Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy

Autor: Zhengyao Cai, Suxin Yuan, Xingzhao Luan, Jian Feng, Li Deng, Yumei Zuo, Jiafu Li

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Pyroptosis is a highly specific type of inflammatory programmed cell death that is mediated by Gasdermine (GSDM). It is characterized by inflammasome activation, caspase activation, and cell membrane pore formation. Diabetic cardiomyopathy (DCM) is o

Externí odkaz: https://doaj.org/article/4294d47af5b243d7b636faee0a483014

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis.

Autor: Xiao J; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sun K; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Wang C; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Abu-Amer Y; Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.; Shriners Hospital for Children, St. Louis, Missouri, USA., Mbalaviele G; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2022 Aug 30; Vol. 5, pp. 100162. Date of Electronic Publication: 2022 Aug 30 (Print Publication: 2022).