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Akademický článek

DNA damage and arterial hypertension. A systematic review and meta-analysis

Autor: Radka Hazukova, Martina Rezacova, Miloslav Pleskot, Zdenek Zadak, Eva Cermakova, Milos Taborsky

Publikováno v: Biomedical Papers, Vol 168, Iss 1, Pp 15-24 (2024)

Oxidative DNA damage markers (8OHdG, comet assay, gammaH2AX) are becoming widely used in clinical cardiology research. To conduct this review of DNA damage in relation to hypertension in humans, we used databases (e.g. PubMed, Web of Science) to sear

Externí odkaz: https://doaj.org/article/133181a842bf4c1791efdd54c58ee0f3

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Akademický článek

Bystander Response Following High-Dose X-irradiation; Time-dependent Nature of GammaH2AX Foci and Cell Death Consequences

Autor: Fatemeh Pakniyat, Hossein Mozdarani, Hassan Ali Nedaee, Aziz Mahmoudzadeh, Mahdieh Salimi, Somayeh Gholami

Publikováno v: Journal of Biomedical Physics and Engineering, Vol 13, Iss 1, Pp 17-28 (2023)

Background: The paradigm shifts in target theory could be defined as the radiation-triggered bystander response in which the radiation deleterious effects occurred in the adjacent cells. Objective: This study aims to assess bystander response in term

Externí odkaz: https://doaj.org/article/7321b81d06fd4bd38f35525f5be1c818

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Akademický článek

Evaluation of Capability and Relationship of Different Radiobiological Endpoints for Radiosensitivity Prediction in Human Tumor Cell Lines Compared with Clonogenic Survival

Autor: Fatemeh Pakniyat, Hassan Ali Nedaee, Hossein Mozdarani, Aziz Mahmoudzadeh, Somayeh Gholami

Publikováno v: Journal of Biomedical Physics and Engineering, Vol 12, Iss 2, Pp 127-136 (2022)

Background: Establishing a predictive assay of radiosensitivity (as an appropriate, practical and cost-effective method) has been challenging. Objective: The purpose of this study is to evaluate the capability and relationship of various endpoints, i

Externí odkaz: https://doaj.org/article/b34887754ebf4df585bf9e4ac68481b7

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Akademický článek

Effect of Paternal DNA Damage on Paternal DNA Degradation and Early Embryonic Development in Mouse Embryo: Supporting Evidence by GammaH2AX Expression

Autor: Chang Jin Kim, Kyung-Bon Lee

Publikováno v: Journal of Animal Reproduction and Biotechnology, Vol 34, Iss 3, Pp 197-204 (2019)

This study was investigated to test whether the zygote recognized the topoisomerase II beta (TOP2B) mediated DNA fragmentation in epididymal spermatozoa or the nuclease degradation in vas deferens spermatozoa by testing for the presence of gammaH2AX

Externí odkaz: https://doaj.org/article/fd151306be1f46808bf1e442ae68713d

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Akademický článek

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Akademický článek

Biological indicators of chemoresistance: an ex vivo analysis of γH2AX and p53 expression in feline injection-site sarcomas

Autor: Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard, Kelly R. Hume

Publikováno v: Cancer Cell International, Vol 18, Iss 1, Pp 1-13 (2018)

Abstract Background The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that many chemotherapeutic

Externí odkaz: https://doaj.org/article/018ff573f97146c0840fc2c6a44c5850

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Akademický článek

Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

Autor: Natalia Soledad Paviolo, María Belén de la Vega, María Florencia Pansa, Iris Alejandra García, Nicolás Luis Calzetta, Gastón Soria, Vanesa Gottifredi

Publikováno v: Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2019)

Abstract The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand b

Externí odkaz: https://doaj.org/article/afb09438748741158b7b51590b60777d

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Evaluating the Suitability of 3D Bioprinted Samples for Experimental Radiotherapy: A Pilot Study

Autor: Schültke, Munir A. Al-Zeer, Franziska Prehn, Stefan Fiedler, Ulrich Lienert, Michael Krisch, Johanna Berg, Jens Kurreck, Guido Hildebrandt, Elisabeth

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9951

Radiotherapy is an important component in the treatment of lung cancer, one of the most common cancers worldwide, frequently resulting in death within only a few years of diagnosis. In order to evaluate new therapeutic approaches and compare their ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::bf93632b6018dd563c77244210005039

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