Zobrazeno 1 - 10
of 241
pro vyhledávání: '"gasdermin e"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract The Gasdermin E gene (GSDME) plays roles in deafness and cancers. However, the roles and mechanisms in cancers are complex, and the same gene exhibits different mechanisms and actions in different types of cancers. Online databases, such as
Externí odkaz:
https://doaj.org/article/f98d018f76594807a8d9411c00548cfe
Autor:
Huan LI, Xudong TANG
Publikováno v:
Chinese Journal of Lung Cancer, Vol 27, Iss 7, Pp 529-534 (2024)
Lung cancer causes a significant threat to human health. Despite considerable advancements in the treatment technologies in recent years, the five-year survival rate for lung cancer patients remains low. In this context, the discovery of pyroptosis,
Externí odkaz:
https://doaj.org/article/291a216b12844786a2481a307364cd39
Autor:
Juanmei Cao, Yong Qu, Shaojie Zhu, Jinshan Zhan, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Chuxing Chai, Xiangwei Wu, Meng Gao, Changzheng Huang, Min Li
Publikováno v:
Aggregate, Vol 5, Iss 6, Pp n/a-n/a (2024)
Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal tumors, in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because
Externí odkaz:
https://doaj.org/article/f4f25c6b19f34caf850bd652ca42fe4b
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and whether it could benefi
Externí odkaz:
https://doaj.org/article/088e64b85cdd483d9d6ec043a6d24ab7
Autor:
Ke Jiang, Qi He, Chenhui Wang, Wen Yang, Changdong Zhou, Jian Li, Jiangbo Li, Yuke Cui, Jingqi Shi, Zhenqiao Wei, Yuanyuan Jiao, Ligai Bai, Shengqi Wang, Liang Guo
Publikováno v:
Biomedicines, Vol 12, Iss 11, p 2526 (2024)
Background: The continuous clinical use of cisplatin is prevented by gastrointestinal toxicity. Methods: Cisplatin was used to treat THP-1-derived macrophages to see its differential effects on different subtypes of macrophages. Wild-type and Gsdme
Externí odkaz:
https://doaj.org/article/be0a57a9ed8644e2a293fa752cee4dc4
Autor:
Rohail Bhatti, Priscila Y. Sato
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Cell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed. Unbalanced cell death can lead to uncontrolled cell proliferation (i.e., tumors) or exc
Externí odkaz:
https://doaj.org/article/db1061e5a40c45dd86a612d6d0c78c8b
Autor:
Yang Liu, Xiaowei Zhang, Ping Zhang, Tingting He, Weitao Zhang, Dingyuan Ma, Ping Li, Jun Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 4253-4272 (2023)
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells
Externí odkaz:
https://doaj.org/article/577d5a181eba45ffa92a5add7df625b0
Autor:
Wenchang Yang, Yaxin Wang, Tao Wang, Chengguo Li, Liang Shi, Peng Zhang, Yuping Yin, Kaixiong Tao, Ruidong Li
Publikováno v:
Genes and Diseases, Vol 10, Iss 4, Pp 1552-1563 (2023)
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catal
Externí odkaz:
https://doaj.org/article/c5932bb50d16407fbda024c53adbcd2f
Publikováno v:
eLife, Vol 12 (2024)
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, human GSDME is
Externí odkaz:
https://doaj.org/article/662be3aceaff424486d20c1c98611d32
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.