Zobrazeno 1 - 10
of 5 871
pro vyhledávání: '"genetic screen"'
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Congenital heart disease (CHD) is the most prevalent congenital anomaly, but its underlying causes are still not fully understood. It is believed that multiple rare genetic mutations may contribute to the development of CHD. Metho
Externí odkaz:
https://doaj.org/article/99b31b01d87347efb6e288da8f044c74
Autor:
Xue Liu, Vincent de Bakker, Maria Victoria Heggenhougen, Marita Torrissen Mårli, Anette Heidal Frøynes, Zhian Salehian, Davide Porcellato, Danae Morales Angeles, Jan-Willem Veening, Morten Kjos
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Antibiotic resistance and tolerance remain a major problem for the treatment of staphylococcal infections. Identifying genes that influence antibiotic susceptibility could open the door to novel antimicrobial strategies, including targets fo
Externí odkaz:
https://doaj.org/article/e408a377f78a4ede9c4a628939f6f6e4
Publikováno v:
Plant Direct, Vol 8, Iss 6, Pp n/a-n/a (2024)
Abstract Exocytosis plays an essential role in delivering proteins, lipids, and cell wall polysaccharides to the plasma membrane and extracellular spaces. Accurate secretion through exocytosis is key to normal plant development as well as responses t
Externí odkaz:
https://doaj.org/article/35f2e96c5c5c4989a143a6f23efe87b3
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years
Externí odkaz:
https://doaj.org/article/5a1806decbf14923b09c43658da6c045
Autor:
Mélissa Caza, Daniel Assis Santos, Elizabeth Burden, Anna Brisland, Guanggan Hu, James W. Kronstad
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT The current therapeutic challenges for treating fungal diseases demand new approaches and new drugs. A promising strategy involves combination therapy with agents of distinct mechanisms of action to increase fungicidal activity and limit the
Externí odkaz:
https://doaj.org/article/7222de6af4c347b8aaa3e56556aefc15
Autor:
Renaud L. M. Tissier, Janne J. M. van Schie, Rob M. F. Wolthuis, Job de Lange, Renée de Menezes
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background CRISPR screens provide large-scale assessment of cellular gene functions. Pooled libraries typically consist of several single guide RNAs (sgRNAs) per gene, for a large number of genes, which are transduced in such a way that ever
Externí odkaz:
https://doaj.org/article/aae7e52e22ba42efa7783aa38dc7a984
Autor:
Mingzhong Xie, Haoping Dai, Qingwen Gu, Changming Xiao, Haozhong Wang, Yang Lei, Chunxiao Wu, Xuening Li, Birong Lin, Sen Li
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 164-173 (2023)
Osteosarcomas are prevalent in children and young adults and have a high recurrence rate. Cisplatin, doxorubicin, and methotrexate are common adjuvant chemotherapy drugs for treatment of osteosarcoma, but multidrug resistance is a growing problem. Th
Externí odkaz:
https://doaj.org/article/6cc58b5134214e10bbd8b3e4fc2d0c69
Autor:
Shannon L. Moore, Frank C. Adamini, Erik S. Coopes, Dustin Godoy, Shyra J. Northington, Jordan M. Stewart, Richard L Tillett, Kayla L. Bieser, Jacob D. Kagey
Publikováno v:
Fly, Vol 16, Iss 1, Pp 176-189 (2022)
Genetic screens are used in Drosophila melanogaster to identify genes key in the regulation of organismal development and growth. These screens have defined signalling pathways necessary for tissue and organismal development, which are evolutionarily
Externí odkaz:
https://doaj.org/article/3d568f70428043109838e69945fecae5
Autor:
Kathy H. Li, Bingying Wang, Roman Vozdek, Andrew A. Hicks, Peter P. Pramstaller, Dengke K. Ma
Publikováno v:
Open Research Europe, Vol 2 (2023)
Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood. Here, we used protein interactor and gene
Externí odkaz:
https://doaj.org/article/89e4ea6c0f934c1dbba1b4ba7c10fabe
Autor:
Ida L Barlow, Eirinn Mackay, Emily Wheater, Aimee Goel, Sumi Lim, Steve Zimmerman, Ian Woods, David A Prober, Jason Rihel
Publikováno v:
eLife, Vol 12 (2023)
Sleep is a nearly universal feature of animal behaviour, yet many of the molecular, genetic, and neuronal substrates that orchestrate sleep/wake transitions lie undiscovered. Employing a viral insertion sleep screen in larval zebrafish, we identified
Externí odkaz:
https://doaj.org/article/221b77ce3f6641329cfae8555a7e436b