Zobrazeno 1 - 10
of 69
pro vyhledávání: '"genetic targeting"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies. However, its efficacy in solid tumors is limited by the immunosuppressive tumor microenvironment that compromises CAR T cell antit
Externí odkaz:
https://doaj.org/article/ccb122380320458c812a0254c4100a1e
Autor:
João André Sousa, Catarina Bernardes, Sara Bernardo-Castro, Miguel Lino, Inês Albino, Lino Ferreira, José Brás, Rita Guerreiro, Miguel Tábuas-Pereira, Inês Baldeiras, Isabel Santana, João Sargento-Freitas
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two unique central nervous system vasculature features that result in an intimate relationship between neurons, glia, and blood vessels. This leads to a significant
Externí odkaz:
https://doaj.org/article/ec0eea72fb9647388fc31765fe29ad4d
Autor:
Hirrlinger, Johannes, Nimmerjahn, Axel
Studies over the past two decades have demonstrated that astrocytes are tightly associated with neurons and play pivotal roles in neural circuit development, operation, and adaptation in health and disease. Nevertheless, precisely how astrocytes inte
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A88279
https://ul.qucosa.de/api/qucosa%3A88279/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A88279/attachment/ATT-0/
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Adeno-associated viral (AAV) vectors, used as vehicles for gene transfer into the brain, are a versatile and powerful tool of modern neuroscience that allow identifying specific neuronal populations, monitoring and modulating their activity. For cons
Externí odkaz:
https://doaj.org/article/929b174d658a488aba05af84669ab049
Autor:
Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh, Jamshid Hadjati
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-12 (2020)
Abstract Background CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigens and immunosuppressi
Externí odkaz:
https://doaj.org/article/5b310d669cd04b8280bb4d8569a0d14d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Steven Knafo, Kevin Fidelin, Andrew Prendergast, Po-En Brian Tseng, Alexandre Parrin, Charles Dickey, Urs Lucas Böhm, Sophie Nunes Figueiredo, Olivier Thouvenin, Hugues Pascal-Moussellard, Claire Wyart
Publikováno v:
eLife, Vol 6 (2017)
Despite numerous physiological studies about reflexes in the spinal cord, the contribution of mechanosensory feedback to active locomotion and the nature of underlying spinal circuits remains elusive. Here we investigate how mechanosensory feedback s
Externí odkaz:
https://doaj.org/article/77953aa9f82c4fb0b8a013e47962fbd2
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
During the last two decades numerous genetic approaches affecting cell function in vivo have been developed. Current state-of-the-art technology permits the selective switching of gene function in distinct cell populations within the complex organiza
Externí odkaz:
https://doaj.org/article/90ddf675a7d841bf8eda9a0b5e111064