Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome.

Autor: Catron MA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Howe RK; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Besing GK; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., St John EK; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Potesta CV; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gallagher MJ; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Macdonald RL; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zhou C; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publikováno v: Brain communications [Brain Commun] 2022 Dec 17; Vol. 5 (1), pp. fcac332. Date of Electronic Publication: 2022 Dec 17 (Print Publication: 2023).

Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome

Autor: Mackenzie A Catron, Rachel K Howe, Gai-Linn K Besing, Emily K St. John, Cobie Victoria Potesta, Martin J Gallagher, Robert L Macdonald, Chengwen Zhou

Sleep is the preferential period when epileptic spike–wave discharges appear in human epileptic patients, including genetic epileptic seizures such as Dravet syndrome with multiple mutations including SCN1A mutation and GABAA receptor γ2 subunit G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f4398d1b6cd4558f8a2141c4fae69
https://doi.org/10.1101/2022.01.04.474940

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Genetic Epilepsy Model Derived from Common Inbred Mouse Strains

Autor: B A Taylor, Jeffrey L. Noebels, Wayne N. Frankel, Cathleen M. Lutz

Publikováno v: Scopus-Elsevier

The recombinant inbred mouse strain, SWXL-4, exhibits tonic-clonic and generalized seizures similar to the commonest epilepsies in humans. In SWXL-4 animals, seizures are observed following routine handling at about 80 days of age and may be induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d501f154fb7f50d50a588a6e60ca1e
https://europepmc.org/articles/PMC1206164/

Slow Down and Seize: Seizures Triggered by Slow Wave Oscillations in a GABAergic Model of Dravet Syndrome.

Autor: Buchanan, Gordon F.¹ (AUTHOR)

Publikováno v: Epilepsy Currents. Jul2023, Vol. 23 Issue 4, p254-256. 3p.