Zobrazeno 1 - 10
of 772
pro vyhledávání: '"gene set analysis"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4701-4720 (2024)
A crucial feature of life is its spatial organization and compartmentalization on the molecular, cellular, and tissue levels. Spatial transcriptomics (ST) technology has opened a new chapter of the sequencing revolution, emerging rapidly with transfo
Externí odkaz:
https://doaj.org/article/f4011c4a8d2147009cf72ea1ec5811cf
Autor:
Zhipeng Cao, Guilai Zhan, Jinmei Qin, Renata B. Cupertino, Jonatan Ottino-Gonzalez, Alistair Murphy, Devarshi Pancholi, Sage Hahn, Dekang Yuan, Peter Callas, Scott Mackey, Hugh Garavan
Publikováno v:
NeuroImage, Vol 293, Iss , Pp 120622- (2024)
Correlating transcriptional profiles with imaging-derived phenotypes has the potential to reveal possible molecular architectures associated with cognitive functions, brain development and disorders. Competitive null models built by resampling genes
Externí odkaz:
https://doaj.org/article/5bf238024c144747b095adb721d50a2a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Gene-wise differential expression is usually the first major step in the statistical analysis of high-throughput data obtained from techniques such as microarrays or RNA-sequencing. The analysis at gene level is often complemented
Externí odkaz:
https://doaj.org/article/37b072e29845485687c643fd42147c6f
Autor:
Tianyu Deng, Keanning Li, Lili Du, Mang Liang, Li Qian, Qingqing Xue, Shiyuan Qiu, Lingyang Xu, Lupei Zhang, Xue Gao, Xianyong Lan, Junya Li, Huijiang Gao
Publikováno v:
Animals, Vol 14, Iss 11, p 1695 (2024)
Complex traits are widely considered to be the result of a compound regulation of genes, environmental factors, and genotype-by-environment interaction (G × E). The inclusion of G × E in genome-wide association analyses is essential to understand a
Externí odkaz:
https://doaj.org/article/e1253c5ef77f45fdb9df57ff62c542a7
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundSepsis is a dysfunctional host response to infection. The syndrome leads to millions of deaths annually (19.7% of all deaths in 2017) and is the cause of most deaths from severe Covid infections. High throughput sequencing or ‘omics’ ex
Externí odkaz:
https://doaj.org/article/f08ced65fdcb4eb79b0d066964ca14f0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: The impact of gene-sets on a spatial phenotype is not necessarily uniform across different locations of cancer tissue. This study introduces a computational platform, GWLCT, for combining gene set analysis with spatial data modeling to pr
Externí odkaz:
https://doaj.org/article/91a4459eb6f34668a0ab3d20d9f6e82f
Autor:
Foo Wei Ten, Dongsheng Yuan, Nabil Jabareen, Yin Jun Phua, Roland Eils, Sören Lukassen, Christian Conrad
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Feature identification and manual inspection is currently still an integral part of biological data analysis in single-cell sequencing. Features such as expressed genes and open chromatin status are selectively studied in specific contexts, cell stat
Externí odkaz:
https://doaj.org/article/b02bbcd6ab174203b37dc2701d23b875
Autor:
Ayyüce Begüm Bektaş, Mehmet Gönen
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Identification of molecular mechanisms that determine tumour progression in cancer patients is a prerequisite for developing new disease treatment guidelines. Even though the predictive performance of current machine learning mode
Externí odkaz:
https://doaj.org/article/3bdf0d9723b14774a875cc2b5b3bfcca
Autor:
Xiaowei Huang, Xuanyi Lu, Chengshu Xie, Shaurya Jauhari, Zihong Xie, Songqing Mei, Antonio Mora
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Gene Set Analysis (GSA) is one of the most commonly used strategies to analyze omics data. Hundreds of GSA-related papers have been published, giving birth to a GSA field in Bioinformatics studies. However, as the field grows, it is becoming more dif
Externí odkaz:
https://doaj.org/article/2d61b7902e99469dabd088155895c0cb