Zobrazeno 1 - 10
of 70
pro vyhledávání: '"gamma delta (γδ) T cells"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
γδ T-cells are a rare population of T-cells with both adaptive and innate-like properties. Despite their low prevalence, they have been found to be implicated various human diseases. γδ T-cell infiltration has been associated with improved clinic
Externí odkaz:
https://doaj.org/article/4d003fdcc7094e72971a427d4acca1ef
Autor:
Thilo Müller, Lina Alasfar, Friederike Preuß, Lisa Zimmermann, Mathias Streitz, Patrick Hundsdörfer, Angelika Eggert, Johannes Schulte, Arend von Stackelberg, Lena Oevermann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Gamma delta (γδ) T cells represent a minor fraction of human T cell repertoire but play an important role in mediating anti-infectious and anti-tumorous effects in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We pe
Externí odkaz:
https://doaj.org/article/3c49e56c15f64739865ff6596b2fb1c1
Autor:
Tamara Verkerk, Anouk T. Pappot, Tineke Jorritsma, Lisa A. King, Mariël C. Duurland, Robbert M. Spaapen, S. Marieke van Ham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
γδ T cells are important components of the immune system due to their ability to elicit a fast and strong response against infected and transformed cells. Because they can specifically and effectively kill target cells in an MHC independent fashion
Externí odkaz:
https://doaj.org/article/8cc2c6afe3914487bb9450fe03637713
Autor:
Kombo F. N’guessan, Kawthar Machmach, Isabella Swafford, Margaret C. Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R. Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A. Ake, Robert J. O’connell, Sandhya Vasan, Dominic Paquin-Proulx
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The RV144 Thai phase III clinical trial’s canarypox–protein HIV vaccine regimen showed modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine administration on innate cell activation and subsequent associat
Externí odkaz:
https://doaj.org/article/b63b37f19fa546188d5104a25d963234
Autor:
Gianna M. Branella, Jasmine Y. Lee, Jennifer Okalova, Kiran K. Parwani, Jordan S. Alexander, Raquel F. Arthuzo, Andrew Fedanov, Bing Yu, David McCarty, Harrison C. Brown, Shanmuganathan Chandrakasan, Brian G. Petrich, Christopher B. Doering, H. Trent Spencer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The application of immunotherapies such as chimeric antigen receptor (CAR) T therapy or bi-specific T cell engager (BiTE) therapy to manage myeloid malignancies has proven more challenging than for B-cell malignancies. This is attributed to a shortag
Externí odkaz:
https://doaj.org/article/075381e09c6f4fada8ebe38297960f22
Autor:
Marta Sanz, Ann Marie K. Weideman, Adam R. Ward, Matthew L. Clohosey, Susana Garcia-Recio, Sara R. Selitsky, Brendan T. Mann, Marie Anne Iannone, Chloe P. Whitworth, Alisha Chitrakar, Carolina Garrido, Jennifer Kirchherr, Alisha R. Coffey, Yi- Hsuan Tsai, Shahryar Samir, Yinyan Xu, Dennis Copertino, Alberto Bosque, Brad R. Jones, Joel S. Parker, Michael G. Hudgens, Nilu Goonetilleke, Natalia Soriano-Sarabia
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts to cure HIV-1 infection include “shock and kill” strategies to disrupt latency using sm
Externí odkaz:
https://doaj.org/article/88374e57932242c08c418283c9d5a0d0
Autor:
Seungyoul Oh, Xin Liu, Sara Tomei, Mengxiao Luo, Jarrod P. Skinner, Stuart P. Berzins, Shalin H. Naik, Daniel H. D. Gray, Mark M. W. Chong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The αβ and γδ T cell lineages both differentiate in the thymus from common uncommitted progenitors. The earliest stage of T cell development is known as CD4-CD8- double negative 1 (DN1), which has previously been shown to be a heterogenous mixtur
Externí odkaz:
https://doaj.org/article/9b72aa6e5c374c97a013a70b3a3adc47
Autor:
Marta Sanz, Brendan T. Mann, Paul L. Ryan, Alberto Bosque, Daniel J. Pennington, Holger Hackstein, Natalia Soriano-Sarabia
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independe
Externí odkaz:
https://doaj.org/article/9fed376318a4488d8eed264cc84fc1bb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/e2387f44ed24463188790ad6ff13d3a5
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a complex disease which immune response can be more or less potent. In severe cases, patients might experience a cytokine storm
Externí odkaz:
https://doaj.org/article/3d43aea077d143598412aef32e868dff