7f344ee3b312fd42699c2c85
Publikováno v:
Journal of Integrative Agriculture, Vol 18, Iss 6, Pp 1329-1336 (2019)
CRISPR/Cpf1 has emerged recently as an effective tool for genome editing in many organisms, but its use in pigs to generate precise genetic modifications has seldom been described. Myostatin (MSTN) is a well-characterized negative regulator of muscle
Externí odkaz:
https://doaj.org/article/7e0411ecc9f348dba3a0ffbdd33b50d7
Autor:
Yao-Wen Song, Zhi-Qiang Pan
Publikováno v:
International Journal of Ophthalmology, Vol 12, Iss 2, Pp 324-332 (2019)
Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans. However, the xenoimmune rejection induced by porcine corneal xenotransplantati
Externí odkaz:
https://doaj.org/article/d75000a600d54680983c6f79b42c9586