Zobrazeno 1 - 10
of 2 509
pro vyhledávání: '"gamma- delta T cells"'
Autor:
Somen K Mistri, Brianna M Hilton, Katherine J Horrigan, Emma S Andretta, Remi Savard, Oliver Dienz, Kenneth J Hampel, Diana L Gerrard, Joshua T Rose, Nikoletta Sidiropoulos, Dev Majumdar, Jonathan E Boyson
Publikováno v:
eLife, Vol 13 (2024)
During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental progr
Externí odkaz:
https://doaj.org/article/0c074fa78fa34bb4a64e74d5eb6fbdbd
Autor:
Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells. Until now, their role in MDV pathogenesis and tumor for
Externí odkaz:
https://doaj.org/article/0c96e4576b904e06a16d362eecd77b83
Publikováno v:
Cancer Reports, Vol 7, Iss 5, Pp n/a-n/a (2024)
Abstract Background The tumor microenvironment of solid tumors governs the differentiation of otherwise non‐immunosuppressive macrophages and gamma delta (γδ) T cells into strong immunosuppressors while promoting suppressive abilities of known im
Externí odkaz:
https://doaj.org/article/e774c690f04f4d0c9f46cb47e852123a
Autor:
Kiran K. Parwani, Gianna M. Branella, Rebecca E. Burnham, Andre J. Burnham, Austre Y. Schiaffino Bustamante, Elisabetta Manuela Foppiani, Kristopher A. Knight, Brian G. Petrich, Edwin M. Horwitz, Christopher B. Doering, H. Trent Spencer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing
Externí odkaz:
https://doaj.org/article/f3f5f8f350124206a8b21fc88a9f4d24
Autor:
Scott A. Becker, Brian G. Petrich, Bing Yu, Kristopher A. Knight, Harrison C. Brown, Sunil S. Raikar, Christopher B. Doering, H. Trent Spencer
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 145-157 (2023)
Adoptive cell therapy (ACT) utilizing γδ T cells is becoming a promising option for the treatment of cancer, because it offers an off-the-shelf allogeneic product that is safe, potent, and clinically effective. Approaches to engineer or enhance imm
Externí odkaz:
https://doaj.org/article/53f3291d08774bab9a7136bad26a24d2
Autor:
Sujata Mukherjee, Maria E. C. Bruno, Jason Oakes, Gregory S. Hawk, Arnold J. Stromberg, Donald A. Cohen, Marlene E. Starr
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
γδ T cells are resident in visceral adipose tissue (VAT) where they show an age-associated increase in numbers and contribute to local and systemic chronic inflammation. However, regulation of this population and mechanisms for the age-dependent ac
Externí odkaz:
https://doaj.org/article/21b27b1d33fd4d64af3e474cb9345443
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesothelioma is an aggressive tumor in the pleural cavity that is difficult to treat. Diagnosis is usually late with minimal treatment options available for the patients and with unfavorable outcomes. However, recent advances in immunothe
Externí odkaz:
https://doaj.org/article/dc69b6f6af2948ae9e777d7518a80efa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm birth survivors characterized by inflammation, impaired alveolarization and dysmorphic vasculature. Activated IL-17A+ lymphocytes are key drivers of inflammation in preterm infants
Externí odkaz:
https://doaj.org/article/f43bc4955ae048afb82a11b0a7f217aa
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Akademický článek
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