Zobrazeno 1 - 10
of 1 640
pro vyhledávání: '"gene expression signature"'
Publikováno v:
Onco, Vol 4, Iss 3, Pp 143-162 (2024)
As precision medicine such as targeted therapy and immunotherapy often have limited accessibility, low response rate, and evolved resistance, it is urgent to develop simple, low-cost, and quick-turnaround personalized diagnostic technologies for drug
Externí odkaz:
https://doaj.org/article/2de7fac8377548099f7b8e31f963a18b
Autor:
Alexandra R. Harris, Tengteng Wang, Yujing J. Heng, Gabrielle M. Baker, Phuong Anh Le, Jun Wang, Christine Ambrosone, Adam Brufsky, Fergus J. Couch, Francesmary Modugno, Christopher G. Scott, Celine M. Vachon, Susan E. Hankinson, Bernard A. Rosner, Rulla M. Tamimi, Cheng Peng, A. Heather Eliassen
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. Methods We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tu
Externí odkaz:
https://doaj.org/article/76b5bacfbc8949afa92769f09a2daa34
Autor:
Daniele Generali, Andrea Rocca, Carla Strina, Manuela Milani, Enrico Fiorino, Valeria Cervoni, Carlo Azzini, Antonella Saracino, Ingnazio Ciliberto, Nicoletta Ziglioli, Marzia Alberio, Fabiola Giudici, Martina Dester, Oriana Ciani, Giulia Fornaro, Sergio Aguggini, Christa Dreezen, Darina Pronin, Stefanie Ende
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39485- (2024)
Purpose: The aim of this study was to assess the prognostic performance of the 70-gene signature, MammaPrint, in an Italian single-center prospective cohort of early-stage intermediate-risk breast cancer (BC) patients. Methods: A total of 195 eligibl
Externí odkaz:
https://doaj.org/article/2786ca856aa34c789634138ba4c8b901
Autor:
Mahmood Rasool, Sajjad Karim, Absarul Haque, Mohammed Alharthi, Adeel G Chaudhary, Peter Natesan Pushparaj
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 9, Pp 103415- (2024)
Background: Colorectal cancer (CRC) liver metastasis (CRLM) is a clinical challenge, and optimizing treatment strategies is crucial for improving patient outcomes. This study aimed to identify gene expression signatures associated with CRLM for early
Externí odkaz:
https://doaj.org/article/22de55fa872c4767a0178760a12c01b2
Autor:
Chengfei Jiang, Lingyan Chen, Chunping Ye, Suzaynn F. Schick, Peyton Jacob, III, Yingjia Zhuang, Jamie L. Inman, Changbin Chen, Lara A. Gundel, Hang Chang, Antoine M. Snijders, Xiaoping Zou, Jian-Hua Mao, Bo Hang, Pin Wang
Publikováno v:
Environment International, Vol 191, Iss , Pp 108986- (2024)
The pollution of indoor environments and the consequent health risks associated with thirdhand smoke (THS) are increasingly recognized in recent years. However, the carcinogenic potential of THS and its underlying mechanisms have yet to be thoroughly
Externí odkaz:
https://doaj.org/article/ccd07ac39d6646848a042f38c1bb2a4a
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Although substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately stratify the patients is still limited. In this study, we aim to leverage large-scale radiogenom
Externí odkaz:
https://doaj.org/article/7784e6f2a2db4c85bac99cf3f2fde13b
Autor:
Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Lorens, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Steinar Daae Johansen, Ole-Morten Seternes, Maria Perander
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium
Externí odkaz:
https://doaj.org/article/0cb38a8096c34f07953bff36029fd95d
EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas
Autor:
Alice Turdo, Miriam Gaggianesi, Caterina D’Accardo, Gaetana Porcelli, Sebastiano Di Bella, Dario Cricchio, Irene Pillitteri, Rossana Porcasi, Melania Lo Iacono, Francesco Verona, Chiara Modica, Narges Roozafzay, Ada Maria Florena, Giorgio Stassi, Salvatrice Mancuso, Matilde Todaro
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDiffuse large B-cell lymphoma (DLBCL) is a hematological malignancy representing one-third of non-Hodgkin’s lymphoma cases. Notwithstanding immunotherapy in combination with chemotherapy (R-CHOP) is an effective therapeutic approach for D
Externí odkaz:
https://doaj.org/article/b198c3f32aad41e698a82358a2a2963c
Autor:
Jieqi Jin, Mengkai Guang, Simin Li, Yong Liu, Liwei Zhang, Bo Zhang, Menglin Cheng, Gerhard Schmalz, Xiaofeng Huang
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Periodontits (PD) and Alzheimer’s disease (AD) are both associated with ageing and clinical studies increasingly evidence their association. However, specific mechanisms underlying this association remain undeciphered, and immune-relate
Externí odkaz:
https://doaj.org/article/f41ac23b55ff4f9fa9a7552e6ee7fb65
Autor:
Sarah Asad, Adrienne Damicis, Yujing J. Heng, Kathryn Kananen, Katharine A. Collier, Elizabeth J. Adams, Kevin H. Kensler, Gabrielle M. Baker, Robert Wesolowski, Sagar Sardesai, Margaret Gatti-Mays, Bhuvaneswari Ramaswamy, A. Heather Eliassen, Susan E. Hankinson, Fred K. Tabung, Rulla M. Tamimi, Daniel G. Stover
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Background Breast tumor immune infiltration is clearly associated with improved treatment response and outcomes in breast cancer. However, modifiable patient factors associated with breast cancer immune infiltrates are poorly understood. The
Externí odkaz:
https://doaj.org/article/bfd391b7b4c543cc8e9f6b20a3f6dcf9