Zobrazeno 1 - 10
of 264
pro vyhledávání: '"ganglioside binding"'
Autor:
Beata Bugara, Małgorzata Durbas, Maja Kudrycka, Agata Malinowska, Irena Horwacik, Hanna Rokita
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor originating from the abnormal development of cells of the sympathoadrenal lineage of the neural crest. Targeting GD2 ganglioside (GD2), a glycolipid expressed on neuroblastoma c
Externí odkaz:
https://doaj.org/article/4f50ebe42f5d426ead4004b9221299a9
Publikováno v:
FEBS Open Bio, Vol 10, Iss 3, Pp 298-305 (2020)
Botulinum neurotoxins (BoNTs) are one of the most toxic proteins known to humans. Their molecular structure is comprised of three essential domains—a cell binding domain (HC), translocation domain and catalytic domain (light chain) . The HC domain
Externí odkaz:
https://doaj.org/article/1cdef2f317864057b51401ece16369a1
Autor:
Kyle S. Gregory, K. Ravi Acharya
Publikováno v:
Toxins, Vol 15, Iss 2, p 92 (2023)
Botulinum neurotoxins (BoNTs) cause flaccid neuromuscular paralysis by cleaving one of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex proteins. BoNTs display high affinity and specificity for neuromuscular j
Externí odkaz:
https://doaj.org/article/15e3ead70a664f048026b993ca13320f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Besides amyloid fibrils, amyloid pores (APs) represent another mechanism of amyloid induced toxicity. Since hypothesis put forward by Arispe and collegues in 1993 that amyloid-beta makes ion-conducting channels and that Alzheimer's disease may be due
Externí odkaz:
https://doaj.org/article/503d9970a8db4682825636f85eb5c465
Publikováno v:
Toxins, Vol 14, Iss 5, p 356 (2022)
Botulinum neurotoxins (BoNT) are a group of clostridial toxins that cause the potentially fatal neuroparalytic disease botulism. Although highly toxic, BoNTs are utilized as therapeutics to treat a range of neuromuscular conditions. Several serotypes
Externí odkaz:
https://doaj.org/article/74136a3a6d9442c288f712c255acd27b
Publikováno v:
Toxins, Vol 14, Iss 2, p 129 (2022)
Botulinum neurotoxins (BoNT) cause the potentially fatal neuroparalytic disease botulism that arises due to proteolysis of a SNARE protein. Each BoNT is comprised of three domains: a cell binding domain (HC), a translocation domain (HN), and a cataly
Externí odkaz:
https://doaj.org/article/9669e8f625fc40b3a6061f10f9e9c634
Akademický článek
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Autor:
Ron S. Broide, Birgitte S. Jacky, Amy Brideau-Andersen, Catherine Rheaume, David M. Jameson, Nicholas G. James, Bethany J. Sanstrum, Shiazah Z. Malik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d4a9eb2a4748f04d9486588f007e80
https://doaj.org/article/b42c13adfc0c41cca508116cf7c6999f
https://doaj.org/article/b42c13adfc0c41cca508116cf7c6999f
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 10, Iss 3, Pp 298-305 (2020)
FEBS Open Bio, Vol 10, Iss 3, Pp 298-305 (2020)
Botulinum neurotoxins (BoNTs) are one of the most toxic proteins known to humans. Their molecular structure is comprised of three essential domains—a cell binding domain (HC), translocation domain and catalytic domain (light chain) . The HC domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cc402b96998c7bbc0608ec0135316f
http://europepmc.org/articles/PMC7050238
http://europepmc.org/articles/PMC7050238
Autor:
P. M. Mitrasinovic
Publikováno v:
Revue Roumaine de Chimie. 65:1099-1109
The infectious disease CoViD-19 is caused by a new severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). A possible infection mechanism includes dual host receptor recognitions by the SARS-CoV-2 transmembrane spike (S) glycoproteins. SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64cb3c91ad1bce2e1ae8622c8b3e3fc0
https://doi.org/10.33224/rrch.2020.65.12.05
https://doi.org/10.33224/rrch.2020.65.12.05