Zobrazeno 1 - 10
of 146
pro vyhledávání: '"gene and cell therapy"'
Publikováno v:
Ведомости Научного центра экспертизы средств медицинского применения, Vol 14, Iss 1, Pp 29-41 (2024)
SCIENTIFIC RELEVANCE. Currently, the Russian Federation lacks a comprehensive regulatory framework for the use of gene and cell therapy (GCT) products. There is no standard for conducting clinical trials for purposes other than marketing authorisatio
Externí odkaz:
https://doaj.org/article/e4c8c599afe444d8af64fbd6bb57c473
Autor:
Alla Zorina, Vadim Zorin, Artur Isaev, Dmitry Kudlay, Natalia Manturova, Andrei Ustugov, Pavel Kopnin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10270 (2024)
This detailed review describes innovative strategies and current products for gene and cell therapy at different stages of research and development to treat recessive dystrophic epidermolysis bullosa (RDEB) which is associated with the functional def
Externí odkaz:
https://doaj.org/article/49ca6b2d23fb4ddc827171237526e659
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 582-592 (2021)
Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduce
Externí odkaz:
https://doaj.org/article/8d9f5440d6cd42d0a5f0940f9f1a0fa1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Yasuhiro Kazuki, Narumi Uno, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Yuwna Yakura, Chiaki Sawada, Shuta Takata, Masaki Sugawara, Yuichi Nagashima, Akane Okada, Masaharu Hiratsuka, Mitsuhiko Osaki, Giulia Ferrari, Francesco Saverio Tedesco, Satoshi Nishikawa, Ken Fukumoto, Shin-ichiro Takayanagi, Atsushi Kunisato, Shin Kaneko, Mitsuo Oshimura, Kazuma Tomizuka
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 629-639 (2021)
Genetic engineering of induced pluripotent stem cells (iPSCs) holds great promise for gene and cell therapy as well as drug discovery. However, there are potential concerns regarding the safety and control of gene expression using conventional vector
Externí odkaz:
https://doaj.org/article/4ad8e0395e06453281ae9cc22fa1587b
Autor:
Matthew Bauler, Jessica K. Roberts, Chang-Chih Wu, Baochang Fan, Francesca Ferrara, Bon Ham Yip, Shiyong Diao, Young-In Kim, Jennifer Moore, Sheng Zhou, Matthew M. Wielgosz, Byoung Ryu, Robert E. Throm
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 58-68 (2020)
Lentiviral vectors are increasingly utilized in cell and gene therapy applications because they efficiently transduce target cells such as hematopoietic stem cells and T cells. Large-scale production of current Good Manufacturing Practices-grade lent
Externí odkaz:
https://doaj.org/article/98f0f57ad9d84a559004adf29ea87cd2
Autor:
Kyan James Allahdadi, Thaís Alves de Santana, Girlaine Café Santos, Carine Machado Azevedo, Roberta Alves Mota, Carolina Kymie Nonaka, Daniela Nascimento Silva, Clarissa Xavier Resende Valim, Cláudio Pereira Figueira, Washington Luis Conrado dos Santos, Renan Fernandes do Espirito Santo, Afrânio Ferreira Evangelista, Cristiane Flora Villarreal, Ricardo Ribeiro dos Santos, Bruno Solano Freitas de Souza, Milena Botelho Pereira Soares
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated whether BMMSCs overexpress
Externí odkaz:
https://doaj.org/article/3c1212cb1aaa49e8883602bc68babc8b
Publikováno v:
Frontiers in Medicine. 10
Publikováno v:
Mol Ther Oncolytics
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 582-592 (2021)
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 582-592 (2021)
Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduce
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1602 (2020)
Retinal development is under the coordinated control of overlapping networks of signaling pathways and transcription factors. The paper was conceived as a review of the data and ideas that have been formed to date on homeobox genes mutations that lea
Externí odkaz:
https://doaj.org/article/aff6bfb8221943139d5631a29f0ae759