Zobrazeno 1 - 10
of 2 251
pro vyhledávání: '"gene fusions"'
Autor:
E. A. Khaova, A. G. Tkachenko
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 28, Iss 1, Pp 24-32 (2024)
Polyamines and indole are small regulatory molecules that are involved in the adaptation to stress in bacteria, including the regulation of gene expression. Genes, the translation of which is under the regulatory effects of polyamines, form the polya
Externí odkaz:
https://doaj.org/article/0c097761d526434cb7eb47c57e7c1f3f
Autor:
Wei Zhang, Arndt A. Schmitz, Roosa E. Kallionpää, Merja Perälä, Niina Pitkänen, Mikko Tukiainen, Erika Alanne, Korinna Jöhrens, Renate Schulze-Rath, Bahman Farahmand, Jihong Zong
Publikováno v:
Acta Oncologica, Vol 63, Iss 1 (2024)
Background: Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are oncogenic drivers. Using the Auria Biobank in Finland, we aimed to identify and characterize patients with these gene fusions, and describe their clinical and tumor characteris
Externí odkaz:
https://doaj.org/article/e095f9124f444d38a0377cda8832f56f
Autor:
David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Manuel González-Del Carmen, Alma D. Campos-Parra
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The diagnosis of thyroid cancer (TC) has increased dramatically in recent years. Papillary TC is the most frequent type and has shown a good prognosis. Conventional treatments for TC are surgery, hormonal therapy, radioactive iodine, chemotherapy, an
Externí odkaz:
https://doaj.org/article/be5a42e505a44fd28acebab5c848b8c7
Autor:
David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, Rebeca García-Román, Alma D. Campos-Parra
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101136- (2024)
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mecha
Externí odkaz:
https://doaj.org/article/7addc0437a1045fc90dccb3ee13eb4e8
Autor:
Valeriy V. Breder, Liudmila G. Zhukova, Larisa V. Bolotina, Irina A. Demidova, Yaroslav A. Zhulikov, Elena V. Lubennikova, David R. Naskhletashvili, Sergey V. Orlov, Rashida V. Orlova, Ilya S. Romanov, Nikita A. Savelov, Ksenia A. Sarantseva, Alexandra S. Tyulyandina, Mikhail Yu. Fedyanin
Publikováno v:
Современная онкология, Vol 25, Iss 3, Pp 295-300 (2023)
NTRK-fusion positive tumors are a rare finding, but targeted therapy demonstrates persistent and sustained systemic and intracranial responses to entrectinib. This resolution proposes algorithms for diagnosing NTRK translocations in various solid tum
Externí odkaz:
https://doaj.org/article/c5b921b0ebf8481e8510cf935262712f
Autor:
Richard Armos, Bence Bojtor, Janos Podani, Ildiko Illyes, Bernadett Balla, Zsuzsanna Putz, Andras Kiss, Andrea Kohanka, Erika Toth, Istvan Takacs, Janos P. Kosa, Peter Lakatos
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10787 (2024)
Thyroid cancer is the most common type of endocrine malignancy. Papillary thyroid carcinoma (PTC) is its predominant subtype, which is responsible for the vast majority of cases. It is true that PTC is a malignant tumor with a very good prognosis due
Externí odkaz:
https://doaj.org/article/becef0ab48b647a1b3be03ba3e900413
Autor:
Ana Giménez‐Capitán, Estela Sánchez‐Herrero, Lucía Robado de Lope, Andrés Aguilar‐Hernández, Ivana Sullivan, Virginia Calvo, Irene Moya‐Horno, Santiago Viteri, Carlos Cabrera, Cristina Aguado, Noelia Armiger, Joselyn Valarezo, Clara Mayo‐de‐las‐Casas, Noemí Reguart, Rafael Rosell, Mariano Provencio, Atocha Romero, Miguel A. Molina‐Vila
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1884-1897 (2023)
ALK, ROS1, and RET fusions and MET∆ex14 variant associate with response to targeted therapies in non‐small‐cell lung cancer (NSCLC). Technologies for fusion testing in tissue must be adapted to liquid biopsies, which are often the only material
Externí odkaz:
https://doaj.org/article/895f32ea609d4f95922800c025292cd9
Autor:
Rosa María González-Arreola, Adriana García-Romero, María Teresa Magaña-Torres, Juan Ramón González-García
Publikováno v:
Molecular Cytogenetics, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract Background High expression of the Cytokine Receptor-Like Factor 2 (CRLF2) gene has been observed in patients with acute lymphoblastic leukemia BCR-ABL1-like subtype. Currently, there is no commercial system available for the direct detection
Externí odkaz:
https://doaj.org/article/62bd1fd8f1a647d493707e66cf64b031
Autor:
Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugène T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection. Recent developments
Externí odkaz:
https://doaj.org/article/046a29bb1ff74c6daf6fc9a89b986d88
Autor:
Selene Cipri, Francesco Fabozzi, Giada Del Baldo, Giuseppe Maria Milano, Luigi Boccuto, Andrea Carai, Angela Mastronuzzi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The family of the neurotrophic tyrosine kinase receptor (NTRK) gene encodes for members of the tropomyosin receptor kinase (TRK) family. Rearrangements involving NTRK1/2/3 are rare oncogenic factors reported with variable frequencies in an extensive
Externí odkaz:
https://doaj.org/article/cf10beb382ba46aeafc72aef2a0d4839