Zobrazeno 1 - 10
of 2 488
pro vyhledávání: '"gamma delta T cells"'
Autor:
Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells. Until now, their role in MDV pathogenesis and tumor for
Externí odkaz:
https://doaj.org/article/0c96e4576b904e06a16d362eecd77b83
Publikováno v:
Cancer Reports, Vol 7, Iss 5, Pp n/a-n/a (2024)
Abstract Background The tumor microenvironment of solid tumors governs the differentiation of otherwise non‐immunosuppressive macrophages and gamma delta (γδ) T cells into strong immunosuppressors while promoting suppressive abilities of known im
Externí odkaz:
https://doaj.org/article/e774c690f04f4d0c9f46cb47e852123a
Autor:
Scott A. Becker, Brian G. Petrich, Bing Yu, Kristopher A. Knight, Harrison C. Brown, Sunil S. Raikar, Christopher B. Doering, H. Trent Spencer
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 145-157 (2023)
Adoptive cell therapy (ACT) utilizing γδ T cells is becoming a promising option for the treatment of cancer, because it offers an off-the-shelf allogeneic product that is safe, potent, and clinically effective. Approaches to engineer or enhance imm
Externí odkaz:
https://doaj.org/article/53f3291d08774bab9a7136bad26a24d2
Autor:
Kiran K. Parwani, Gianna M. Branella, Rebecca E. Burnham, Andre J. Burnham, Austre Y. Schiaffino Bustamante, Elisabetta Manuela Foppiani, Kristopher A. Knight, Brian G. Petrich, Edwin M. Horwitz, Christopher B. Doering, H. Trent Spencer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing
Externí odkaz:
https://doaj.org/article/f3f5f8f350124206a8b21fc88a9f4d24
Autor:
Sujata Mukherjee, Maria E. C. Bruno, Jason Oakes, Gregory S. Hawk, Arnold J. Stromberg, Donald A. Cohen, Marlene E. Starr
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
γδ T cells are resident in visceral adipose tissue (VAT) where they show an age-associated increase in numbers and contribute to local and systemic chronic inflammation. However, regulation of this population and mechanisms for the age-dependent ac
Externí odkaz:
https://doaj.org/article/21b27b1d33fd4d64af3e474cb9345443
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesothelioma is an aggressive tumor in the pleural cavity that is difficult to treat. Diagnosis is usually late with minimal treatment options available for the patients and with unfavorable outcomes. However, recent advances in immunothe
Externí odkaz:
https://doaj.org/article/dc69b6f6af2948ae9e777d7518a80efa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm birth survivors characterized by inflammation, impaired alveolarization and dysmorphic vasculature. Activated IL-17A+ lymphocytes are key drivers of inflammation in preterm infants
Externí odkaz:
https://doaj.org/article/f43bc4955ae048afb82a11b0a7f217aa
Autor:
Beatriz Martín-Antonio
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/fea7b98d19cb42afb2cceebe75c08407
Autor:
Jian Wan, Qian Zhang, Yilong Hao, Zhang Tao, Wei Song, Song Chen, Long Qin, Weidong Song, Yi Shan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionSepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play a protective role in sepsis. Howeve
Externí odkaz:
https://doaj.org/article/bcdc9a8a66f84eb6950dd1142089f12a
Autor:
Naoya Imahashi, Masashi Satoh, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Kazuya Iwabuchi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and influence the development of immune-mediated diseases. The MHC class Ib molecule MHC-r
Externí odkaz:
https://doaj.org/article/5a184c8dec8544e3993d7af9ff153563