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Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

Autor: Arthur Laganowsky, Kaare Teilum, Mikael Oliveberg, Justin L. P. Benesch, Rui M. M. Branca, Erik G. Marklund, Joana Costeira-Paulo, Mia L Abramsson, Mingming Xu, Lisa Lang, Michael Landreh, Leopold L. Ilag, Carol V. Robinson, Axel Leppert, Jonathan T. S. Hopper, Shane A. Chandler, Timothy M. Allison, Nicklas Österlund, Cagla Sahin, Jens Danielsson, Jakob R. Winther

Publikováno v: JACS Au
Abramsson, M L, Sahin, C, Hopper, J T S, Branca, R M M, Danielsson, J, Xu, M, Chandler, S A, Österlund, N, Ilag, L L, Leppert, A, Costeira-Paulo, J, Lang, L, Teilum, K, Laganowsky, A, Benesch, J L P, Oliveberg, M, Robinson, C V, Marklund, E G, Allison, T M, Winther, J R & Landreh, M 2021, ' Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry ', JACS Au, vol. 1, no. 12, pp. 2385-2393 . https://doi.org/10.1021/jacsau.1c00458
JACS Au, Vol 1, Iss 12, Pp 2385-2393 (2021)

In solution, the charge of a protein is intricately linked to its stability, but electrospray ionization distorts this connection, potentially limiting the ability of native mass spectrometry to inform about protein structure and dynamics. How the be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5e9d258ed55683ae9250b0d910a94b

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Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

Autor: Jean-Yves Salpin, Barbara Chiavarino, Debora Scuderi, Maria Elisa Crestoni, Simonetta Fornarini

Publikováno v: Inorganic Chemistry
Inorganic Chemistry, 2017, 56 (15), pp.8793-8801. ⟨10.1021/acs.inorgchem.7b00570⟩
Inorganic Chemistry, American Chemical Society, 2017, 56 (15), pp.8793-8801. ⟨10.1021/acs.inorgchem.7b00570⟩

International audience; The complex obtained by the reaction of cisplatin and 2′-deoxyadenosine-5′-monophosphate (5′-dAMP) in water has been isolated and detected by electrospray ionization mass spectrometry. The so-formed cis-[PtCl(NH3)2(5′-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa2387aba66d7b06ae5309d5e133849
https://doi.org/10.1021/acs.inorgchem.7b00570