Zobrazeno 1 - 10
of 188
pro vyhledávání: '"genetic vector"'
Autor:
Gonzalo Encina Silva
Publikováno v:
Revista Médica Clínica Las Condes, Vol 33, Iss 2, Pp 109-118 (2022)
Resumen: Desde que se introdujo el concepto, en la década de los 70, de tratar una enfermedad reemplazando en el paciente su DNA dañado por un DNA corregido, la terapia genética ha prometido revolucionar la medicina. El primer modelo de trabajo se
Externí odkaz:
https://doaj.org/article/2c683ecda2654bd3a4a4a270d3838dec
Publikováno v:
Frontiers in Ophthalmology, Vol 2 (2023)
Leber’s hereditary optic neuropathy (LHON) is a fairly prevalent mitochondrial disorder (1:50,000) arising from the dysfunction of the mitochondrial respiratory chain, which eventually leads to apoptosis of retinal ganglion cells. The usual present
Externí odkaz:
https://doaj.org/article/fdacf2e4760d476995863b1977534eaa
Publikováno v:
Royal Society Open Science, Vol 8, Iss 3 (2021)
The relative risk of disease transmission caused by the potential release of transgenic vectors, such as through sterile insect technique or gene drive systems, is assessed with comparison with wild-type vectors. The probabilistic risk framework is d
Externí odkaz:
https://doaj.org/article/495206a0febf4cf8a5236bd8528361b5
Autor:
Francesca Malagrinò, Serena Rinaldo, Angelo Toto, Stefano Gianni, Caterina Nardella, Livia Pagano
Publikováno v:
Protein Science : A Publication of the Protein Society
SH2 domains are a class of protein–protein interaction modules with the function to recognize and bind sequences characterized by the presence of a phosphorylated tyrosine. SHP2 is a protein phosphatase involved in the Ras‐ERK1/2 signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d137c45dc16176581577f9ddbb6ff6
https://doi.org/10.1002/pro.4201
https://doi.org/10.1002/pro.4201
Publikováno v:
Innovative Biosystems and Bioengineering; Vol. 6 No. 2 (2022); 48-55
Innovative Biosystems and Bioengineering; Том 6 № 2 (2022); 48-55
Innovative Biosystems and Bioengineering; Том 6 № 2 (2022); 48-55
Background. Current methods of targeted cancer therapy are not always effective enough and can lead to side effects, such as an increased risk of autoimmune diseases. It is known that some bacteria are capable of specific accumulation in malignant tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=scientific_p::841f3e0be51e06f4165d3d2fb9321c76
http://ibb.kpi.ua/article/view/260183
http://ibb.kpi.ua/article/view/260183
Autor:
Maxwell J. Scott
Publikováno v:
Current Biology
Summary The insect sex determination and the intimately linked dosage compensation pathways represent a challenging evolutionary puzzle that has been solved only in Drosophila melanogaster. Analyses of orthologs of the Drosophila genes identified in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dceed4b27368a52a5cfae23114e7a45c
https://doi.org/10.1016/j.cub.2021.01.078
https://doi.org/10.1016/j.cub.2021.01.078
Autor:
Nasrollah Samiy
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 9, Iss 4, Pp 506-509 (2014)
Gene therapy has a growing research potential particularly in the field of ophthalmic and retinal diseases owing to three main characteristics of the eye; accessibility in terms of injections and surgical interventions, its immune-privileged status f
Externí odkaz:
https://doaj.org/article/d5e1cd18725e4760849edcf723f971b2
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 16, Iss 2, Pp 150-156 (2013)
Externí odkaz:
https://doaj.org/article/00ad16ad690048a188b291088d3b02cf
Autor:
Patrizia Tornabene, Rita Ferla, Manel Llado-Santaeularia, Miriam Centrulo, Margherita Dell’Anno, Federica Esposito, Elena Marrocco, Emanuela Pone, Renato Minopoli, Carolina Iodice, Edoardo Nusco, Settimio Rossi, Hristiana Lyubenova, Anna Manfredi, Lucio Di Filippo, Antonella Iuliano, Annalaura Torella, Giulio Piluso, Francesco Musacchia, Enrico Maria Surace, Davide Cacchiarelli, Vincenzo Nigro, Alberto Auricchio
Challenges to the widespread application of gene therapy with adeno-associated viral (AAV) vectors include dominant conditions due to gain-of-function mutations which require allele-specific knockout, as well as long-term transgene expression from pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddefe9337552842eca9f4efdc9c2f5d
http://hdl.handle.net/11591/476671
http://hdl.handle.net/11591/476671
Autor:
Francesca Tucci, Stefania Galimberti, Luigi Naldini, Maria Grazia Valsecchi, Alessandro Aiuti
Ex-vivo gene therapy (GT) with hematopoietic stem and progenitor cells (HSPCs) engineered with integrating vectors is a promising treatment for monogenic diseases, but lack of centralized databases is hampering an overall outcomes assessment. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00425b786c2b4650c4f8222c39f88dd5
http://hdl.handle.net/10281/372387
http://hdl.handle.net/10281/372387